ID   MNHE1_STAA8             Reviewed;         159 AA.
AC   Q2G2H8;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Na(+)/H(+) antiporter subunit E1;
DE   AltName: Full=Mnh complex subunit E1;
GN   Name=mnhE1; OrderedLocusNames=SAOUHSC_00885;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
CC   -!- FUNCTION: Mnh complex is a Na(+)/H(+) antiporter involved in Na(+)
CC       excretion. {ECO:0000250}.
CC   -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC       subunits: mnhA1, mnhB1, mnhC1, mnhD1, mnhE1, mnhF1 and mnhG1.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E
CC       family. {ECO:0000305}.
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DR   EMBL; CP000253; ABD30010.1; -; Genomic_DNA.
DR   RefSeq; WP_000290674.1; NZ_LS483365.1.
DR   RefSeq; YP_499438.1; NC_007795.1.
DR   AlphaFoldDB; Q2G2H8; -.
DR   SMR; Q2G2H8; -.
DR   STRING; 1280.SAXN108_0943; -.
DR   EnsemblBacteria; ABD30010; ABD30010; SAOUHSC_00885.
DR   GeneID; 3919232; -.
DR   KEGG; sao:SAOUHSC_00885; -.
DR   PATRIC; fig|93061.5.peg.805; -.
DR   eggNOG; COG1863; Bacteria.
DR   HOGENOM; CLU_086615_3_2_9; -.
DR   OMA; HAMDIED; -.
DR   PRO; PR:Q2G2H8; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR004847; Antiport_suE1.
DR   InterPro; IPR002758; Cation_antiport_E.
DR   PANTHER; PTHR34584; PTHR34584; 1.
DR   Pfam; PF01899; MNHE; 1.
DR   PIRSF; PIRSF019239; MrpE; 1.
DR   TIGRFAMs; TIGR00942; 2a6301s05; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Hydrogen ion transport; Ion transport; Membrane;
KW   Reference proteome; Sodium; Sodium transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..159
FT                   /note="Na(+)/H(+) antiporter subunit E1"
FT                   /id="PRO_0000372145"
FT   TRANSMEM        1..21
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..47
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   159 AA;  18319 MW;  95C11B67E678D3B7 CRC64;
     MAVQLVLNFI IAVFWLFVTN SYTTNNFVLG FIFGLVLVYL LHRVLPGRFY VITLYRIIKL
     VIIFLIELIK ANFDVLKIII KPSIKNEPGF FVYHTDLKKD WQIVLLSNLI TLTPGTVVLG
     VSDDRTKIYI HAIDFSTKEQ EVESIKTSLE KIVREVGEI