ID   6PGL_DICDI              Reviewed;         236 AA.
AC   Q54CJ3;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Probable 6-phosphogluconolactonase;
DE            Short=6PGL;
DE            EC=3.1.1.31;
GN   Name=pgl; Synonyms=pgls; ORFNames=DDB_G0292898;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate
CC         + H(+); Xref=Rhea:RHEA:12556, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57955, ChEBI:CHEBI:58759; EC=3.1.1.31;
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step
CC       2/3.
CC   -!- SIMILARITY: Belongs to the glucosamine/galactosamine-6-phosphate
CC       isomerase family. 6-phosphogluconolactonase subfamily. {ECO:0000305}.
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DR   EMBL; AAFI02000197; EAL60998.1; -; Genomic_DNA.
DR   RefSeq; XP_629423.1; XM_629421.1.
DR   AlphaFoldDB; Q54CJ3; -.
DR   SMR; Q54CJ3; -.
DR   STRING; 44689.DDB0231287; -.
DR   PaxDb; Q54CJ3; -.
DR   EnsemblProtists; EAL60998; EAL60998; DDB_G0292898.
DR   GeneID; 8628942; -.
DR   KEGG; ddi:DDB_G0292898; -.
DR   dictyBase; DDB_G0292898; pgl.
DR   eggNOG; KOG3147; Eukaryota.
DR   HOGENOM; CLU_053947_2_0_1; -.
DR   InParanoid; Q54CJ3; -.
DR   OMA; NDERWVD; -.
DR   PhylomeDB; Q54CJ3; -.
DR   Reactome; R-DDI-71336; Pentose phosphate pathway.
DR   UniPathway; UPA00115; UER00409.
DR   PRO; PR:Q54CJ3; -.
DR   Proteomes; UP000002195; Chromosome 6.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0017057; F:6-phosphogluconolactonase activity; IBA:GO_Central.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0009051; P:pentose-phosphate shunt, oxidative branch; IBA:GO_Central.
DR   CDD; cd01400; 6PGL; 1.
DR   InterPro; IPR005900; 6-phosphogluconolactonase_DevB.
DR   InterPro; IPR006148; Glc/Gal-6P_isomerase.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR039104; PGLS.
DR   PANTHER; PTHR11054; PTHR11054; 1.
DR   Pfam; PF01182; Glucosamine_iso; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
DR   TIGRFAMs; TIGR01198; pgl; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Reference proteome.
FT   CHAIN           1..236
FT                   /note="Probable 6-phosphogluconolactonase"
FT                   /id="PRO_0000327748"
SQ   SEQUENCE   236 AA;  26824 MW;  AC9493CB9D2A787A CRC64;
     MTSKLINFIT IEKERFEDEC VKFIKNVITD SINSRNIATI GLSGGSTPKP IYEMLGNDSS
     IDWTKVYFFA VDERYIDKSS KDSIYDLISK SVFKNRENLL VDHFITPNTS LPLKECIETY
     SNDLKKLIEK SNGSPDLVTL GMGEDGHIAS IFPNSPKSPL DETDLVYHTT TERFAIFDRI
     TTNINFLASS KNKVFFMSGS SKKKVWDEME SSQINVSRWP AHKIISSGNT NVFYRE