ID   MNHD1_STAA3             Reviewed;         498 AA.
AC   Q2FIC6;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Na(+)/H(+) antiporter subunit D1;
DE   AltName: Full=Mnh complex subunit D1;
GN   Name=mnhD1; OrderedLocusNames=SAUSA300_0852;
OS   Staphylococcus aureus (strain USA300).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=367830;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USA300;
RX   PubMed=16517273; DOI=10.1016/s0140-6736(06)68231-7;
RA   Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA   Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA   Perdreau-Remington F.;
RT   "Complete genome sequence of USA300, an epidemic clone of community-
RT   acquired meticillin-resistant Staphylococcus aureus.";
RL   Lancet 367:731-739(2006).
CC   -!- FUNCTION: Mnh complex is a Na(+)/H(+) antiporter involved in Na(+)
CC       excretion. {ECO:0000250}.
CC   -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC       subunits: mnhA1, mnhB1, mnhC1, mnhD1, mnhE1, mnhF1 and mnhG1.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D
CC       family. {ECO:0000305}.
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DR   EMBL; CP000255; ABD21259.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q2FIC6; -.
DR   SMR; Q2FIC6; -.
DR   EnsemblBacteria; ABD21259; ABD21259; SAUSA300_0852.
DR   KEGG; saa:SAUSA300_0852; -.
DR   HOGENOM; CLU_007100_9_2_9; -.
DR   OMA; YVAHHIT; -.
DR   Proteomes; UP000001939; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR   GO; GO:0015386; F:potassium:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR004775; MnhD1.
DR   InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   PRINTS; PR01437; NUOXDRDTASE4.
DR   TIGRFAMs; TIGR00944; 2a6301s04; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Hydrogen ion transport; Ion transport; Membrane;
KW   Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..498
FT                   /note="Na(+)/H(+) antiporter subunit D1"
FT                   /id="PRO_0000372136"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        75..95
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        278..298
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        303..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        338..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        407..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        455..475
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   498 AA;  54772 MW;  31231A7EEED00E64 CRC64;
     MIESNMLVLT LVIPVITAIL LVFIGKRPII KRYVALGGTL LTLVAAIINL ANVVKHGPIR
     VELGSWKAPY SIVFVLDIFS ALLIITSIII TAIVILYSYQ TIGIERERYY YYFSVLFMLI
     GIIGAFTTGD IFNLFVYFEV FLMSSYFLLV IGSTKIQLQE TIKYVLVNVV SSSFFVMGVA
     ILYSVVGTLN LADISNKLAN LSAHDSGLVN IVFILFIFVF ATKAGVFPMF VWLPSAYYAP
     PIPIIAFFGA LLTKVGVYAI ARTLSLFFSD NVSFSHYVIL FLALLTIIFG CVGAVAYANI
     KKIILYNVMI AVGVILVGVA MMTESGMIGA IYYTLHDMLV KLALFLLIGI MIKITGTADL
     RQFGGLIKRY PVLGWSFFIA ALSLAGIPPL SGFYGKFFIV QSTFERGFYL SGVIVLLSSL
     VVLYSVIRIF LQGFFGQPKG YDLNNKVDVK YLTTIAIVAV VITVLYGLSA DYLYPMVKAG
     AETFYNPSTY VKAVLGGK