ARM12_MOUSE
ID ARM12_MOUSE Reviewed; 340 AA.
AC Q80X86; Q9D564; Q9DAN7;
DT 04-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Armadillo repeat-containing protein 12;
GN Name=Armc12;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH TBC1D15; TBC1D21; GK2;
RP IMMT; VDAC2 AND VDAC3, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RX PubMed=33536340; DOI=10.1073/pnas.2018355118;
RA Shimada K., Park S., Miyata H., Yu Z., Morohoshi A., Oura S., Matzuk M.M.,
RA Ikawa M.;
RT "ARMC12 regulates spatiotemporal mitochondrial dynamics during
RT spermiogenesis and is required for male fertility.";
RL Proc. Natl. Acad. Sci. U.S.A. 118:0-0(2021).
CC -!- FUNCTION: Essential for male fertility and sperm mitochondrial sheath
CC formation (PubMed:33536340). Required for proper mitochondrial
CC elongation and coiling along the flagellum during the formation of the
CC mitochondrial sheath (PubMed:33536340). Facilitates the growth and
CC aggressiveness of neuroblastoma cells (By similarity). Increases the
CC EZH2 activity and H3K27me3 levels in a RBBP4-dependent manner, and
CC facilitates the enrichment of polycomb repressive complex 2 and
CC H3K27me3 on gene promoters, resulting in transcriptional repression of
CC tumor suppressors affecting the proliferation, invasion, and metastasis
CC of tumor cells (By similarity). {ECO:0000250|UniProtKB:Q5T9G4,
CC ECO:0000269|PubMed:33536340}.
CC -!- SUBUNIT: Interacts with TBC1D15, TBC1D21, GK2 and IMMT
CC (PubMed:33536340). Interacts with VDAC2 and VDAC3 in a TBC1D21-
CC dependent manner (PubMed:33536340). Interacts (via ARM domains) with
CC RBBP4 (By similarity). {ECO:0000250|UniProtKB:Q5T9G4,
CC ECO:0000269|PubMed:33536340}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5T9G4}.
CC Mitochondrion outer membrane {ECO:0000269|PubMed:33536340}; Peripheral
CC membrane protein {ECO:0000269|PubMed:33536340}.
CC -!- TISSUE SPECIFICITY: Testis-specific. {ECO:0000269|PubMed:33536340}.
CC -!- DEVELOPMENTAL STAGE: Expression begins around postnatal day 20, which
CC roughly corresponds to the haploid, round spermatid stage of
CC spermatogenesis. {ECO:0000269|PubMed:33536340}.
CC -!- DISRUPTION PHENOTYPE: Male mice are infertile due to reduced sperm
CC motility and abnormal sperm morphology. {ECO:0000269|PubMed:33536340}.
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DR EMBL; AK005672; BAB24180.1; -; mRNA.
DR EMBL; AK015756; BAB29960.1; -; mRNA.
DR EMBL; BC049559; AAH49559.1; -; mRNA.
DR CCDS; CCDS28579.1; -.
DR RefSeq; NP_080566.2; NM_026290.3.
DR AlphaFoldDB; Q80X86; -.
DR SMR; Q80X86; -.
DR STRING; 10090.ENSMUSP00000025060; -.
DR PhosphoSitePlus; Q80X86; -.
DR PaxDb; Q80X86; -.
DR PRIDE; Q80X86; -.
DR ProteomicsDB; 277290; -.
DR Antibodypedia; 29544; 24 antibodies from 9 providers.
DR Ensembl; ENSMUST00000233923; ENSMUSP00000156794; ENSMUSG00000024223.
DR GeneID; 67645; -.
DR KEGG; mmu:67645; -.
DR UCSC; uc008brd.2; mouse.
DR CTD; 221481; -.
DR MGI; MGI:1914895; Armc12.
DR VEuPathDB; HostDB:ENSMUSG00000024223; -.
DR eggNOG; ENOG502QTRM; Eukaryota.
DR GeneTree; ENSGT00390000003856; -.
DR HOGENOM; CLU_070346_0_0_1; -.
DR InParanoid; Q80X86; -.
DR OMA; CQPPLCS; -.
DR OrthoDB; 806221at2759; -.
DR PhylomeDB; Q80X86; -.
DR TreeFam; TF337134; -.
DR BioGRID-ORCS; 67645; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q80X86; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q80X86; protein.
DR Bgee; ENSMUSG00000024223; Expressed in seminiferous tubule of testis and 21 other tissues.
DR ExpressionAtlas; Q80X86; baseline and differential.
DR Genevisible; Q80X86; MM.
DR GO; GO:0019898; C:extrinsic component of membrane; IDA:UniProtKB.
DR GO; GO:0005741; C:mitochondrial outer membrane; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0030317; P:flagellated sperm motility; IMP:UniProtKB.
DR GO; GO:0030307; P:positive regulation of cell growth; ISS:UniProtKB.
DR GO; GO:0120317; P:sperm mitochondrial sheath assembly; IMP:UniProtKB.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR006911; ARM-rpt_dom.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR042834; Armc12.
DR PANTHER; PTHR47144; PTHR47144; 1.
DR Pfam; PF04826; Arm_2; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Differentiation; Membrane; Mitochondrion; Mitochondrion outer membrane;
KW Nucleus; Reference proteome; Repeat; Spermatogenesis.
FT CHAIN 1..340
FT /note="Armadillo repeat-containing protein 12"
FT /id="PRO_0000230164"
FT REPEAT 100..139
FT /note="ARM 1"
FT REPEAT 179..218
FT /note="ARM 2"
FT REPEAT 278..318
FT /note="ARM 3"
FT REGION 1..101
FT /note="Interaction with TBC1D15"
FT /evidence="ECO:0000269|PubMed:33536340"
FT REGION 321..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 194
FT /note="L -> V (in Ref. 1; BAB24180)"
FT /evidence="ECO:0000305"
FT CONFLICT 328
FT /note="S -> P (in Ref. 1; BAB29960)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 340 AA; 38530 MW; 35BB5BBB6087C186 CRC64;
MGKTIPRFLE QLDLIKSFVG LATGAGALYL LYKAVRTGLK CHPPLCSNSP ICIARLAIER
ERHGRDSGEI RRLLNSLDCK QDEYTRSMIL HNITRCVYLL EAEASSCTMD DIDLVADMLD
EKDNSVKIQA LNALKAFSGI RKFRLKIQEH CIKVLELIST IWDLELHVAG LRLLNNLPLP
DYVHPQLRRV MPALMEIIQS DCILAQVQAV RLLSYLAQKN DLLYDILNCQ VRPNFLNLFQ
SSQPGSLLFE VLVFAEHLSE GRNATHYRAV KWHYNEQSLH EALFGDESRL ADRLLSLVIH
PEEEVQIQAC KVIVSLQCPQ DLGSRPSSCR PSHSCFKTGK
