ARMC3_HUMAN
ID ARMC3_HUMAN Reviewed; 872 AA.
AC Q5W041; A0PG76; A6NH64; B4DZL3; B7ZBN6; B7ZBN7; Q8IXS5; Q8N7B0; Q96M49;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Armadillo repeat-containing protein 3;
DE AltName: Full=Beta-catenin-like protein;
DE AltName: Full=Cancer/testis antigen 81;
DE Short=CT81;
DE AltName: Full=KU-CT-1;
GN Name=ARMC3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), AND TISSUE SPECIFICITY.
RC TISSUE=Fetal brain;
RX PubMed=16915934;
RA Li X., Liu B., Ji C.N., Kang Y., Mao Y.;
RT "Cloning and expression of ARMC3_v2, a novel splicing variant of the human
RT ARMC3 gene.";
RL Genetika 42:999-1003(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 459-875 (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT GLN-626.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), TISSUE SPECIFICITY, AND
RP IDENTIFICATION AS A CANCER/TESTIS ANTIGEN.
RC TISSUE=Testis;
RX PubMed=16397042; DOI=10.1158/1078-0432.ccr-05-1206;
RA Okada T., Akada M., Fujita T., Iwata T., Goto Y., Kido K., Okada T.,
RA Matsuzaki Y., Kobayashi K., Matsuno S., Sunamura M., Kawakami Y.;
RT "A novel cancer testis antigen that is frequently expressed in pancreatic,
RT lung, and endometrial cancers.";
RL Clin. Cancer Res. 12:191-197(2006).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1; Synonyms=ARMC3_Nu1, KU-CT-1L;
CC IsoId=Q5W041-2; Sequence=Displayed;
CC Name=3; Synonyms=ARMC3_Nu2;
CC IsoId=Q5W041-3; Sequence=VSP_024500, VSP_024501;
CC Name=4;
CC IsoId=Q5W041-4; Sequence=VSP_024498;
CC Name=5; Synonyms=KU-CT-1;
CC IsoId=Q5W041-5; Sequence=VSP_028551, VSP_028552;
CC -!- TISSUE SPECIFICITY: Isoform 1 is expressed in skeletal muscle, brain,
CC lung, kidney, prostate and testis. Isoform 3 is mainly expressed in
CC skeletal muscle, liver, spleen and thymus. Expressed in many cancer
CC tissues and cell lines. {ECO:0000269|PubMed:16397042,
CC ECO:0000269|PubMed:16915934}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05389.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY436643; AAR99738.1; -; mRNA.
DR EMBL; AK057389; BAB71463.1; -; mRNA.
DR EMBL; AK098711; BAC05389.1; ALT_INIT; mRNA.
DR EMBL; AL139815; CAX14862.1; -; Genomic_DNA.
DR EMBL; AC079269; CAX14862.1; JOINED; Genomic_DNA.
DR EMBL; AL139815; CAX14863.1; -; Genomic_DNA.
DR EMBL; AC079269; CAX14863.1; JOINED; Genomic_DNA.
DR EMBL; AK302985; BAG64125.1; -; mRNA.
DR EMBL; AL139815; CAH72189.2; -; Genomic_DNA.
DR EMBL; AC079269; CAH72189.2; JOINED; Genomic_DNA.
DR EMBL; BC039312; AAH39312.1; -; mRNA.
DR CCDS; CCDS60499.1; -. [Q5W041-3]
DR CCDS; CCDS60500.1; -. [Q5W041-4]
DR CCDS; CCDS7142.1; -. [Q5W041-2]
DR RefSeq; NP_001269674.1; NM_001282745.1. [Q5W041-4]
DR RefSeq; NP_001269675.1; NM_001282746.1. [Q5W041-3]
DR RefSeq; NP_001269676.1; NM_001282747.1.
DR RefSeq; NP_775104.2; NM_173081.4. [Q5W041-2]
DR AlphaFoldDB; Q5W041; -.
DR SMR; Q5W041; -.
DR BioGRID; 128563; 4.
DR IntAct; Q5W041; 2.
DR STRING; 9606.ENSP00000298032; -.
DR iPTMnet; Q5W041; -.
DR PhosphoSitePlus; Q5W041; -.
DR BioMuta; ARMC3; -.
DR DMDM; 215273946; -.
DR EPD; Q5W041; -.
DR MassIVE; Q5W041; -.
DR MaxQB; Q5W041; -.
DR PaxDb; Q5W041; -.
DR PeptideAtlas; Q5W041; -.
DR PRIDE; Q5W041; -.
DR ProteomicsDB; 65747; -. [Q5W041-2]
DR ProteomicsDB; 65748; -. [Q5W041-3]
DR ProteomicsDB; 65749; -. [Q5W041-4]
DR ProteomicsDB; 65750; -. [Q5W041-5]
DR Antibodypedia; 44327; 90 antibodies from 18 providers.
DR DNASU; 219681; -.
DR Ensembl; ENST00000298032.10; ENSP00000298032.5; ENSG00000165309.14. [Q5W041-2]
DR Ensembl; ENST00000409049.7; ENSP00000387288.3; ENSG00000165309.14. [Q5W041-3]
DR Ensembl; ENST00000409983.7; ENSP00000386943.3; ENSG00000165309.14. [Q5W041-4]
DR GeneID; 219681; -.
DR KEGG; hsa:219681; -.
DR MANE-Select; ENST00000298032.10; ENSP00000298032.5; NM_173081.5; NP_775104.2.
DR UCSC; uc001irm.6; human. [Q5W041-2]
DR CTD; 219681; -.
DR DisGeNET; 219681; -.
DR GeneCards; ARMC3; -.
DR HGNC; HGNC:30964; ARMC3.
DR HPA; ENSG00000165309; Group enriched (brain, choroid plexus, fallopian tube, testis).
DR MIM; 611226; gene.
DR neXtProt; NX_Q5W041; -.
DR OpenTargets; ENSG00000165309; -.
DR PharmGKB; PA134917281; -.
DR VEuPathDB; HostDB:ENSG00000165309; -.
DR eggNOG; KOG0167; Eukaryota.
DR GeneTree; ENSGT00940000157476; -.
DR HOGENOM; CLU_018048_0_0_1; -.
DR InParanoid; Q5W041; -.
DR OMA; LYPMQSR; -.
DR OrthoDB; 206276at2759; -.
DR PhylomeDB; Q5W041; -.
DR TreeFam; TF329738; -.
DR PathwayCommons; Q5W041; -.
DR SignaLink; Q5W041; -.
DR BioGRID-ORCS; 219681; 10 hits in 1055 CRISPR screens.
DR ChiTaRS; ARMC3; human.
DR GenomeRNAi; 219681; -.
DR Pharos; Q5W041; Tbio.
DR PRO; PR:Q5W041; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q5W041; protein.
DR Bgee; ENSG00000165309; Expressed in right uterine tube and 107 other tissues.
DR ExpressionAtlas; Q5W041; baseline and differential.
DR Genevisible; Q5W041; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR Gene3D; 1.25.10.10; -; 3.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR Pfam; PF00514; Arm; 3.
DR SMART; SM00185; ARM; 10.
DR SUPFAM; SSF48371; SSF48371; 2.
DR PROSITE; PS50176; ARM_REPEAT; 4.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Repeat.
FT CHAIN 1..872
FT /note="Armadillo repeat-containing protein 3"
FT /id="PRO_0000284403"
FT REPEAT 15..54
FT /note="ARM 1"
FT REPEAT 57..96
FT /note="ARM 2"
FT REPEAT 98..138
FT /note="ARM 3"
FT REPEAT 140..179
FT /note="ARM 4"
FT REPEAT 181..220
FT /note="ARM 5"
FT REPEAT 222..262
FT /note="ARM 6"
FT REPEAT 264..304
FT /note="ARM 7"
FT REPEAT 306..345
FT /note="ARM 8"
FT REPEAT 346..385
FT /note="ARM 9"
FT REPEAT 388..427
FT /note="ARM 10"
FT REPEAT 429..468
FT /note="ARM 11"
FT REPEAT 470..509
FT /note="ARM 12"
FT REGION 610..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..693
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 392..397
FT /note="NAAAEA -> KEMEHE (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16397042"
FT /id="VSP_028551"
FT VAR_SEQ 398..872
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16397042"
FT /id="VSP_028552"
FT VAR_SEQ 643..650
FT /note="KKNSYHFS -> N (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_024498"
FT VAR_SEQ 682..688
FT /note="RKSKGKK -> SSLPTSR (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16915934"
FT /id="VSP_024500"
FT VAR_SEQ 689..872
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16915934"
FT /id="VSP_024501"
FT VARIANT 345
FT /note="E -> G (in dbSNP:rs16922864)"
FT /id="VAR_050669"
FT VARIANT 608
FT /note="S -> P (in dbSNP:rs11013233)"
FT /id="VAR_050670"
FT VARIANT 626
FT /note="R -> Q (in dbSNP:rs10828395)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_050671"
FT CONFLICT 586
FT /note="P -> S (in Ref. 2; BAB71463)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 872 AA; 96405 MW; 02ED1C432D961857 CRC64;
MGKKIKKEVE PPPKDVFDPL MIESKKAATV VLMLNSPEEE ILAKACEAIY KFALKGEENK
TTLLELGAVE PLTKLLTHED KIVRRNATMI FGILASNNDV KKLLRELDVM NSVIAQLAPE
EEVVIHEFAS LCLANMSAEY TSKVQIFEHG GLEPLIRLLS SPDPDVKKNS MECIYNLVQD
FQCRAKLQEL NAIPPILDLL KSEYPVIQLL ALKTLGVIAN DKESRTMLRD NQGLDHLIKI
LETKELNDLH IEALAVIANC LEDMDTMVQI QQTGGLKKLL SFAENSTIPD IQKNAAKAIT
KAAYDPENRK LFHEQEVEKC LVALLGSEND GTKIAASQAI SAMCENSGSK DFFNNQGIPQ
LIQLLKSDNE EVREAAALAL ANLTTCNPAN ANAAAEADGI DPLINLLSSK RDGAIANAAT
VLTNMAMQEP LRLNIQNHDI MHAIISPLRS ANTVVQSKAA LAVTATACDV EARTELRNSG
GLEPLVELLR SKNDEVRKHA SWAVMVCAGD ELTANELCRL GALDILEEVN VSGTRKNKFS
EAAYNKLLNN NLSLKYSQTG YLSSSNIIND GFYDYGRINP GTKLLPLKEL CLQEPSDLRA
VLLINSKSYV SPPSSMEDKS DVGYGRSISS SSSLRRSSKE KNKKNSYHFS AGFGSPIEDK
SEPASGRNTV LSKSATKEKG WRKSKGKKEE EKVKEEEEVM VVPKFVGEGS SDKEWCPPSD
PDFSMYVYEV TKSILPITNI KEQIEDLAKY VAEKMGGKIP KEKLPDFSWE LHISELKFQL
KSNVIPIGHV KKGIFYHRAL LFKALADRIG IGCSLVRGEY GRAWNEVMLQ NDSRKGVIGG
LPAPEMYVID LMFHPGGLMK LRSREADLYR FI
