ARLY_TREPR
ID ARLY_TREPR Reviewed; 452 AA.
AC Q8KTQ9;
DT 23-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 25-MAY-2022, entry version 79.
DE RecName: Full=Argininosuccinate lyase {ECO:0000255|HAMAP-Rule:MF_00006};
DE Short=ASAL {ECO:0000255|HAMAP-Rule:MF_00006};
DE EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE AltName: Full=Arginosuccinase {ECO:0000255|HAMAP-Rule:MF_00006};
GN Name=argH {ECO:0000255|HAMAP-Rule:MF_00006};
OS Tremblaya princeps.
OC Bacteria; Proteobacteria; Betaproteobacteria; Candidatus Tremblaya.
OX NCBI_TaxID=189385;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12088995; DOI=10.1128/aem.68.7.3198-3205.2002;
RA Baumann L., Thao M.L., Hess J.M., Johnson M.W., Baumann P.;
RT "The genetic properties of the primary endosymbionts of mealybugs differ
RT from those of other endosymbionts of plant sap-sucking insects.";
RL Appl. Environ. Microbiol. 68:3198-3205(2002).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence={ECO:0000255|HAMAP-
CC Rule:MF_00006};
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000255|HAMAP-
CC Rule:MF_00006}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
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DR EMBL; AF481102; AAM75989.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8KTQ9; -.
DR SMR; Q8KTQ9; -.
DR UniPathway; UPA00068; UER00114.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR CDD; cd01359; Argininosuccinate_lyase; 1.
DR Gene3D; 1.10.275.10; -; 1.
DR HAMAP; MF_00006; Arg_succ_lyase; 1.
DR InterPro; IPR029419; Arg_succ_lyase_C.
DR InterPro; IPR009049; Argininosuccinate_lyase.
DR InterPro; IPR024083; Fumarase/histidase_N.
DR InterPro; IPR020557; Fumarate_lyase_CS.
DR InterPro; IPR000362; Fumarate_lyase_fam.
DR InterPro; IPR022761; Fumarate_lyase_N.
DR InterPro; IPR008948; L-Aspartase-like.
DR PANTHER; PTHR43814; PTHR43814; 1.
DR Pfam; PF14698; ASL_C2; 1.
DR Pfam; PF00206; Lyase_1; 1.
DR PRINTS; PR00149; FUMRATELYASE.
DR SUPFAM; SSF48557; SSF48557; 1.
DR TIGRFAMs; TIGR00838; argH; 1.
DR PROSITE; PS00163; FUMARATE_LYASES; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; Lyase.
FT CHAIN 1..452
FT /note="Argininosuccinate lyase"
FT /id="PRO_0000137755"
FT REGION 431..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 452 AA; 48814 MW; 4364C3EBA945DE00 CRC64;
MWSGRFSSPV CAPVQSFTAS VGFDRAMCHC DAAVLAAHCR SLYLRRVMSI ADLADVERGL
SEVAMGARAG AISWRPELED VHRNVEHVLT ELVGKAGRMA HTGKSRNDQV STTARVWLRH
MAGAAICRVE ELERALAARS RACLNTMMPG LTHMQVAQPV TAAHYLTAYR CMLSRDRSRL
VRCTRGACVL TLGSGALAGT NHGGDRYTTA DMLGLHCVSP NSLDAVSDRD FVMEYALCCA
VLMVHMSRLA EDMIAWSSSI VGFAVLGDAL CTGSSIMPQK KNPDILELVR AKAAVLIGGA
MGIMAVMKAQ GLAYNRDNQE DKAVLLGASR AVTRSLSVMA LAVRSLRLNK SRLRRRLESS
FAIATDLADS LVWHGMTFRD SHEAVARAVG VAIRAGHAGL RALPLCSRGV VPPLLAARLA
RIAQPDARVS AFRKDSTGST SPKWSFRAMR RA