MNHE1_STAAB
ID MNHE1_STAAB Reviewed; 159 AA.
AC Q2YWT8;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Na(+)/H(+) antiporter subunit E1;
DE AltName: Full=Mnh complex subunit E1;
GN Name=mnhE1; OrderedLocusNames=SAB0815c;
OS Staphylococcus aureus (strain bovine RF122 / ET3-1).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=273036;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=bovine RF122 / ET3-1;
RX PubMed=17971880; DOI=10.1371/journal.pone.0001120;
RA Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.;
RT "Molecular correlates of host specialization in Staphylococcus aureus.";
RL PLoS ONE 2:E1120-E1120(2007).
CC -!- FUNCTION: Mnh complex is a Na(+)/H(+) antiporter involved in Na(+)
CC excretion. {ECO:0000250}.
CC -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC subunits: mnhA1, mnhB1, mnhC1, mnhD1, mnhE1, mnhF1 and mnhG1.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E
CC family. {ECO:0000305}.
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DR EMBL; AJ938182; CAI80503.1; -; Genomic_DNA.
DR RefSeq; WP_000290673.1; NC_007622.1.
DR AlphaFoldDB; Q2YWT8; -.
DR SMR; Q2YWT8; -.
DR KEGG; sab:SAB0815c; -.
DR HOGENOM; CLU_086615_3_2_9; -.
DR OMA; HAMDIED; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR004847; Antiport_suE1.
DR InterPro; IPR002758; Cation_antiport_E.
DR PANTHER; PTHR34584; PTHR34584; 1.
DR Pfam; PF01899; MNHE; 1.
DR PIRSF; PIRSF019239; MrpE; 1.
DR TIGRFAMs; TIGR00942; 2a6301s05; 1.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Hydrogen ion transport; Ion transport; Membrane;
KW Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..159
FT /note="Na(+)/H(+) antiporter subunit E1"
FT /id="PRO_0000372141"
FT TRANSMEM 1..21
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 159 AA; 18333 MW; 745208CC65C0E834 CRC64;
MAVQLVLNFI IAVFWLFVTN SYTTNNFVLG FIFGLVLVYL LHRVLPGRFY VITLYRIIKL
IIIFLIELIK ANFDVLKIII KPSIKNEPGF FVYHTDLKKD WQIVLLSNLI TLTPGTVVLG
VSDDRTKIYI HAIDFSTKEQ EVESIKTSLE KIVREVGEI