MNHD2_STAA9
ID MNHD2_STAA9 Reviewed; 498 AA.
AC A5IQH8;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2007, sequence version 1.
DT 25-MAY-2022, entry version 81.
DE RecName: Full=Putative antiporter subunit mnhD2;
DE AltName: Full=Mrp complex subunit D2;
DE AltName: Full=Putative NADH-ubiquinone oxidoreductase subunit mnhD2;
GN Name=mnhD2; Synonyms=mrpD2; OrderedLocusNames=SaurJH9_0648;
OS Staphylococcus aureus (strain JH9).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=359786;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JH9;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P.,
RA Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Kim E., Tomasz A., Richardson P.;
RT "Complete sequence of chromosome of Staphylococcus aureus subsp. aureus
RT JH9.";
RL Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC subunits: mnhA2, mnhB2, mnhC2, mnhD2, mnhE2, mnhF2 and mnhG2.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D
CC family. {ECO:0000305}.
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DR EMBL; CP000703; ABQ48451.1; -; Genomic_DNA.
DR RefSeq; WP_000950548.1; NC_009487.1.
DR AlphaFoldDB; A5IQH8; -.
DR SMR; A5IQH8; -.
DR KEGG; saj:SaurJH9_0648; -.
DR HOGENOM; CLU_007100_9_2_9; -.
DR OMA; NAWAPDA; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR InterPro; IPR001750; ND/Mrp_mem.
DR Pfam; PF00361; Proton_antipo_M; 1.
DR PRINTS; PR01437; NUOXDRDTASE4.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Ion transport; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..498
FT /note="Putative antiporter subunit mnhD2"
FT /id="PRO_0000372232"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 108..128
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 161..181
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..328
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 403..423
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 451..471
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 498 AA; 55153 MW; FCD3275F3B7BFA79 CRC64;
MLSNLLILPM LLPFLCALIL VFLKNNDRIS KYLYLGTMTI TTIISLMLLI YVQRHRPITL
DFGGWSAPFG IQFLGDSLSL IMVTTASFVI TLIMAYGFGR GEHKANRYHL PSFILFLSVG
VIGSFLTSDL FNLYVMFEIM LLASFVLITL GQSVEQLRAA IIYVVLNIIG SWLFLLGIGL
LYKTVGTLNF SHIAMRLNDM GDNRTVTMIS LIFLVAFSAK AALVLFMWLP KAYAVLNTEL
AALFAALMTK VGAYALIRFF TLLFDQHNDL IHPLLATMAA ITMVIGAIGV IAYKDIKKIA
AYQVIISIGF IILGLGTNTF AGINGAIFYL VNDIVVKTLL FFIIGSLVYI TGYRQYQYLN
GLAKKEPLFG VAFIIMIFAI GGVPPFSGFP GKVLIFQGAL QNGNYIGLAL MIITSLIAMY
SLFRILFYMY FGDKDGEEVN FKKIPLYRKR ILSILVVVVI AIGIAAPVVL NVTSDATELN
TSDQLYQKLV NPHLKGED