MNM1_ARATH
ID MNM1_ARATH Reviewed; 286 AA.
AC Q8L7T9; Q2V2Y5; Q9FFT7;
DT 23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Protein METABOLIC NETWORK MODULATOR 1 {ECO:0000303|PubMed:25202318};
GN Name=MNM1 {ECO:0000303|PubMed:25202318};
GN OrderedLocusNames=At5g54930 {ECO:0000312|Araport:AT5G54930};
GN ORFNames=MBG8.20 {ECO:0000312|EMBL:BAB08772.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9330910; DOI=10.1093/dnares/4.3.215;
RA Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M.,
RA Miyajima N., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence
RT features of the 1.6 Mb regions covered by twenty physically assigned P1
RT clones.";
RL DNA Res. 4:215-230(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia; TISSUE=Flower, and Silique;
RX PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA Shinozaki K.;
RT "Analysis of multiple occurrences of alternative splicing events in
RT Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL DNA Res. 16:155-164(2009).
RN [5]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC STRAIN=cv. Columbia;
RX PubMed=25202318; DOI=10.3389/fpls.2014.00415;
RA Li B., Kliebenstein D.J.;
RT "The AT-hook motif-encoding gene METABOLIC NETWORK MODULATOR 1 underlies
RT natural variation in Arabidopsis primary metabolism.";
RL Front. Plant Sci. 5:415-415(2014).
CC -!- FUNCTION: Lineage-specific modulator of primary metabolism
CC (PubMed:25202318). Influences flowering time (PubMed:25202318).
CC {ECO:0000269|PubMed:25202318}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8L7T9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8L7T9-2; Sequence=VSP_061448;
CC -!- TISSUE SPECIFICITY: Mailny observed in young seedlings and in emerging
CC leaves. {ECO:0000269|PubMed:25202318}.
CC -!- DEVELOPMENTAL STAGE: In young seedlings, mostly expressed in the newly
CC emerging leaves and in the vasculature of roots and cotyledons
CC (PubMed:25202318). Later fades out of the vasculature but remains at
CC high levels in emerging leaves (PubMed:25202318). Present at the base
CC of maturing leaves but excluded from the vasculature (PubMed:25202318).
CC In short days conditions, accumulates in newly emerging leaves, but as
CC these leaves mature, gradually lost in the lamina until being confined
CC to the margin (PubMed:25202318). Disapears in mature leaves
CC (PubMed:25202318). {ECO:0000269|PubMed:25202318}.
CC -!- DISRUPTION PHENOTYPE: Slightly earlier flowering time under both short
CC and long-day conditions (PubMed:25202318). Altered metabolites profile
CC (PubMed:25202318). {ECO:0000269|PubMed:25202318}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB08772.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB005232; BAB08772.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED96558.1; -; Genomic_DNA.
DR EMBL; CP002688; AED96559.1; -; Genomic_DNA.
DR EMBL; AY127021; AAM83245.1; -; mRNA.
DR EMBL; BT004509; AAO42755.1; -; mRNA.
DR EMBL; AK317764; BAH20420.1; -; mRNA.
DR RefSeq; NP_568817.1; NM_124875.5.
DR AlphaFoldDB; Q8L7T9; -.
DR STRING; 3702.AT5G54930.1; -.
DR PaxDb; Q8L7T9; -.
DR PRIDE; Q8L7T9; -.
DR ProteomicsDB; 187052; -.
DR ProteomicsDB; 187320; -.
DR EnsemblPlants; AT5G54930.1; AT5G54930.1; AT5G54930. [Q8L7T9-1]
DR EnsemblPlants; AT5G54930.2; AT5G54930.2; AT5G54930. [Q8L7T9-2]
DR GeneID; 835584; -.
DR Gramene; AT5G54930.1; AT5G54930.1; AT5G54930. [Q8L7T9-1]
DR Gramene; AT5G54930.2; AT5G54930.2; AT5G54930. [Q8L7T9-2]
DR Araport; AT5G54930; -.
DR TAIR; locus:2160240; AT5G54930.
DR eggNOG; KOG1347; Eukaryota.
DR HOGENOM; CLU_1055042_0_0_1; -.
DR InParanoid; Q8L7T9; -.
DR OMA; SNSKPFE; -.
DR OrthoDB; 1083397at2759; -.
DR PhylomeDB; Q8L7T9; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8L7T9; baseline and differential.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0044238; P:primary metabolic process; IMP:UniProtKB.
DR GO; GO:2000028; P:regulation of photoperiodism, flowering; IMP:UniProtKB.
DR InterPro; IPR045881; MNM1-like.
DR PANTHER; PTHR34682; PTHR34682; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..286
FT /note="Protein METABOLIC NETWORK MODULATOR 1"
FT /id="PRO_0000455089"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 123..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..58
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 271..273
FT /note="Missing (in isoform 2)"
FT /id="VSP_061448"
SQ SEQUENCE 286 AA; 31545 MW; 8BA5610A78292303 CRC64;
MEKESHEENN HTISGDLTAK RKRGRPRKQL KLESNEHSLG HSPSFSRSQQ QSRQRNDDEA
MVGQPISGVI EATFEAGFLL SVKVGNSDSM LRGVVFKPGH CDPVSVDNDV APDVPMIRRN
SDVMHHDGSA KRGRKSRFRE KRGSGVRSRA LVPVPIQPAH PTIPNNLIVP VVLQPAHLEN
GGERVPIDHS PMQTETGSQA SGASNGKPFE TLLTQVMNKG QVQHTTQSVE PESDEQALSI
EPLQAIHPIH PVHMLKPMPS YGRGKMTELL QAVQENVRET HFSQGH
