MNHE2_STAA1
ID MNHE2_STAA1 Reviewed; 160 AA.
AC A7WZ80;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 1.
DT 25-MAY-2022, entry version 67.
DE RecName: Full=Putative antiporter subunit mnhE2;
DE AltName: Full=Mrp complex subunit E2;
DE AltName: Full=Putative NADH-ubiquinone oxidoreductase subunit mnhE2;
GN Name=mnhE2; Synonyms=mrpE2; OrderedLocusNames=SAHV_0623;
OS Staphylococcus aureus (strain Mu3 / ATCC 700698).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=418127;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Mu3 / ATCC 700698;
RX PubMed=17954695; DOI=10.1128/aac.00534-07;
RA Neoh H.-M., Cui L., Yuzawa H., Takeuchi F., Matsuo M., Hiramatsu K.;
RT "Mutated response regulator graR is responsible for phenotypic conversion
RT of Staphylococcus aureus from heterogeneous vancomycin-intermediate
RT resistance to vancomycin-intermediate resistance.";
RL Antimicrob. Agents Chemother. 52:45-53(2008).
CC -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC subunits: mnhA2, mnhB2, mnhC2, mnhD2, mnhE2, mnhF2 and mnhG2.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E
CC family. {ECO:0000305}.
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DR EMBL; AP009324; BAF77506.1; -; Genomic_DNA.
DR RefSeq; WP_001071971.1; NC_009782.1.
DR AlphaFoldDB; A7WZ80; -.
DR SMR; A7WZ80; -.
DR KEGG; saw:SAHV_0623; -.
DR HOGENOM; CLU_086615_3_2_9; -.
DR OMA; YSRRIPR; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR002758; Cation_antiport_E.
DR PANTHER; PTHR34584; PTHR34584; 1.
DR Pfam; PF01899; MNHE; 1.
DR PIRSF; PIRSF019239; MrpE; 1.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Ion transport; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..160
FT /note="Putative antiporter subunit mnhE2"
FT /id="PRO_0000372216"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 160 AA; 18835 MW; 9E8891750A665B56 CRC64;
MNQIVLNIII AFLWVLFQDE DHFKFSTFFS GYLIGLIVIY ILHRFFSDDF YVRKIWVAIK
FLGVYLYQLI TSSISTINYI LFKTKDMNPG LLSYETRLTS DWAITFLTIL IIITPGSTVI
RISQDSKKFF IHSIDVSEKE KDSLLRSIKH YEDLILEVSR