ID   ARM10_RAT               Reviewed;         306 AA.
AC   B1WBW4;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Armadillo repeat-containing protein 10;
GN   Name=Armc10;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-43, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: May play a role in cell survival and cell growth. May
CC       suppress the transcriptional activity of p53/TP53 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with the DNA-binding domain of p53/TP53.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
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DR   EMBL; BC161913; AAI61913.1; -; mRNA.
DR   RefSeq; NP_001100046.2; NM_001106576.2.
DR   AlphaFoldDB; B1WBW4; -.
DR   SMR; B1WBW4; -.
DR   STRING; 10116.ENSRNOP00000042700; -.
DR   iPTMnet; B1WBW4; -.
DR   PhosphoSitePlus; B1WBW4; -.
DR   jPOST; B1WBW4; -.
DR   PaxDb; B1WBW4; -.
DR   PeptideAtlas; B1WBW4; -.
DR   PRIDE; B1WBW4; -.
DR   Ensembl; ENSRNOT00000044020; ENSRNOP00000042700; ENSRNOG00000012785.
DR   GeneID; 296758; -.
DR   KEGG; rno:296758; -.
DR   CTD; 83787; -.
DR   RGD; 1305915; Armc10.
DR   eggNOG; ENOG502RZRU; Eukaryota.
DR   GeneTree; ENSGT00940000159546; -.
DR   HOGENOM; CLU_037187_0_0_1; -.
DR   InParanoid; B1WBW4; -.
DR   OMA; NNCLRVE; -.
DR   OrthoDB; 860703at2759; -.
DR   PhylomeDB; B1WBW4; -.
DR   TreeFam; TF335652; -.
DR   PRO; PR:B1WBW4; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   Bgee; ENSRNOG00000012785; Expressed in ovary and 20 other tissues.
DR   Genevisible; B1WBW4; RN.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISO:RGD.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:1902254; P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator; IBA:GO_Central.
DR   GO; GO:0040008; P:regulation of growth; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR006911; ARM-rpt_dom.
DR   InterPro; IPR016024; ARM-type_fold.
DR   Pfam; PF04826; Arm_2; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   1: Evidence at protein level;
KW   Endoplasmic reticulum; Growth regulation; Membrane; Phosphoprotein;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..306
FT                   /note="Armadillo repeat-containing protein 10"
FT                   /id="PRO_0000346791"
FT   TRANSMEM        7..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REPEAT          101..143
FT                   /note="ARM"
FT   MOD_RES         43
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         48
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D0L7"
SQ   SEQUENCE   306 AA;  33422 MW;  C650BA2C13ECDED1 CRC64;
     MGGARDVGWV AAGLVLGAGA CYCIYRLTRG PRRGGRRLRP SRSAEDLTEG SYDAILSAEQ
     LEKLLYLLES TDDPIITEKA LVTLGNNAAF STNQAIIREL GGIPIVGSKI NSLNQSIKEK
     ALNALNNLSV NVENQTKIKI YVRQVCEDVF ADPLNSAVQL AALRLLTNMT VTNDYQHLLS
     NYITGLLHLL LIGNGSTKVQ VLKLLLNLSE NPAMTEGLLS AQVDSSFLSL YDGQMANEIL
     LRALTLFQNI NNCLRVEGRL ANQLPFAKGS LFFLLYGEEC AQKMKALACH PDVDVKEKAL
     AIKPKF