ID   MNHE2_STAAW             Reviewed;         160 AA.
AC   Q8NXT0;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Putative antiporter subunit mnhE2;
DE   AltName: Full=Mrp complex subunit E2;
DE   AltName: Full=Putative NADH-ubiquinone oxidoreductase subunit mnhE2;
GN   Name=mnhE2; Synonyms=mrpE2; OrderedLocusNames=MW0589;
OS   Staphylococcus aureus (strain MW2).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=196620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MW2;
RX   PubMed=12044378; DOI=10.1016/s0140-6736(02)08713-5;
RA   Baba T., Takeuchi F., Kuroda M., Yuzawa H., Aoki K., Oguchi A., Nagai Y.,
RA   Iwama N., Asano K., Naimi T., Kuroda H., Cui L., Yamamoto K., Hiramatsu K.;
RT   "Genome and virulence determinants of high virulence community-acquired
RT   MRSA.";
RL   Lancet 359:1819-1827(2002).
CC   -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC       subunits: mnhA2, mnhB2, mnhC2, mnhD2, mnhE2, mnhF2 and mnhG2.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E
CC       family. {ECO:0000305}.
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DR   EMBL; BA000033; BAB94454.1; -; Genomic_DNA.
DR   RefSeq; WP_001071973.1; NC_003923.1.
DR   AlphaFoldDB; Q8NXT0; -.
DR   SMR; Q8NXT0; -.
DR   EnsemblBacteria; BAB94454; BAB94454; BAB94454.
DR   KEGG; sam:MW0589; -.
DR   HOGENOM; CLU_086615_3_2_9; -.
DR   OMA; YSRRIPR; -.
DR   Proteomes; UP000000418; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0008324; F:cation transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR002758; Cation_antiport_E.
DR   PANTHER; PTHR34584; PTHR34584; 1.
DR   Pfam; PF01899; MNHE; 1.
DR   PIRSF; PIRSF019239; MrpE; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Ion transport; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..160
FT                   /note="Putative antiporter subunit mnhE2"
FT                   /id="PRO_0000372218"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   160 AA;  18851 MW;  9E9A837518745B56 CRC64;
     MNQIVLNIII AFLWVLFQDE DHFKFSTFFS GYLIGLIVIY ILHRFFSDDF YVRKIWVAIK
     FLGVYLYQLI TSSISTINYI LFKTKDMNPG LLSYETRLTS DWSITFLTIL IIITPGSTVI
     RISQDSKKFF IHSIDVSEKE KDSLLRSIKH YEDLILEVSR