ID   MNHD2_STAAT             Reviewed;         498 AA.
AC   A8Z147;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Putative antiporter subunit mnhD2;
DE   AltName: Full=Mrp complex subunit D2;
DE   AltName: Full=Putative NADH-ubiquinone oxidoreductase subunit mnhD2;
GN   Name=mnhD2; Synonyms=mrpD2; OrderedLocusNames=USA300HOU_0646;
OS   Staphylococcus aureus (strain USA300 / TCH1516).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=451516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USA300 / TCH1516;
RX   PubMed=17986343; DOI=10.1186/1471-2180-7-99;
RA   Highlander S.K., Hulten K.G., Qin X., Jiang H., Yerrapragada S.,
RA   Mason E.O. Jr., Shang Y., Williams T.M., Fortunov R.M., Liu Y., Igboeli O.,
RA   Petrosino J., Tirumalai M., Uzman A., Fox G.E., Cardenas A.M., Muzny D.M.,
RA   Hemphill L., Ding Y., Dugan S., Blyth P.R., Buhay C.J., Dinh H.H.,
RA   Hawes A.C., Holder M., Kovar C.L., Lee S.L., Liu W., Nazareth L.V.,
RA   Wang Q., Zhou J., Kaplan S.L., Weinstock G.M.;
RT   "Subtle genetic changes enhance virulence of methicillin resistant and
RT   sensitive Staphylococcus aureus.";
RL   BMC Microbiol. 7:99-99(2007).
CC   -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC       subunits: mnhA2, mnhB2, mnhC2, mnhD2, mnhE2, mnhF2 and mnhG2.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D
CC       family. {ECO:0000305}.
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DR   EMBL; CP000730; ABX28668.1; -; Genomic_DNA.
DR   RefSeq; WP_000950548.1; NC_010079.1.
DR   AlphaFoldDB; A8Z147; -.
DR   SMR; A8Z147; -.
DR   KEGG; sax:USA300HOU_0646; -.
DR   HOGENOM; CLU_007100_9_2_9; -.
DR   OMA; NAWAPDA; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   PRINTS; PR01437; NUOXDRDTASE4.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Ion transport; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..498
FT                   /note="Putative antiporter subunit mnhD2"
FT                   /id="PRO_0000372241"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..291
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        308..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        330..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        369..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        403..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        451..471
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   498 AA;  55153 MW;  FCD3275F3B7BFA79 CRC64;
     MLSNLLILPM LLPFLCALIL VFLKNNDRIS KYLYLGTMTI TTIISLMLLI YVQRHRPITL
     DFGGWSAPFG IQFLGDSLSL IMVTTASFVI TLIMAYGFGR GEHKANRYHL PSFILFLSVG
     VIGSFLTSDL FNLYVMFEIM LLASFVLITL GQSVEQLRAA IIYVVLNIIG SWLFLLGIGL
     LYKTVGTLNF SHIAMRLNDM GDNRTVTMIS LIFLVAFSAK AALVLFMWLP KAYAVLNTEL
     AALFAALMTK VGAYALIRFF TLLFDQHNDL IHPLLATMAA ITMVIGAIGV IAYKDIKKIA
     AYQVIISIGF IILGLGTNTF AGINGAIFYL VNDIVVKTLL FFIIGSLVYI TGYRQYQYLN
     GLAKKEPLFG VAFIIMIFAI GGVPPFSGFP GKVLIFQGAL QNGNYIGLAL MIITSLIAMY
     SLFRILFYMY FGDKDGEEVN FKKIPLYRKR ILSILVVVVI AIGIAAPVVL NVTSDATELN
     TSDQLYQKLV NPHLKGED