ID   MNHD1_STAHJ             Reviewed;         499 AA.
AC   Q4L4W4;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=Na+/H+-antiporter, MnhD subunit;
GN   Name=mnhD; OrderedLocusNames=SH2002;
OS   Staphylococcus haemolyticus (strain JCSC1435).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=279808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCSC1435;
RX   PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA   Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA   Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA   Hiramatsu K.;
RT   "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT   extreme plasticity of its genome and the evolution of human-colonizing
RT   staphylococcal species.";
RL   J. Bacteriol. 187:7292-7308(2005).
CC   -!- FUNCTION: Mnh complex is a Na(+)/H(+) antiporter involved in Na(+)
CC       excretion. {ECO:0000250}.
CC   -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC       subunits: mnhA1, mnhB1, mnhC1, mnhD1, mnhE1, mnhF1 and mnhG1.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D
CC       family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP006716; BAE05311.1; -; Genomic_DNA.
DR   RefSeq; WP_011276269.1; NC_007168.1.
DR   AlphaFoldDB; Q4L4W4; -.
DR   SMR; Q4L4W4; -.
DR   STRING; 279808.SH2002; -.
DR   EnsemblBacteria; BAE05311; BAE05311; SH2002.
DR   GeneID; 58061889; -.
DR   KEGG; sha:SH2002; -.
DR   eggNOG; COG0651; Bacteria.
DR   HOGENOM; CLU_007100_9_2_9; -.
DR   OMA; YVAHHIT; -.
DR   OrthoDB; 1887859at2; -.
DR   Proteomes; UP000000543; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   PRINTS; PR01437; NUOXDRDTASE4.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Hydrogen ion transport; Ion transport; Membrane;
KW   Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..499
FT                   /note="Na+/H+-antiporter, MnhD subunit"
FT                   /id="PRO_0000372139"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        72..92
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        169..189
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        207..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        303..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        327..347
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        410..430
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        457..477
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   499 AA;  54885 MW;  E7079712652C66CF CRC64;
     MIENNLVVLS LVVPIFTAII LVFLGQRYRA KRYVTLTGLV LTLIVAIINL RNVYVDGPLK
     VELGSWPAPY GIIFLLDSFS AMLIVTSIII TILITAFSST TAGIDRERYY YHFSITFMLV
     GIIGAFTTGD IFNLFVFFEV FLMSSYALLV LGGTQIQLRE TVKYLLVNIV TSTFFVIAVA
     ILYSIVGTLN MADISEKLST LSNTHGGLLS IVFILFIFVF ATKAGAFPMY VWLPGSYYAP
     PFAIIAFFGA LLTKVGVYAI LRTLSLFFHN TMSFSHYTIL FLALLTIIFG SVGAIAYDDT
     KKIIIYNIMI AVGVILVGVA MMNEAGIIGA IYYTIHDMLV KTALFLLIGV MYQITKSTSL
     KDFGGLIKHY PVLGWTFFIA ALSLAGIPPL SGFYGKYYIV QATFEKGFYV SGIIVLLSSL
     VVLYSVIHIF LKGFFGKPKG YEPTQSVNVK HATTISIIAV VITVVFGLSA DLLYPLISEA
     AQSFYDPSIY IESVLGGRS