ID   MNHB1_STAES             Reviewed;         142 AA.
AC   Q8CPU9;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Na(+)/H(+) antiporter subunit B1;
DE   AltName: Full=Mnh complex subunit B1;
GN   Name=mnhB1; OrderedLocusNames=SE_0645;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Mnh complex is a Na(+)/H(+) antiporter involved in Na(+)
CC       excretion. {ECO:0000250}.
CC   -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC       subunits: mnhA1, mnhB1, mnhC1, mnhD1, mnhE1, mnhF1 and mnhG1.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit B
CC       family. {ECO:0000305}.
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DR   EMBL; AE015929; AAO04242.1; -; Genomic_DNA.
DR   RefSeq; NP_764200.1; NC_004461.1.
DR   RefSeq; WP_001831999.1; NZ_WBME01000044.1.
DR   AlphaFoldDB; Q8CPU9; -.
DR   SMR; Q8CPU9; -.
DR   STRING; 176280.SE_0645; -.
DR   EnsemblBacteria; AAO04242; AAO04242; SE_0645.
DR   GeneID; 50019208; -.
DR   KEGG; sep:SE_0645; -.
DR   PATRIC; fig|176280.10.peg.618; -.
DR   eggNOG; COG2111; Bacteria.
DR   HOGENOM; CLU_101659_1_1_9; -.
DR   OMA; HPGFLMP; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR005281; CPA3_sub_B.
DR   InterPro; IPR007182; MnhB.
DR   Pfam; PF04039; MnhB; 1.
DR   TIGRFAMs; TIGR00943; 2a6301s02; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Hydrogen ion transport; Ion transport; Membrane;
KW   Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..142
FT                   /note="Na(+)/H(+) antiporter subunit B1"
FT                   /id="PRO_0000372113"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        37..57
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        116..136
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   142 AA;  15790 MW;  3467B43DCFA29EAF CRC64;
     MNRQQNNLIF QYAAVIIFFM VIVFGFSLFL AGHYTPGGGF VGGLLFASAL LVITIAYDVK
     TMRKIFPLDF KILIGIGLLF CVGTPLTSWF MSKNFFTHVT FDIPLPLLEP MHMTTAMFFD
     FGVLCAVVGT IMTIIISIGE NE