ID   MNHC1_STAA3             Reviewed;         113 AA.
AC   Q2FIC5;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 2.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Na(+)/H(+) antiporter subunit C1;
DE   AltName: Full=Mnh complex subunit C1;
GN   Name=mnhC1; OrderedLocusNames=SAUSA300_0853;
OS   Staphylococcus aureus (strain USA300).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=367830;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USA300;
RX   PubMed=16517273; DOI=10.1016/s0140-6736(06)68231-7;
RA   Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA   Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA   Perdreau-Remington F.;
RT   "Complete genome sequence of USA300, an epidemic clone of community-
RT   acquired meticillin-resistant Staphylococcus aureus.";
RL   Lancet 367:731-739(2006).
CC   -!- FUNCTION: Mnh complex is a Na(+)/H(+) antiporter involved in Na(+)
CC       excretion. {ECO:0000250}.
CC   -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC       subunits: mnhA1, mnhB1, mnhC1, mnhD1, mnhE1, mnhF1 and mnhG1.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit C
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABD21648.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000255; ABD21648.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_000402803.1; NZ_CP027476.1.
DR   AlphaFoldDB; Q2FIC5; -.
DR   SMR; Q2FIC5; -.
DR   EnsemblBacteria; ABD21648; ABD21648; SAUSA300_0853.
DR   GeneID; 66839148; -.
DR   KEGG; saa:SAUSA300_0853; -.
DR   HOGENOM; CLU_082058_3_1_9; -.
DR   Proteomes; UP000001939; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR006673; Mnh_C1_su.
DR   InterPro; IPR039428; NUOK/Mnh_C1-like.
DR   Pfam; PF00420; Oxidored_q2; 1.
DR   TIGRFAMs; TIGR00941; 2a6301s03; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Hydrogen ion transport; Ion transport; Membrane;
KW   Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..113
FT                   /note="Na(+)/H(+) antiporter subunit C1"
FT                   /id="PRO_0000372124"
FT   TRANSMEM        6..26
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   113 AA;  12293 MW;  094DCCA526E23835 CRC64;
     MEIIMIFVSG ILTAISVYLV LSKSLIRIVM GTTLLTHAAN LFLITMGGLK HGTVPIYEAN
     VKSYVDPIPQ ALILTAIVIA FATTAFFLVL AFRTYKELGT DNVESMKGVP EDD