ID   MNHE2_STAAT             Reviewed;         160 AA.
AC   A8Z148;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Putative antiporter subunit mnhE2;
DE   AltName: Full=Mrp complex subunit E2;
DE   AltName: Full=Putative NADH-ubiquinone oxidoreductase subunit mnhE2;
GN   Name=mnhE2; Synonyms=mrpE2; OrderedLocusNames=USA300HOU_0647;
OS   Staphylococcus aureus (strain USA300 / TCH1516).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=451516;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USA300 / TCH1516;
RX   PubMed=17986343; DOI=10.1186/1471-2180-7-99;
RA   Highlander S.K., Hulten K.G., Qin X., Jiang H., Yerrapragada S.,
RA   Mason E.O. Jr., Shang Y., Williams T.M., Fortunov R.M., Liu Y., Igboeli O.,
RA   Petrosino J., Tirumalai M., Uzman A., Fox G.E., Cardenas A.M., Muzny D.M.,
RA   Hemphill L., Ding Y., Dugan S., Blyth P.R., Buhay C.J., Dinh H.H.,
RA   Hawes A.C., Holder M., Kovar C.L., Lee S.L., Liu W., Nazareth L.V.,
RA   Wang Q., Zhou J., Kaplan S.L., Weinstock G.M.;
RT   "Subtle genetic changes enhance virulence of methicillin resistant and
RT   sensitive Staphylococcus aureus.";
RL   BMC Microbiol. 7:99-99(2007).
CC   -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC       subunits: mnhA2, mnhB2, mnhC2, mnhD2, mnhE2, mnhF2 and mnhG2.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E
CC       family. {ECO:0000305}.
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DR   EMBL; CP000730; ABX28669.1; -; Genomic_DNA.
DR   RefSeq; WP_001071973.1; NC_010079.1.
DR   AlphaFoldDB; A8Z148; -.
DR   SMR; A8Z148; -.
DR   KEGG; sax:USA300HOU_0647; -.
DR   HOGENOM; CLU_086615_3_2_9; -.
DR   OMA; YSRRIPR; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR002758; Cation_antiport_E.
DR   PANTHER; PTHR34584; PTHR34584; 1.
DR   Pfam; PF01899; MNHE; 1.
DR   PIRSF; PIRSF019239; MrpE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Ion transport; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..160
FT                   /note="Putative antiporter subunit mnhE2"
FT                   /id="PRO_0000372222"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   160 AA;  18851 MW;  9E9A837518745B56 CRC64;
     MNQIVLNIII AFLWVLFQDE DHFKFSTFFS GYLIGLIVIY ILHRFFSDDF YVRKIWVAIK
     FLGVYLYQLI TSSISTINYI LFKTKDMNPG LLSYETRLTS DWSITFLTIL IIITPGSTVI
     RISQDSKKFF IHSIDVSEKE KDSLLRSIKH YEDLILEVSR