ID   ARLY_VIBC3              Reviewed;         458 AA.
AC   A5F4Z3; C3LXN9;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Argininosuccinate lyase {ECO:0000255|HAMAP-Rule:MF_00006};
DE            Short=ASAL {ECO:0000255|HAMAP-Rule:MF_00006};
DE            EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE   AltName: Full=Arginosuccinase {ECO:0000255|HAMAP-Rule:MF_00006};
GN   Name=argH {ECO:0000255|HAMAP-Rule:MF_00006};
GN   OrderedLocusNames=VC0395_A2217, VC395_2754;
OS   Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 /
OS   O395).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=345073;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RA   Heidelberg J.;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39541 / Classical Ogawa 395 / O395;
RX   PubMed=19115014; DOI=10.1371/journal.pone.0004053;
RA   Feng L., Reeves P.R., Lan R., Ren Y., Gao C., Zhou Z., Ren Y., Cheng J.,
RA   Wang W., Wang J., Qian W., Li D., Wang L.;
RT   "A recalibrated molecular clock and independent origins for the cholera
RT   pandemic clones.";
RL   PLoS ONE 3:E4053-E4053(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC         Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC         ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00006};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC       from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000255|HAMAP-
CC       Rule:MF_00006}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC   -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
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DR   EMBL; CP000627; ABQ19766.1; -; Genomic_DNA.
DR   EMBL; CP001235; ACP10739.1; -; Genomic_DNA.
DR   RefSeq; WP_001240133.1; NZ_JAACZH010000007.1.
DR   AlphaFoldDB; A5F4Z3; -.
DR   SMR; A5F4Z3; -.
DR   STRING; 345073.VC395_2754; -.
DR   EnsemblBacteria; ABQ19766; ABQ19766; VC0395_A2217.
DR   KEGG; vco:VC0395_A2217; -.
DR   KEGG; vcr:VC395_2754; -.
DR   PATRIC; fig|345073.21.peg.2653; -.
DR   eggNOG; COG0165; Bacteria.
DR   HOGENOM; CLU_027272_2_3_6; -.
DR   OMA; KKNPDVF; -.
DR   UniPathway; UPA00068; UER00114.
DR   Proteomes; UP000000249; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR   CDD; cd01359; Argininosuccinate_lyase; 1.
DR   Gene3D; 1.10.275.10; -; 1.
DR   HAMAP; MF_00006; Arg_succ_lyase; 1.
DR   InterPro; IPR029419; Arg_succ_lyase_C.
DR   InterPro; IPR009049; Argininosuccinate_lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR020557; Fumarate_lyase_CS.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   PANTHER; PTHR43814; PTHR43814; 1.
DR   Pfam; PF14698; ASL_C2; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; SSF48557; 1.
DR   TIGRFAMs; TIGR00838; argH; 1.
DR   PROSITE; PS00163; FUMARATE_LYASES; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; Lyase.
FT   CHAIN           1..458
FT                   /note="Argininosuccinate lyase"
FT                   /id="PRO_1000070923"
SQ   SEQUENCE   458 AA;  50331 MW;  F1BA176B23D61B9C CRC64;
     MALWGGRFTQ AADSRFKSFN DSLRFDYRLA EQDIVGSIAW SKALVSVNVL SVQEQQQLEQ
     ALNHLLQSVQ QDPEQILASD AEDIHSWVEQ KLIEQVGDLG KKLHTGRSRN DQVATDLKLW
     CRDQGVHLLL ALKTLQQQLV AVAAEHQSTV LPGYTHLQRA QPVTFTHWCL AYLEMFERDE
     SRLTDALARL NTSPLGSGAL AGTAYAIDRE VLAADLGFTR ATRNSLDAVS DRDHVMELMS
     VASISMLHLS RLAEDMIFYT TGEAGFIELA DTVTSGSSLM PQKKNPDALE LIRGKTGRVY
     GALAGMMMTV KALPLAYNKD MQEDKEGLFD ALDTWFDCLQ MAGLCFDGIK VNAARTLEAA
     KQGYSNATEL ADYLVAKGIP FREAHHIVGV AVVAAIGKGV ALEELCLAEL QQFSPLIEQD
     VYPILTIESC LEKRCALGGV SPKQVAHALQ QAQARVKS