ID   MNHD2_STAES             Reviewed;         500 AA.
AC   Q8CQ47;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Putative antiporter subunit mnhD2;
DE   AltName: Full=Mrp complex subunit D2;
DE   AltName: Full=Putative NADH-ubiquinone oxidoreductase subunit mnhD2;
GN   Name=mnhD2; Synonyms=mrpD2; OrderedLocusNames=SE_0400;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC       subunits: mnhA2, mnhB2, mnhC2, mnhD2, mnhE2, mnhF2 and mnhG2.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D
CC       family. {ECO:0000305}.
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DR   EMBL; AE015929; AAO03997.1; -; Genomic_DNA.
DR   RefSeq; NP_763955.1; NC_004461.1.
DR   RefSeq; WP_011082609.1; NZ_WBME01000020.1.
DR   AlphaFoldDB; Q8CQ47; -.
DR   SMR; Q8CQ47; -.
DR   STRING; 176280.SE_0400; -.
DR   EnsemblBacteria; AAO03997; AAO03997; SE_0400.
DR   GeneID; 50019443; -.
DR   KEGG; sep:SE_0400; -.
DR   PATRIC; fig|176280.10.peg.374; -.
DR   eggNOG; COG0651; Bacteria.
DR   HOGENOM; CLU_007100_9_2_9; -.
DR   OMA; NAWAPDA; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   PRINTS; PR01437; NUOXDRDTASE4.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Ion transport; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..500
FT                   /note="Putative antiporter subunit mnhD2"
FT                   /id="PRO_0000372243"
FT   TRANSMEM        2..22
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        308..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        330..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        368..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        403..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        450..470
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   500 AA;  55211 MW;  4C602738FCE0D5AA CRC64;
     MMSNLIILPM LLPFVCALIL VFTKNKNRIS KILSITTMIV NTMISIALLI YVVNHKPITL
     DFGGWKAPFG IQFLGDSLSL LMVSVSSFVV TLIMAYGFGR GEKRVNRFHL PTFILLLTVG
     VIGSFLTSDL FNLYVMFEIM LLASFVLVTL GQSVEQLRAA IVYVVLNILG SWLLLLGIGM
     LYKTVGTLNF SHLAMRLNHM ENNQTITMIS LVFLVAFSSK AALVIFMWLP KAYAVLNTEL
     AALFAALMTK VGAYALIRFF TLLFDHHPSV THTLLVFMAC ITMIIGAFGV IAYKDIKKIA
     AYQVILSIGF IILGLGSHTI SGVNGAIFYL ANDIIVKTLL FFVIGSLVYM SGYRNYQYLS
     GLAKREPFFG VAFVVVIFAI GGVPPFSGFP GKVLIFQGAI TNGNYIGLAL MIVTSLIAMY
     SLFRVMFIMY FGDADGEQVQ FRPLPIYRKG LLSVLVVVVL AMGIAAPVVL KVTEDATNLN
     MKEDVFQKNV NTHLKEVNHK