ARM10_MOUSE
ID ARM10_MOUSE Reviewed; 306 AA.
AC Q9D0L7; Q80ZY2; Q9CUN3; Q9CZ87;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Armadillo repeat-containing protein 10;
GN Name=Armc10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N, and FVB/N-3; TISSUE=Colon, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic brain;
RX PubMed=15345747; DOI=10.1074/mcp.m400085-mcp200;
RA Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
RT "Phosphoproteomic analysis of the developing mouse brain.";
RL Mol. Cell. Proteomics 3:1093-1101(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43 AND THR-48, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play a role in cell survival and cell growth. May
CC suppress the transcriptional activity of p53/TP53 (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with the DNA-binding domain of p53/TP53.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Single-pass membrane protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D0L7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D0L7-2; Sequence=VSP_027363;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB29775.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK011303; BAB27529.1; -; mRNA.
DR EMBL; AK012872; BAB28526.1; -; mRNA.
DR EMBL; AK015272; BAB29775.1; ALT_FRAME; mRNA.
DR EMBL; BC038487; AAH38487.1; -; mRNA.
DR EMBL; BC046281; AAH46281.2; -; mRNA.
DR EMBL; BC058573; AAH58573.1; -; mRNA.
DR CCDS; CCDS19104.1; -. [Q9D0L7-1]
DR RefSeq; NP_080310.1; NM_026034.4. [Q9D0L7-1]
DR AlphaFoldDB; Q9D0L7; -.
DR SMR; Q9D0L7; -.
DR BioGRID; 212019; 2.
DR STRING; 10090.ENSMUSP00000072669; -.
DR iPTMnet; Q9D0L7; -.
DR PhosphoSitePlus; Q9D0L7; -.
DR SwissPalm; Q9D0L7; -.
DR EPD; Q9D0L7; -.
DR jPOST; Q9D0L7; -.
DR MaxQB; Q9D0L7; -.
DR PaxDb; Q9D0L7; -.
DR PeptideAtlas; Q9D0L7; -.
DR PRIDE; Q9D0L7; -.
DR ProteomicsDB; 282022; -. [Q9D0L7-1]
DR ProteomicsDB; 282023; -. [Q9D0L7-2]
DR Antibodypedia; 2627; 181 antibodies from 27 providers.
DR DNASU; 67211; -.
DR Ensembl; ENSMUST00000072896; ENSMUSP00000072669; ENSMUSG00000038525. [Q9D0L7-1]
DR Ensembl; ENSMUST00000148873; ENSMUSP00000120269; ENSMUSG00000038525. [Q9D0L7-2]
DR GeneID; 67211; -.
DR KEGG; mmu:67211; -.
DR UCSC; uc008wos.1; mouse. [Q9D0L7-1]
DR UCSC; uc008wot.1; mouse. [Q9D0L7-2]
DR CTD; 83787; -.
DR MGI; MGI:1914461; Armc10.
DR VEuPathDB; HostDB:ENSMUSG00000038525; -.
DR eggNOG; ENOG502RZRU; Eukaryota.
DR GeneTree; ENSGT00940000159546; -.
DR HOGENOM; CLU_037187_0_0_1; -.
DR InParanoid; Q9D0L7; -.
DR OMA; NNCLRVE; -.
DR OrthoDB; 860703at2759; -.
DR PhylomeDB; Q9D0L7; -.
DR TreeFam; TF335652; -.
DR BioGRID-ORCS; 67211; 3 hits in 74 CRISPR screens.
DR ChiTaRS; Armc10; mouse.
DR PRO; PR:Q9D0L7; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9D0L7; protein.
DR Bgee; ENSMUSG00000038525; Expressed in metanephric ureteric bud and 251 other tissues.
DR ExpressionAtlas; Q9D0L7; baseline and differential.
DR Genevisible; Q9D0L7; MM.
DR GO; GO:0005783; C:endoplasmic reticulum; ISO:MGI.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0050692; F:DNA binding domain binding; ISO:MGI.
DR GO; GO:0002039; F:p53 binding; ISO:MGI.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISO:MGI.
DR GO; GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; ISO:MGI.
DR GO; GO:0040010; P:positive regulation of growth rate; ISO:MGI.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR006911; ARM-rpt_dom.
DR InterPro; IPR016024; ARM-type_fold.
DR Pfam; PF04826; Arm_2; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Endoplasmic reticulum; Growth regulation; Membrane;
KW Phosphoprotein; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..306
FT /note="Armadillo repeat-containing protein 10"
FT /id="PRO_0000297708"
FT TRANSMEM 7..29
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 101..143
FT /note="ARM"
FT MOD_RES 43
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:15345747,
FT ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079"
FT MOD_RES 48
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 44..57
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027363"
FT CONFLICT 74
FT /note="P -> T (in Ref. 1; BAB29775)"
FT /evidence="ECO:0000305"
FT CONFLICT 191
FT /note="L -> P (in Ref. 1; BAB28526)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 306 AA; 33311 MW; 127912DC336B4E04 CRC64;
MGGARDVGWV AAGLVLGAGA CYCIYRLTRG PRRGGRRLRP SRSAEDLTDG SYDDILNAEQ
LKKLLYLLES TDDPVITEKA LVTLGNNAAF STNQAIIREL GGIPIVGNKI NSLNQSIKEK
ALNALNNLSV NVENQTKIKI YVPQVCEDVF ADPLNSAVQL AGLRLLTNMT VTNDYQHLLS
GSVAGLFHLL LLGNGSTKVQ VLKLLLNLSE NPAMTEGLLS VQVDSSFLSL YDGQVANEIL
LRALTLFQNI NNCLKVEGRL ANQIPFAKGS LFFLLYGEEC AQKMRALACH HDVDVKEKAL
AIKPKF
