ID   MNHC2_STAAT             Reviewed;         114 AA.
AC   A8Z146;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Putative antiporter subunit mnhC2;
DE   AltName: Full=Mrp complex subunit C2;
DE   AltName: Full=Putative NADH-ubiquinone oxidoreductase subunit mnhC2;
GN   Name=mnhC2; Synonyms=mrpC2; OrderedLocusNames=USA300HOU_0645;
OS   Staphylococcus aureus (strain USA300 / TCH1516).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=451516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USA300 / TCH1516;
RX   PubMed=17986343; DOI=10.1186/1471-2180-7-99;
RA   Highlander S.K., Hulten K.G., Qin X., Jiang H., Yerrapragada S.,
RA   Mason E.O. Jr., Shang Y., Williams T.M., Fortunov R.M., Liu Y., Igboeli O.,
RA   Petrosino J., Tirumalai M., Uzman A., Fox G.E., Cardenas A.M., Muzny D.M.,
RA   Hemphill L., Ding Y., Dugan S., Blyth P.R., Buhay C.J., Dinh H.H.,
RA   Hawes A.C., Holder M., Kovar C.L., Lee S.L., Liu W., Nazareth L.V.,
RA   Wang Q., Zhou J., Kaplan S.L., Weinstock G.M.;
RT   "Subtle genetic changes enhance virulence of methicillin resistant and
RT   sensitive Staphylococcus aureus.";
RL   BMC Microbiol. 7:99-99(2007).
CC   -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC       subunits: mnhA2, mnhB2, mnhC2, mnhD2, mnhE2, mnhF2 and mnhG2.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit C
CC       family. {ECO:0000305}.
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DR   EMBL; CP000730; ABX28667.1; -; Genomic_DNA.
DR   RefSeq; WP_001048985.1; NC_010079.1.
DR   AlphaFoldDB; A8Z146; -.
DR   SMR; A8Z146; -.
DR   KEGG; sax:USA300HOU_0645; -.
DR   HOGENOM; CLU_082058_3_1_9; -.
DR   OMA; AIYMMLR; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR039428; NUOK/Mnh_C1-like.
DR   Pfam; PF00420; Oxidored_q2; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Ion transport; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..114
FT                   /note="Putative antiporter subunit mnhC2"
FT                   /id="PRO_0000372260"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        28..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   114 AA;  12496 MW;  530D8DC7C28622BC CRC64;
     MNLILLLVIG FLVFIGTYMI LSINLIRIVI GISIYTHAGN LIIMSMGTYG SSRSEPLITG
     GNQLFVDPLL QAIVLTAIVI GFGMTAFLLV LVYRTYKVTK EDEIEGLRGE DDAK