MNHE2_STAAR
ID MNHE2_STAAR Reviewed; 160 AA.
AC Q6GJ43;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Putative antiporter subunit mnhE2;
DE AltName: Full=Mrp complex subunit E2;
DE AltName: Full=Putative NADH-ubiquinone oxidoreductase subunit mnhE2;
GN Name=mnhE2; Synonyms=mrpE2; OrderedLocusNames=SAR0634;
OS Staphylococcus aureus (strain MRSA252).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=282458;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MRSA252;
RX PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT for the rapid evolution of virulence and drug resistance.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC subunits: mnhA2, mnhB2, mnhC2, mnhD2, mnhE2, mnhF2 and mnhG2.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E
CC family. {ECO:0000305}.
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DR EMBL; BX571856; CAG39652.1; -; Genomic_DNA.
DR RefSeq; WP_001071971.1; NC_002952.2.
DR AlphaFoldDB; Q6GJ43; -.
DR SMR; Q6GJ43; -.
DR KEGG; sar:SAR0634; -.
DR HOGENOM; CLU_086615_3_2_9; -.
DR OMA; YSRRIPR; -.
DR OrthoDB; 1987527at2; -.
DR Proteomes; UP000000596; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR InterPro; IPR002758; Cation_antiport_E.
DR PANTHER; PTHR34584; PTHR34584; 1.
DR Pfam; PF01899; MNHE; 1.
DR PIRSF; PIRSF019239; MrpE; 1.
PE 3: Inferred from homology;
KW Antiport; Cell membrane; Ion transport; Membrane; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..160
FT /note="Putative antiporter subunit mnhE2"
FT /id="PRO_0000372214"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 160 AA; 18835 MW; 9E8891750A665B56 CRC64;
MNQIVLNIII AFLWVLFQDE DHFKFSTFFS GYLIGLIVIY ILHRFFSDDF YVRKIWVAIK
FLGVYLYQLI TSSISTINYI LFKTKDMNPG LLSYETRLTS DWAITFLTIL IIITPGSTVI
RISQDSKKFF IHSIDVSEKE KDSLLRSIKH YEDLILEVSR