ID   MNHD2_STAS1             Reviewed;         501 AA.
AC   Q49VH2;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Putative antiporter subunit mnhD2;
DE   AltName: Full=Mrp complex subunit D2;
DE   AltName: Full=Putative NADH-ubiquinone oxidoreductase subunit mnhD2;
GN   Name=mnhD2; Synonyms=mrpD2; OrderedLocusNames=SSP2093;
OS   Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS   20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=342451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX   PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA   Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA   Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT   "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT   pathogenesis of uncomplicated urinary tract infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC   -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC       subunits: mnhA2, mnhB2, mnhC2, mnhD2, mnhE2, mnhF2 and mnhG2.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D
CC       family. {ECO:0000305}.
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DR   EMBL; AP008934; BAE19238.1; -; Genomic_DNA.
DR   RefSeq; WP_011303735.1; NC_007350.1.
DR   AlphaFoldDB; Q49VH2; -.
DR   SMR; Q49VH2; -.
DR   STRING; 342451.SSP2093; -.
DR   EnsemblBacteria; BAE19238; BAE19238; SSP2093.
DR   KEGG; ssp:SSP2093; -.
DR   PATRIC; fig|342451.11.peg.2086; -.
DR   eggNOG; COG0651; Bacteria.
DR   HOGENOM; CLU_007100_9_2_9; -.
DR   OMA; NAWAPDA; -.
DR   Proteomes; UP000006371; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:InterPro.
DR   GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:InterPro.
DR   GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003918; NADH_UbQ_OxRdtase.
DR   InterPro; IPR001750; ND/Mrp_mem.
DR   Pfam; PF00361; Proton_antipo_M; 1.
DR   PRINTS; PR01437; NUOXDRDTASE4.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..501
FT                   /note="Putative antiporter subunit mnhD2"
FT                   /id="PRO_0000372246"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..99
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        207..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        245..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        309..329
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        334..354
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        369..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        409..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        452..472
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   501 AA;  55059 MW;  1C62A01880D30EAF CRC64;
     MLMSNLLILP LLLPAVCALG LVFIRTHSRL SRIFSIGTMA VTTVVSLLLL IYVMYHKPIA
     LDFGGWQAPF GIQFVGDSLS LLLVTTSSFV VTLIMAYGFG RTEKRAIRYY LPSFILFLTV
     GVIGSFLTAD LFNIYVMFEV MLLASFVLIT LGQSVEQLRA AIIYVVLNIL GSWLLLLGVG
     LLYKLTGTLN FTLVAQRLNE MDDKSSIVIV SMVFLIAFSA KAALVLFMWL PKAYAVLNTE
     LAALFAALMT KVGAYALIRF FTLIFDEHSG ITHPLLVFLS CITMLIGAFG VLAYRDIKKI
     AAYQVILSIG FIILGLGTNT IAGVNGAIFY LANDIVVKTL LFFIIGSLVY ITGLRQYKSL
     YGLAKQEPFF GVAFVVMILA IGGVPPFSGF PGKVFIFKGA IENGNYIGLA LMIITSLIAM
     FSLFRIFFVM YLGNENKGEA IVFNKIPTYR KNLIGVLVAM IIVMGLAAPL LFKVTDNATH
     LNMDDGLYEK MVNPHLIKGD K