ID   MNHC1_STAAB             Reviewed;         113 AA.
AC   Q2YWT6;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 92.
DE   RecName: Full=Na(+)/H(+) antiporter subunit C1;
DE   AltName: Full=Mnh complex subunit C1;
GN   Name=mnhC1; OrderedLocusNames=SAB0817c;
OS   Staphylococcus aureus (strain bovine RF122 / ET3-1).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=273036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=bovine RF122 / ET3-1;
RX   PubMed=17971880; DOI=10.1371/journal.pone.0001120;
RA   Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.;
RT   "Molecular correlates of host specialization in Staphylococcus aureus.";
RL   PLoS ONE 2:E1120-E1120(2007).
CC   -!- FUNCTION: Mnh complex is a Na(+)/H(+) antiporter involved in Na(+)
CC       excretion. {ECO:0000250}.
CC   -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC       subunits: mnhA1, mnhB1, mnhC1, mnhD1, mnhE1, mnhF1 and mnhG1.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit C
CC       family. {ECO:0000305}.
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DR   EMBL; AJ938182; CAI80505.1; -; Genomic_DNA.
DR   RefSeq; WP_000402803.1; NC_007622.1.
DR   AlphaFoldDB; Q2YWT6; -.
DR   SMR; Q2YWT6; -.
DR   GeneID; 66839148; -.
DR   KEGG; sab:SAB0817c; -.
DR   HOGENOM; CLU_082058_3_1_9; -.
DR   OMA; YRVYEEH; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR006673; Mnh_C1_su.
DR   InterPro; IPR039428; NUOK/Mnh_C1-like.
DR   Pfam; PF00420; Oxidored_q2; 1.
DR   TIGRFAMs; TIGR00941; 2a6301s03; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Hydrogen ion transport; Ion transport; Membrane;
KW   Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..113
FT                   /note="Na(+)/H(+) antiporter subunit C1"
FT                   /id="PRO_0000372117"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   113 AA;  12293 MW;  094DCCA526E23835 CRC64;
     MEIIMIFVSG ILTAISVYLV LSKSLIRIVM GTTLLTHAAN LFLITMGGLK HGTVPIYEAN
     VKSYVDPIPQ ALILTAIVIA FATTAFFLVL AFRTYKELGT DNVESMKGVP EDD