ID   MNHF1_STAEQ             Reviewed;          97 AA.
AC   Q5HQL5;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Na(+)/H(+) antiporter subunit F1;
DE   AltName: Full=Mnh complex subunit F1;
GN   Name=mnhF1; OrderedLocusNames=SERP0533;
OS   Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35984 / RP62A;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Mnh complex is a Na(+)/H(+) antiporter involved in Na(+)
CC       excretion. {ECO:0000250}.
CC   -!- SUBUNIT: May form a heterooligomeric complex that consists of seven
CC       subunits: mnhA1, mnhB1, mnhC1, mnhD1, mnhE1, mnhF1 and mnhG1.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the CPA3 antiporters (TC 2.A.63) subunit F
CC       family. {ECO:0000305}.
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DR   EMBL; CP000029; AAW53929.1; -; Genomic_DNA.
DR   RefSeq; WP_001831940.1; NC_002976.3.
DR   AlphaFoldDB; Q5HQL5; -.
DR   SMR; Q5HQL5; -.
DR   STRING; 176279.SERP0533; -.
DR   EnsemblBacteria; AAW53929; AAW53929; SERP0533.
DR   GeneID; 50019212; -.
DR   KEGG; ser:SERP0533; -.
DR   eggNOG; COG2212; Bacteria.
DR   HOGENOM; CLU_125825_1_3_9; -.
DR   OMA; VIAFARY; -.
DR   OrthoDB; 2083248at2; -.
DR   Proteomes; UP000000531; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0015075; F:ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   InterPro; IPR007208; MrpF/PhaF-like.
DR   PANTHER; PTHR34702; PTHR34702; 1.
DR   Pfam; PF04066; MrpF_PhaF; 1.
DR   PIRSF; PIRSF028784; MrpF; 1.
PE   3: Inferred from homology;
KW   Antiport; Cell membrane; Hydrogen ion transport; Ion transport; Membrane;
KW   Reference proteome; Sodium; Sodium transport; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..97
FT                   /note="Na(+)/H(+) antiporter subunit F1"
FT                   /id="PRO_0000372160"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        60..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   97 AA;  10669 MW;  2BDA770093864C26 CRC64;
     MPFKIFIITA LIIVVLSMLA MLIRVILGPS LADRVVALDA IGLQLMAVIA LFSILLNIKY
     MLVVILMVGI LAFLGTAVFS KFMDEGKVIK HDSNDRH