ID   ARLY_ZYMMO              Reviewed;         468 AA.
AC   Q9Z660; Q5NLL6;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 2.
DT   25-MAY-2022, entry version 126.
DE   RecName: Full=Argininosuccinate lyase {ECO:0000255|HAMAP-Rule:MF_00006};
DE            Short=ASAL {ECO:0000255|HAMAP-Rule:MF_00006};
DE            EC=4.3.2.1 {ECO:0000255|HAMAP-Rule:MF_00006};
DE   AltName: Full=Arginosuccinase {ECO:0000255|HAMAP-Rule:MF_00006};
GN   Name=argH {ECO:0000255|HAMAP-Rule:MF_00006}; OrderedLocusNames=ZMO1770;
OS   Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Zymomonadaceae; Zymomonas.
OX   NCBI_TaxID=264203;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 31821 / ZM4 / CP4;
RA   Um H.W., Kang H.S.;
RL   Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 31821 / ZM4 / CP4;
RX   PubMed=15592456; DOI=10.1038/nbt1045;
RA   Seo J.-S., Chong H., Park H.S., Yoon K.-O., Jung C., Kim J.J., Hong J.H.,
RA   Kim H., Kim J.-H., Kil J.-I., Park C.J., Oh H.-M., Lee J.-S., Jin S.-J.,
RA   Um H.-W., Lee H.-J., Oh S.-J., Kim J.Y., Kang H.L., Lee S.Y., Lee K.J.,
RA   Kang H.S.;
RT   "The genome sequence of the ethanologenic bacterium Zymomonas mobilis
RT   ZM4.";
RL   Nat. Biotechnol. 23:63-68(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC         Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC         ChEBI:CHEBI:57472; EC=4.3.2.1; Evidence={ECO:0000255|HAMAP-
CC         Rule:MF_00006};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine
CC       from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000255|HAMAP-
CC       Rule:MF_00006}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00006}.
CC   -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_00006}.
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DR   EMBL; AF102543; AAD19417.1; -; Genomic_DNA.
DR   EMBL; AE008692; AAV90394.1; -; Genomic_DNA.
DR   RefSeq; WP_011241510.1; NC_006526.2.
DR   AlphaFoldDB; Q9Z660; -.
DR   SMR; Q9Z660; -.
DR   STRING; 264203.ZMO1770; -.
DR   EnsemblBacteria; AAV90394; AAV90394; ZMO1770.
DR   GeneID; 58027476; -.
DR   KEGG; zmo:ZMO1770; -.
DR   eggNOG; COG0165; Bacteria.
DR   HOGENOM; CLU_027272_2_3_5; -.
DR   OMA; KKNPDVF; -.
DR   OrthoDB; 751464at2; -.
DR   UniPathway; UPA00068; UER00114.
DR   Proteomes; UP000001173; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004056; F:argininosuccinate lyase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR   CDD; cd01359; Argininosuccinate_lyase; 1.
DR   Gene3D; 1.10.275.10; -; 1.
DR   HAMAP; MF_00006; Arg_succ_lyase; 1.
DR   InterPro; IPR029419; Arg_succ_lyase_C.
DR   InterPro; IPR009049; Argininosuccinate_lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR020557; Fumarate_lyase_CS.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   PANTHER; PTHR43814; PTHR43814; 1.
DR   Pfam; PF14698; ASL_C2; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; SSF48557; 1.
DR   TIGRFAMs; TIGR00838; argH; 1.
DR   PROSITE; PS00163; FUMARATE_LYASES; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Arginine biosynthesis; Cytoplasm; Lyase;
KW   Reference proteome.
FT   CHAIN           1..468
FT                   /note="Argininosuccinate lyase"
FT                   /id="PRO_0000137857"
FT   CONFLICT        228
FT                   /note="A -> S (in Ref. 1; AAD19417)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   468 AA;  51079 MW;  CCAEDE1F2A5E8580 CRC64;
     MITERQTDSN AMWGGRFSEG PTAIMREINA SIPFDKRLWQ QDIAGSKAHL KMLVSRNIIT
     AEDGQKILEG LDKIAAEYAE KGVPEDWSLE DIHMVTEKRL ADLIGSAAGR LHTARSRNDQ
     VATDFKLWVR DAIDMVDKGL TALQTALVIR AEEHAATVMP GFTHLQIAQP ITLGHHLMAY
     YEMISRDRSR FSDGRKRLNQ SPLGAAALAG TGFNIDRHQT AKALGFDAPT ANSLDSVSDR
     DFALDYLMSA TQTAIHLSRL AEEIIIWASQ PYGFVSLPDA YSTGSSIMPQ KRNPDAAELV
     RGHSGRIAGC MNALVMTMKG LPLAYSKDMQ DDKPPVFEAH DLLSLAIAAM TGMIETLTFI
     PEKMRKTAEA GFSTATDLAD WLVRQAGIPF REAHHITGSA VRLAETKGIA LDALSIEDLK
     AIDPRIDESV KAVLSVDASV ASRNSYGGTA PDQVRARILD AKKTLGLN