ID   MNHD2_STAEQ             Reviewed;         499 AA.
AC   Q5HRA9;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Putative antiporter subunit mnhD2;
DE   AltName: Full=Mrp complex subunit D2;
DE   AltName: Full=Putative NADH-ubiquinone oxidoreductase subunit mnhD2;
GN   Name=mnhD2; Synonyms=mrpD2; OrderedLocusNames=SERP0284;
OS   Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35984 / RP62A;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC       subunits: mnhA2, mnhB2, mnhC2, mnhD2, mnhE2, mnhF2 and mnhG2.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D
CC       family. {ECO:0000305}.
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DR   EMBL; CP000029; AAW53727.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q5HRA9; -.
DR   SMR; Q5HRA9; -.
DR   STRING; 176279.SERP0284; -.
DR   EnsemblBacteria; AAW53727; AAW53727; SERP0284.
DR   KEGG; ser:SERP0284; -.
DR   eggNOG; COG0651; Bacteria.
DR   HOGENOM; CLU_007100_9_2_9; -.
DR   OMA; NAWAPDA; -.
DR   Proteomes; UP000000531; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   PRINTS; PR01437; NUOXDRDTASE4.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..499
FT                   /note="Putative antiporter subunit mnhD2"
FT                   /id="PRO_0000372244"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        77..97
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        307..327
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        329..349
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        367..387
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        402..422
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        449..469
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   499 AA;  55079 MW;  8C60272D50429C8E CRC64;
     MSNLIILPML LPFVCALILV FTKNKNRISK ILSITTMIVN TMISIALLIY VVNHKPITLD
     FGGWKAPFGI QFLGDSLSLL MVSVSSFVVT LIMAYGFGRG EKRVNRFHLP TFILLLTVGV
     IGSFLTSDLF NLYVMFEIML LASFVLVTLG QSVEQLRAAI VYVVLNILGS WLLLLGIGML
     YKTVGTLNFS HLAMRLNHME NNQTITMISL VFLVAFSSKA ALVIFMWLPK AYAVLNTELA
     ALFAALMTKV GAYALIRFFT LLFDHHPSVT HTLLVFMACI TMIIGAFGVI AYKDIKKIAA
     YQVILSIGFI ILGLGSHTIS GVNGAIFYLA NDIIVKTLLF FVIGSLVYMS GYRNYQYLSG
     LAKREPFFGV AFVVVIFAIG GVPPFSGFPG KVLIFQGAIT NGNYIGLALM IVTSLIAMYS
     LFRVMFIMYF GDADGEQVQF RPLPIYRKGL LSVLVVVVLA MGIAAPVVLK VTEDATNLNM
     KEDVFQKNVN THLKEVNHK