ID   MNHE2_STAA8             Reviewed;         160 AA.
AC   Q2G210;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Putative antiporter subunit mnhE2;
DE   AltName: Full=Mrp complex subunit E2;
DE   AltName: Full=Putative NADH-ubiquinone oxidoreductase subunit mnhE2;
GN   Name=mnhE2; Synonyms=mrpE2; OrderedLocusNames=SAOUHSC_00629;
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
CC   -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC       subunits: mnhA2, mnhB2, mnhC2, mnhD2, mnhE2, mnhF2 and mnhG2.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E
CC       family. {ECO:0000305}.
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DR   EMBL; CP000253; ABD29766.1; -; Genomic_DNA.
DR   RefSeq; WP_001071973.1; NZ_LS483365.1.
DR   RefSeq; YP_499191.1; NC_007795.1.
DR   AlphaFoldDB; Q2G210; -.
DR   SMR; Q2G210; -.
DR   STRING; 1280.SAXN108_0693; -.
DR   EnsemblBacteria; ABD29766; ABD29766; SAOUHSC_00629.
DR   GeneID; 3920039; -.
DR   KEGG; sao:SAOUHSC_00629; -.
DR   PATRIC; fig|93061.5.peg.565; -.
DR   eggNOG; COG1863; Bacteria.
DR   HOGENOM; CLU_086615_3_2_9; -.
DR   OMA; YSRRIPR; -.
DR   PRO; PR:Q2G210; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR002758; Cation_antiport_E.
DR   PANTHER; PTHR34584; PTHR34584; 1.
DR   Pfam; PF01899; MNHE; 1.
DR   PIRSF; PIRSF019239; MrpE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Ion transport; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..160
FT                   /note="Putative antiporter subunit mnhE2"
FT                   /id="PRO_0000372220"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   160 AA;  18851 MW;  9E9A837518745B56 CRC64;
     MNQIVLNIII AFLWVLFQDE DHFKFSTFFS GYLIGLIVIY ILHRFFSDDF YVRKIWVAIK
     FLGVYLYQLI TSSISTINYI LFKTKDMNPG LLSYETRLTS DWSITFLTIL IIITPGSTVI
     RISQDSKKFF IHSIDVSEKE KDSLLRSIKH YEDLILEVSR