MNL1_CANAL
ID MNL1_CANAL Reviewed; 905 AA.
AC Q59RR3; A0A1D8PTH7;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Transcriptional regulator MNL1;
DE AltName: Full=MSN2- and MSN4-like protein 1;
GN Name=MNL1; Synonyms=MSN2; OrderedLocusNames=CAALFM_CR07450CA;
GN ORFNames=CaO19.13540, CaO19.6121;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP FUNCTION.
RX PubMed=15470239; DOI=10.1128/ec.3.5.1111-1123.2004;
RA Nicholls S., Straffon M., Enjalbert B., Nantel A., Macaskill S.,
RA Whiteway M., Brown A.J.;
RT "Msn2- and Msn4-like transcription factors play no obvious roles in the
RT stress responses of the fungal pathogen Candida albicans.";
RL Eukaryot. Cell 3:1111-1123(2004).
RN [5]
RP FUNCTION.
RX PubMed=18653474; DOI=10.1091/mbc.e07-09-0946;
RA Ramsdale M., Selway L., Stead D., Walker J., Yin Z., Nicholls S.M.,
RA Crowe J., Sheils E.M., Brown A.J.;
RT "MNL1 regulates weak acid-induced stress responses of the fungal pathogen
RT Candida albicans.";
RL Mol. Biol. Cell 19:4393-4403(2008).
CC -!- FUNCTION: Transcription factor that activates stress response genes via
CC SLE (STRE-like) elements. Required for adaptation to weak acid stress
CC such as acetic acid stress, but seems not involved in the response to
CC heat, osmotic, ethanol, nutrient, oxidative, or heavy-metal stress.
CC Activates a subset of the genes that are repressed by NRG1.
CC {ECO:0000269|PubMed:15470239, ECO:0000269|PubMed:18653474}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
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DR EMBL; CP017630; AOW31438.1; -; Genomic_DNA.
DR RefSeq; XP_712328.2; XM_707235.2.
DR AlphaFoldDB; Q59RR3; -.
DR STRING; 237561.Q59RR3; -.
DR PRIDE; Q59RR3; -.
DR GeneID; 3646050; -.
DR KEGG; cal:CAALFM_CR07450CA; -.
DR CGD; CAL0000183599; MNL1.
DR VEuPathDB; FungiDB:CR_07450C_A; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_320537_0_0_1; -.
DR InParanoid; Q59RR3; -.
DR OrthoDB; 855900at2759; -.
DR PRO; PR:Q59RR3; -.
DR Proteomes; UP000000559; Chromosome R.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043619; P:regulation of transcription from RNA polymerase II promoter in response to oxidative stress; IBA:GO_Central.
DR GO; GO:0042594; P:response to starvation; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 1.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..905
FT /note="Transcriptional regulator MNL1"
FT /id="PRO_0000426086"
FT ZN_FING 832..855
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 861..883
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 383..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 434..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 525..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 584..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 685..733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 885..905
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 400..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..539
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 646..671
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..733
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 905 AA; 100509 MW; C9E1C9EA2EF8A1AE CRC64;
MDSHNNIDQS VSELLSDPAS VQQSYNSQLR GPEFDQQRQI RNQVSPFNKM TDTIDNDNIP
LSSDYDKLYQ QFSIPSQQQY ENNSDNVYKT NNDLAALASP LNMDLDLAPS DQQQQPQQSQ
QQFLNDFSNL QPHLNNSQEQ VQLNGLTSNI LSNPQITVNM PGAYHQNYNC DQMEIDDSPP
FTIESDLYFE QQTDNNSIVT SNRVHNQPDV ESMFNNQLSV PSLQRTELSP QQHETNVTTG
RPQESAFGSF DNNSRVSSFA NVNNAGTNLF VNGKDLYFDD ESHHRTGRLR NGSIDSYYAA
NVINHQLHLQ QQTQAQAQAH QQQQQQSQQQ HSPQDLASHT SLPSKSIYNE LSPLTTTTSR
ASSIQSGQPS FFSAQQYFSR NSMDQVPSSL HRPSFDLYNH RPSIDSQHSQ QSQQRNARYT
SFTSSISNIL PFMSEKNTNH NNRSPPTPPT STSSPQNLLS SNQSRHLIRS IFKTNPTPIV
SDAGNSNGNI VNGGSGTIDA ENLPDAPYAS GTINDSEFLI LSSPTKEEPE DELMQPKKVK
KPKRSLFTRF KTPVKQEQPD SEMAVSAPVD ELKPDETVID MVGNISSHHS SGTPSITTGA
GGNTLEHSIS ESSFQEPDYA ALFENVGKRK NKSYRKPKGK TKEEEQQQQQ LPLSSGTAGG
TSSNNSTGTV EKTLFFNKTK IKKEPASERS SLLDNASAGN ASASSSEASS IQNAIGSDDH
NGPPLTSAPT SSTLANASKR ILSSKLISKK KSTSKLKEYT AAELEDMCTV SSLETPVATM
ISKGIEVEVD LASLDLPPDT KIFPTSIINN KNRTRGRKEN KEADLSDTSK IYLCNLCQRR
FKRHEHLKRH FRSLHTFEKP YNCDICHKKF SRSDNLNQHL KIHKQEDEKD CADAETGVGM
DDASG
