ARLY_SYNPW
ID ARLY_SYNPW Reviewed; 470 AA.
AC A5GHM4;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-JUN-2007, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Argininosuccinate lyase {ECO:0000255|HAMAP-Rule:MF_00006};
DE Short=ASAL {ECO:0000255|HAMAP-Rule:MF_00006};
DE EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE AltName: Full=Arginosuccinase {ECO:0000255|HAMAP-Rule:MF_00006};
GN Name=argH {ECO:0000255|HAMAP-Rule:MF_00006};
GN OrderedLocusNames=SynWH7803_0013;
OS Synechococcus sp. (strain WH7803).
OC Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC unclassified Synechococcus.
OX NCBI_TaxID=32051;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WH7803;
RG Genoscope;
RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00006};
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000255|HAMAP-
CC Rule:MF_00006}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
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DR EMBL; CT971583; CAK22439.1; -; Genomic_DNA.
DR RefSeq; WP_011931948.1; NC_009481.1.
DR AlphaFoldDB; A5GHM4; -.
DR SMR; A5GHM4; -.
DR STRING; 32051.SynWH7803_0013; -.
DR EnsemblBacteria; CAK22439; CAK22439; SynWH7803_0013.
DR KEGG; syx:SynWH7803_0013; -.
DR eggNOG; COG0165; Bacteria.
DR HOGENOM; CLU_027272_2_3_3; -.
DR OMA; KKNPDVF; -.
DR OrthoDB; 751464at2; -.
DR UniPathway; UPA00068; UER00114.
DR Proteomes; UP000001566; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR CDD; cd01359; Argininosuccinate_lyase; 1.
DR Gene3D; 1.10.275.10; -; 1.
DR HAMAP; MF_00006; Arg_succ_lyase; 1.
DR InterPro; IPR029419; Arg_succ_lyase_C.
DR InterPro; IPR009049; Argininosuccinate_lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR PANTHER; PTHR43814; PTHR43814; 1.
DR Pfam; PF14698; ASL_C2; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; SSF48557; 1.
DR TIGRFAMs; TIGR00838; argH; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; Lyase;
KW Reference proteome.
FT CHAIN 1..470
FT /note="Argininosuccinate lyase"
FT /id="PRO_1000000550"
SQ SEQUENCE 470 AA; 51785 MW; 14DA5929CB9AE85D CRC64;
MAGGVTGGGS ATWSDRFEQG LHPAIERFNA SIGFDITLLQ EDLDGSMAHA RMLAQCGVIS
EAEADQLCGG LEQIRAEAAE GRFQPGLDDE DVHFAVERRL IALLGPVGKK LHTGRSRNDQ
VGTDLRLWLR RRIDELIPQV KTFQRALLRQ ALSHRRTLIP GYTHLQRAQP VCLAHHLLAY
VEMLERDRQR LEDVRKRVNV SPLGAAALAG TPVPIDRRST AAALGFDGLY ANSLDAVSDR
DFAVEFSAAI SLVMVHLSRL GEEVIFWASE ECGFVRLSDR CATGSSLMPQ KKNPDVPELV
RGKCGRVFGH LQGLLTMIKG LPLAYNKDFQ EDKEALFDVV STGSQCLEAM TILMDEGLSF
REDRLEAAVA ADFSNATDVA DYLVARQVPF REAYQIVGSV VKQCLSEGVL LRDLSLERWQ
SFHPAIESDL YDALAPRQVV AARTSEGGTG FDRVEEQLSA WSERLDLANG
