ARLY_SYNS9
ID ARLY_SYNS9 Reviewed; 472 AA.
AC Q3B0Z0;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 2.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Argininosuccinate lyase {ECO:0000255|HAMAP-Rule:MF_00006};
DE Short=ASAL {ECO:0000255|HAMAP-Rule:MF_00006};
DE EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE AltName: Full=Arginosuccinase {ECO:0000255|HAMAP-Rule:MF_00006};
GN Name=argH {ECO:0000255|HAMAP-Rule:MF_00006};
GN OrderedLocusNames=Syncc9902_0013;
OS Synechococcus sp. (strain CC9902).
OC Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus;
OC unclassified Synechococcus.
OX NCBI_TaxID=316279;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CC9902;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Martinez M., Schmutz J., Larimer F.,
RA Land M., Kyrpides N., Ivanova N., Richardson P.;
RT "Complete sequence of Synechococcus sp. CC9902.";
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00006};
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000255|HAMAP-
CC Rule:MF_00006}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ABB24988.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CP000097; ABB24988.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_011358858.1; NC_007513.1.
DR AlphaFoldDB; Q3B0Z0; -.
DR SMR; Q3B0Z0; -.
DR STRING; 316279.Syncc9902_0013; -.
DR PRIDE; Q3B0Z0; -.
DR EnsemblBacteria; ABB24988; ABB24988; Syncc9902_0013.
DR KEGG; sye:Syncc9902_0013; -.
DR eggNOG; COG0165; Bacteria.
DR HOGENOM; CLU_027272_2_3_3; -.
DR OrthoDB; 751464at2; -.
DR UniPathway; UPA00068; UER00114.
DR Proteomes; UP000002712; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR CDD; cd01359; Argininosuccinate_lyase; 1.
DR Gene3D; 1.10.275.10; -; 1.
DR HAMAP; MF_00006; Arg_succ_lyase; 1.
DR InterPro; IPR029419; Arg_succ_lyase_C.
DR InterPro; IPR009049; Argininosuccinate_lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR PANTHER; PTHR43814; PTHR43814; 1.
DR Pfam; PF14698; ASL_C2; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; SSF48557; 1.
DR TIGRFAMs; TIGR00838; argH; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; Lyase;
KW Reference proteome.
FT CHAIN 1..472
FT /note="Argininosuccinate lyase"
FT /id="PRO_0000240781"
SQ SEQUENCE 472 AA; 52211 MW; 7F0D7D1038FA4317 CRC64;
MAGGVTGGAD GTWSDRFEQG LHPFIEVFNA SIGFDLTLLQ EDLDGSIAHA RMLGSCGVIS
VEEAEQLVQG LETIRSEAHA GTFQPGLADE DVHFAVERRL IALLGPVGKK LHTGRSRNDQ
VGTDLRLWLR RRLDELEGDL QRLQRALVAQ ADLHRRTMIP GYTHLQRAQP LCLAHHLLAY
VEMLERDRLR LHDVRSRVNI CPLGAAALAG TPVPIDRQQT AKALGFDAIY ANSLDAVSDR
DFCVEFSAAA SLVMAHLSRL AEEVIAWASE EFRFVRLSDR CATGSSLMPQ KKNPDVPELV
RGKCGRVFGH LQGLLTMIKG LPLAYNKDFQ EDKEALFDAF RTTRDCIEAM AILFEEGLEF
RTERLNTAVE QDFSNATDVA DYLVAKGVPF REAYQLVGAV VRRCLDEGCL LRDLSLAAWQ
ELHPAFEADL HDALAPQAVV AARRSEGGTG FDRVDEQLGR WLQHLNGTQP VG
