ID   MNHC1_STAAC             Reviewed;         113 AA.
AC   Q5HHD5;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 101.
DE   RecName: Full=Na(+)/H(+) antiporter subunit C1;
DE   AltName: Full=Mnh complex subunit C1;
GN   Name=mnhC1; OrderedLocusNames=SACOL0953;
OS   Staphylococcus aureus (strain COL).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93062;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=COL;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Mnh complex is a Na(+)/H(+) antiporter involved in Na(+)
CC       excretion. {ECO:0000250}.
CC   -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC       subunits: mnhA1, mnhB1, mnhC1, mnhD1, mnhE1, mnhF1 and mnhG1.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit C
CC       family. {ECO:0000305}.
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DR   EMBL; CP000046; AAW37921.1; -; Genomic_DNA.
DR   RefSeq; WP_000402803.1; NC_002951.2.
DR   AlphaFoldDB; Q5HHD5; -.
DR   SMR; Q5HHD5; -.
DR   EnsemblBacteria; AAW37921; AAW37921; SACOL0953.
DR   GeneID; 66839148; -.
DR   KEGG; sac:SACOL0953; -.
DR   HOGENOM; CLU_082058_3_1_9; -.
DR   OMA; YRVYEEH; -.
DR   Proteomes; UP000000530; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR006673; Mnh_C1_su.
DR   InterPro; IPR039428; NUOK/Mnh_C1-like.
DR   Pfam; PF00420; Oxidored_q2; 1.
DR   TIGRFAMs; TIGR00941; 2a6301s03; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Hydrogen ion transport; Ion transport; Membrane;
KW   Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..113
FT                   /note="Na(+)/H(+) antiporter subunit C1"
FT                   /id="PRO_0000089147"
FT   TRANSMEM        4..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   113 AA;  12293 MW;  094DCCA526E23835 CRC64;
     MEIIMIFVSG ILTAISVYLV LSKSLIRIVM GTTLLTHAAN LFLITMGGLK HGTVPIYEAN
     VKSYVDPIPQ ALILTAIVIA FATTAFFLVL AFRTYKELGT DNVESMKGVP EDD