ID   MNHD2_STAHJ             Reviewed;         499 AA.
AC   Q4L446;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Putative antiporter subunit mnhD2;
DE   AltName: Full=Mrp complex subunit D2;
DE   AltName: Full=Putative NADH-ubiquinone oxidoreductase subunit mnhD2;
GN   Name=mnhD2; Synonyms=mrpD2; OrderedLocusNames=SH2272;
OS   Staphylococcus haemolyticus (strain JCSC1435).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=279808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCSC1435;
RX   PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA   Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA   Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA   Hiramatsu K.;
RT   "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT   extreme plasticity of its genome and the evolution of human-colonizing
RT   staphylococcal species.";
RL   J. Bacteriol. 187:7292-7308(2005).
CC   -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC       subunits: mnhA2, mnhB2, mnhC2, mnhD2, mnhE2, mnhF2 and mnhG2.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D
CC       family. {ECO:0000305}.
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DR   EMBL; AP006716; BAE05581.1; -; Genomic_DNA.
DR   RefSeq; WP_011276531.1; NC_007168.1.
DR   AlphaFoldDB; Q4L446; -.
DR   SMR; Q4L446; -.
DR   STRING; 279808.SH2272; -.
DR   EnsemblBacteria; BAE05581; BAE05581; SH2272.
DR   GeneID; 58061608; -.
DR   KEGG; sha:SH2272; -.
DR   eggNOG; COG0651; Bacteria.
DR   HOGENOM; CLU_007100_9_2_9; -.
DR   OMA; NAWAPDA; -.
DR   OrthoDB; 1887859at2; -.
DR   Proteomes; UP000000543; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   PRINTS; PR01437; NUOXDRDTASE4.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Ion transport; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..499
FT                   /note="Putative antiporter subunit mnhD2"
FT                   /id="PRO_0000372245"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        130..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        206..226
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        308..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        330..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        368..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        403..423
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        450..470
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   499 AA;  54968 MW;  1D24AB5B55994768 CRC64;
     MNSNLLVLPI LLPLLCALVL VFTKEKNRLS KILYIGTMSV NTVISLCLLI YVLQHKPITL
     DFGGWAAPYG IQFLGDSLSL VMVTVASFVV TLIMSYGFGR GEDRVNRYYL PTFILFLTTG
     VIGSFLTSDL FNLYVMFEIM LLASFVLVTL GQSVEQLRAA IIYVVLNIVG SWLFLLGIGL
     LYKTVGTLNF SQVALRLDQI HDNKAIIIIS IVFIVAFGSK AALVLFMWLP KAYAVLNTEL
     AALFAALMTK VGAYALIRFF TLLFDQHTGV THPLLVFMSC ITMLIGAFGV IAYRDIKKVA
     SYQVILSIGF VILGLGSNTF AGVHGAIFYL ANDIIVKTML FFIIGSLVYM SGYREYKYLC
     GLAKKEPFFG VAFVVMIFAI GGVPPFSGFP GKVLIFQGAI ENGNFIGLAL MIITSLLAMY
     SLFRILFIMY FGDNDGEQVD FNPLPKHRKT ILGILVAVVL AMGIAAPVVM NATENATKLN
     MDDNYFHSIV NSHLKEGNK