MNHE1_STAAM
ID MNHE1_STAAM Reviewed; 159 AA.
AC P60688; Q9ZNG2;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2004, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Na(+)/H(+) antiporter subunit E1;
DE AltName: Full=Mnh complex subunit E1;
GN Name=mnhE1; OrderedLocusNames=SAV0948;
OS Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=158878;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mu50 / ATCC 700699;
RX PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA Hiramatsu K.;
RT "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL Lancet 357:1225-1240(2001).
CC -!- FUNCTION: Mnh complex is a Na(+)/H(+) antiporter involved in Na(+)
CC excretion. {ECO:0000250}.
CC -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC subunits: mnhA1, mnhB1, mnhC1, mnhD1, mnhE1, mnhF1 and mnhG1.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E
CC family. {ECO:0000305}.
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DR EMBL; BA000017; BAB57110.1; -; Genomic_DNA.
DR RefSeq; WP_000290674.1; NC_002758.2.
DR AlphaFoldDB; P60688; -.
DR SMR; P60688; -.
DR PaxDb; P60688; -.
DR EnsemblBacteria; BAB57110; BAB57110; SAV0948.
DR KEGG; sav:SAV0948; -.
DR HOGENOM; CLU_086615_3_2_9; -.
DR OMA; HAMDIED; -.
DR PhylomeDB; P60688; -.
DR BioCyc; SAUR158878:SAV_RS05155-MON; -.
DR Proteomes; UP000002481; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR InterPro; IPR004847; Antiport_suE1.
DR InterPro; IPR002758; Cation_antiport_E.
DR PANTHER; PTHR34584; PTHR34584; 1.
DR Pfam; PF01899; MNHE; 1.
DR PIRSF; PIRSF019239; MrpE; 1.
DR TIGRFAMs; TIGR00942; 2a6301s05; 1.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Hydrogen ion transport; Ion transport; Membrane;
KW Sodium; Sodium transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..159
FT /note="Na(+)/H(+) antiporter subunit E1"
FT /id="PRO_0000217087"
FT TRANSMEM 5..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..69
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..122
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 159 AA; 18319 MW; 95C11B67E678D3B7 CRC64;
MAVQLVLNFI IAVFWLFVTN SYTTNNFVLG FIFGLVLVYL LHRVLPGRFY VITLYRIIKL
VIIFLIELIK ANFDVLKIII KPSIKNEPGF FVYHTDLKKD WQIVLLSNLI TLTPGTVVLG
VSDDRTKIYI HAIDFSTKEQ EVESIKTSLE KIVREVGEI