ARMC5_MOUSE
ID ARMC5_MOUSE Reviewed; 926 AA.
AC Q5EBP3; Q6KAU6; Q8CDI5; Q8R3J0;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Armadillo repeat-containing protein 5 {ECO:0000305};
GN Name=Armc5 {ECO:0000312|MGI:MGI:2384586};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryonic tail;
RX PubMed=15449545; DOI=10.1093/dnares/11.2.127;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Kitamura H., Nakagawa T., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of FLJ genes: the
RT complete nucleotide sequences of 110 mouse FLJ-homologous cDNAs identified
RT by screening of terminal sequences of cDNA clones randomly sampled from
RT size-fractionated libraries.";
RL DNA Res. 11:127-135(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N-3; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 126-926.
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY, INDUCTION BY CD3E AND
RP CD28, AND SUBCELLULAR LOCATION.
RX PubMed=28169274; DOI=10.1038/ncomms13834;
RA Hu Y., Lao L., Mao J., Jin W., Luo H., Charpentier T., Qi S., Peng J.,
RA Hu B., Marcinkiewicz M.M., Lamarre A., Wu J.;
RT "Armc5 deletion causes developmental defects and compromises T-cell immune
RT responses.";
RL Nat. Commun. 8:13834-13834(2017).
CC -!- FUNCTION: Involved in fetal development, T-cell function and adrenal
CC gland growth homeostasis (PubMed:28169274). Negatively regulates
CC adrenal cells survival. Plays a role in steroidogenesis, modulates
CC steroidogenic enzymes expression and cortisol production (By
CC similarity). {ECO:0000250|UniProtKB:Q96C12,
CC ECO:0000269|PubMed:28169274}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28169274}.
CC -!- TISSUE SPECIFICITY: Expression is high in the thymus, stomach, bone
CC marrow and lymphatic tissues (including lymph nodes and intestinal
CC wall). Also expressed in the adrenal gland, skin and in brain
CC structures, with noticeable levels found in the cerebellum.
CC {ECO:0000269|PubMed:28169274}.
CC -!- INDUCTION: In CD4(+) T-cells, mRNA expression is induced 2h after CD3E
CC plus CD28 stimulation, then subsides and remains low between 24 and 72h
CC post-activation. {ECO:0000269|PubMed:28169274}.
CC -!- DISRUPTION PHENOTYPE: Embryonic lethality, with its severity depending
CC on genetic background of the mice: embryonic lethality becomes more
CC severe with higher degrees of genetic background purity
CC (PubMed:28169274). Knockout mice are small in body size. They have
CC compromised T-cell proliferation and differentiation into Th1 and Th17
CC cells, increased T-cell apoptosis, reduced severity of experimental
CC autoimmune encephalitis, and defective immune responses to lymphocytic
CC choriomeningitis virus infection. They develop adrenal gland
CC hyperplasia in old age (PubMed:28169274).
CC {ECO:0000269|PubMed:28169274}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC26726.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAD21361.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK131111; BAD21361.1; ALT_INIT; mRNA.
DR EMBL; BC025196; AAH25196.1; -; mRNA.
DR EMBL; BC089363; AAH89363.1; -; mRNA.
DR EMBL; AK030000; BAC26726.1; ALT_INIT; mRNA.
DR CCDS; CCDS21892.1; -.
DR RefSeq; NP_666317.2; NM_146205.2.
DR AlphaFoldDB; Q5EBP3; -.
DR SMR; Q5EBP3; -.
DR STRING; 10090.ENSMUSP00000040568; -.
DR PhosphoSitePlus; Q5EBP3; -.
DR EPD; Q5EBP3; -.
DR MaxQB; Q5EBP3; -.
DR PaxDb; Q5EBP3; -.
DR PeptideAtlas; Q5EBP3; -.
DR PRIDE; Q5EBP3; -.
DR ProteomicsDB; 277294; -.
DR Antibodypedia; 51623; 84 antibodies from 19 providers.
DR Ensembl; ENSMUST00000044660; ENSMUSP00000040568; ENSMUSG00000042178.
DR GeneID; 233912; -.
DR KEGG; mmu:233912; -.
DR UCSC; uc009jyk.1; mouse.
DR CTD; 79798; -.
DR MGI; MGI:2384586; Armc5.
DR VEuPathDB; HostDB:ENSMUSG00000042178; -.
DR eggNOG; ENOG502QSYU; Eukaryota.
DR GeneTree; ENSGT00390000009109; -.
DR HOGENOM; CLU_007517_0_0_1; -.
DR InParanoid; Q5EBP3; -.
DR OMA; YIIPEME; -.
DR OrthoDB; 174815at2759; -.
DR PhylomeDB; Q5EBP3; -.
DR TreeFam; TF337762; -.
DR BioGRID-ORCS; 233912; 17 hits in 75 CRISPR screens.
DR PRO; PR:Q5EBP3; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q5EBP3; protein.
DR Bgee; ENSMUSG00000042178; Expressed in paneth cell and 235 other tissues.
DR Genevisible; Q5EBP3; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005925; C:focal adhesion; ISO:MGI.
DR GO; GO:0016020; C:membrane; IDA:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0035801; P:adrenal cortex development; IMP:MGI.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0043367; P:CD4-positive, alpha-beta T cell differentiation; IMP:MGI.
DR GO; GO:0048468; P:cell development; IMP:MGI.
DR GO; GO:0051607; P:defense response to virus; IMP:MGI.
DR GO; GO:0007369; P:gastrulation; IMP:MGI.
DR GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
DR GO; GO:0001707; P:mesoderm formation; IMP:MGI.
DR GO; GO:0050810; P:regulation of steroid biosynthetic process; IMP:MGI.
DR GO; GO:0042098; P:T cell proliferation; IMP:MGI.
DR Gene3D; 1.25.10.10; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF00651; BTB; 1.
DR SMART; SM00185; ARM; 5.
DR SUPFAM; SSF48371; SSF48371; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..926
FT /note="Armadillo repeat-containing protein 5"
FT /id="PRO_0000284406"
FT REPEAT 139..179
FT /note="ARM 1"
FT REPEAT 181..221
FT /note="ARM 2"
FT REPEAT 223..263
FT /note="ARM 3"
FT REPEAT 267..306
FT /note="ARM 4"
FT REPEAT 307..354
FT /note="ARM 5"
FT REPEAT 355..399
FT /note="ARM 6"
FT REPEAT 401..440
FT /note="ARM 7"
FT DOMAIN 745..813
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT REGION 82..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 472..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 337
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96C12"
SQ SEQUENCE 926 AA; 96728 MW; E8475D8244BFC648 CRC64;
MAAARPALTD SLSFCLAQLT AAAGEGPGGG KDPATNETPL GRALLALRTR HIKAAEGIER
FRARGGLRPL LALLRRTAAA GPAPSQAASG SAPSSVASAG STPGHAPAAE SLLTPSLPMR
LRKTLDLALS ILANCCTEGA CRAEVRRLGG ILPLVTILQC VKTDSIQNRT ARALGNLAME
PESCRDIHSA GAVPFLVESL TACQDSQCLQ SIVRALRNLA DSPQHRLALA QQGAVRPLAE
LLATAPDPAL TAALVRALLE LSRGCSRACA EQLSLGGALG PLVSLASHPK RAIREAAILI
LANLCAQGLV RPALGNAGGV EVLLGELRRR RSPGGSSSAT QQPLVRAVCL LCREAINRAR
LRDAGGLELL MGLLQDPGAS AWHPRVVAAL VGFLYDTGAL GKLQALGLVP LLARQLCGEA
GEEEEEGIEA ASWDFPEERT SGQAEGGSFR SLRLWLISEG YAAGPGDISP DWSPERCPMP
EPSESVSPTP GQTSMSTPRT LRKPGRIPAA TPEEPWGQEG PALLLLSRFS QAPDPSGALV
TGPALCGLLA YVTGAPGPPN PRALRILARL TCNPACLEAF VRTYGAALLR AWLVLGVSPD
DWPVPHARPV HRSQHRELGE MLLQNLTVQA ESPFGVGALT HLLLSGSPED RVACALTLPF
ICRKPTLWRR LLLDQGGLRL LLTALTQPAP HPLFLFFAAD SLSCLQGLVS PTASPVPLPA
LPLELDSPPP CLYEPLLGPA PAPAPDLHFV LDSGLQLPAQ RAASAAASPF FRALLSGSFA
EAQMDLVPLR GLSPGAAWPV LHHLHGCRGC GAALGPVPPP GQPLLGSKAE EALEAAGRFL
LPALEEELEE AVGRIHLSPR GGPESVGEVF RLGRPRLAAH CARWTLEPGQ CPRKRALALT
GLVEAAGEEA GPLTEALLAV VMGIES
