MNHC1_STAAE
ID MNHC1_STAAE Reviewed; 113 AA.
AC A6QFG0;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 05-MAY-2009, sequence version 2.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Na(+)/H(+) antiporter subunit C1;
DE AltName: Full=Mnh complex subunit C1;
GN Name=mnhC1; OrderedLocusNames=NWMN_0820;
OS Staphylococcus aureus (strain Newman).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=426430;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Newman;
RX PubMed=17951380; DOI=10.1128/jb.01000-07;
RA Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.;
RT "Genome sequence of Staphylococcus aureus strain Newman and comparative
RT analysis of staphylococcal genomes: polymorphism and evolution of two major
RT pathogenicity islands.";
RL J. Bacteriol. 190:300-310(2008).
CC -!- FUNCTION: Mnh complex is a Na(+)/H(+) antiporter involved in Na(+)
CC excretion. {ECO:0000250}.
CC -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC subunits: mnhA1, mnhB1, mnhC1, mnhD1, mnhE1, mnhF1 and mnhG1.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit C
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAF67092.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP009351; BAF67092.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_000402803.1; NC_009641.1.
DR AlphaFoldDB; A6QFG0; -.
DR SMR; A6QFG0; -.
DR EnsemblBacteria; BAF67092; BAF67092; NWMN_0820.
DR GeneID; 66839148; -.
DR KEGG; sae:NWMN_0820; -.
DR HOGENOM; CLU_082058_3_1_9; -.
DR Proteomes; UP000006386; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR006673; Mnh_C1_su.
DR InterPro; IPR039428; NUOK/Mnh_C1-like.
DR Pfam; PF00420; Oxidored_q2; 1.
DR TIGRFAMs; TIGR00941; 2a6301s03; 1.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Hydrogen ion transport; Ion transport; Membrane;
KW Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..113
FT /note="Na(+)/H(+) antiporter subunit C1"
FT /id="PRO_0000372122"
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 113 AA; 12293 MW; 094DCCA526E23835 CRC64;
MEIIMIFVSG ILTAISVYLV LSKSLIRIVM GTTLLTHAAN LFLITMGGLK HGTVPIYEAN
VKSYVDPIPQ ALILTAIVIA FATTAFFLVL AFRTYKELGT DNVESMKGVP EDD