ID   ARMC5_RAT               Reviewed;         926 AA.
AC   Q5PQP9;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Armadillo repeat-containing protein 5 {ECO:0000305};
GN   Name=Armc5 {ECO:0000312|RGD:1306553};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Involved in fetal development, T-cell function and adrenal
CC       gland growth homeostasis (By similarity). Negatively regulates adrenal
CC       cells survival. Plays a role in steroidogenesis, modulates
CC       steroidogenic enzymes expression and cortisol production (By
CC       similarity). {ECO:0000250|UniProtKB:Q5EBP3,
CC       ECO:0000250|UniProtKB:Q96C12}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96C12}.
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DR   EMBL; BC087086; AAH87086.1; -; mRNA.
DR   RefSeq; NP_001009455.1; NM_001009455.1.
DR   RefSeq; XP_017444905.1; XM_017589416.1.
DR   AlphaFoldDB; Q5PQP9; -.
DR   SMR; Q5PQP9; -.
DR   STRING; 10116.ENSRNOP00000027032; -.
DR   PaxDb; Q5PQP9; -.
DR   Ensembl; ENSRNOT00000027032; ENSRNOP00000027032; ENSRNOG00000019935.
DR   GeneID; 361653; -.
DR   KEGG; rno:361653; -.
DR   UCSC; RGD:1306553; rat.
DR   CTD; 79798; -.
DR   RGD; 1306553; Armc5.
DR   eggNOG; ENOG502QSYU; Eukaryota.
DR   GeneTree; ENSGT00390000009109; -.
DR   HOGENOM; CLU_007517_0_0_1; -.
DR   InParanoid; Q5PQP9; -.
DR   OMA; YIIPEME; -.
DR   OrthoDB; 174815at2759; -.
DR   PhylomeDB; Q5PQP9; -.
DR   TreeFam; TF337762; -.
DR   PRO; PR:Q5PQP9; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000019935; Expressed in thymus and 20 other tissues.
DR   Genevisible; Q5PQP9; RN.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR   GO; GO:0016020; C:membrane; ISO:RGD.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0035801; P:adrenal cortex development; ISO:RGD.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0043367; P:CD4-positive, alpha-beta T cell differentiation; ISO:RGD.
DR   GO; GO:0048468; P:cell development; IEA:Ensembl.
DR   GO; GO:0051607; P:defense response to virus; ISO:RGD.
DR   GO; GO:0007369; P:gastrulation; ISO:RGD.
DR   GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
DR   GO; GO:0001707; P:mesoderm formation; ISO:RGD.
DR   GO; GO:0050810; P:regulation of steroid biosynthetic process; ISO:RGD.
DR   GO; GO:0042098; P:T cell proliferation; ISO:RGD.
DR   Gene3D; 1.25.10.10; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF00651; BTB; 1.
DR   SMART; SM00185; ARM; 5.
DR   SUPFAM; SSF48371; SSF48371; 2.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Phosphoprotein; Reference proteome; Repeat.
FT   CHAIN           1..926
FT                   /note="Armadillo repeat-containing protein 5"
FT                   /id="PRO_0000284407"
FT   REPEAT          139..179
FT                   /note="ARM 1"
FT   REPEAT          181..221
FT                   /note="ARM 2"
FT   REPEAT          223..263
FT                   /note="ARM 3"
FT   REPEAT          267..306
FT                   /note="ARM 4"
FT   REPEAT          307..354
FT                   /note="ARM 5"
FT   REPEAT          355..399
FT                   /note="ARM 6"
FT   REPEAT          401..440
FT                   /note="ARM 7"
FT   DOMAIN          745..813
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   REGION          82..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          467..498
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         337
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96C12"
SQ   SEQUENCE   926 AA;  96585 MW;  80B010EBFD838C90 CRC64;
     MAAARPALTD SLSFCLAQLT AAAGEGPGGG KDPATNETAL GRVLLALRTR HIKAAEGIER
     FRARGGLRPL VALLRRTAAA GPAPSQAASG SAPPSVASAG SSPGPAPAAE SPLTLSAPMR
     LRKTLDLALS ILANCCTEGA CRSEVRRIGG ILPLVTILQC VRIDSIQNRT ARALGNLAME
     PESCGDIHSA GAVPFLVESL TACQDSQCLQ SIVRALRNLA DSPQHRLALA QQGAVRPLAE
     LLATAPDPAL TSALVRALLE LSRGCSRACA EQLSLGGGLG PLVSLASHPK RAIREAAILI
     LANLCAQGLV RPALGNAGGV EVLLGELRRR RGPSGSSSAS QQPLVRAVCL LCREAINRAR
     LRDAGGLELL MGLLQDPGAS AWHPRVVAAL VGFLYDTGAL GKLQALGLVP LLARQLCGEA
     GEEEEEGVEA ASWDFPEERT SGQPEGGSFR SLRLWLISEG YAAGPGDISP DWSPERCPMP
     EPSESVSPTP GQTSMSTPRT LRKLGRVPAA TTEEPWGQEG PALLLLSRFS QAPDPSGALV
     TGPALCGLLA YVTGAPGPPN PRALRILARL TCNPACLEAF VRSYGAALLR AWLVLGVSPD
     DWPVPHARPV HRSQHRELGE MLLQNLTVQA ESPFGVGALT HLLLSGSPED RVACALTVPF
     ICRKPTLWRR LLLDQGGLRL LLTALTQPAP HPLFLFFAAD SLSCLQGLVS PSASPVPLPD
     LPLELDSPSP CLYKPLLGPA PAPAPDLHFV LDSGLQLPAQ RAASAAASPF FRALLSGSFA
     EAQMNLVPLR GLSPSAAWPV LHHLHGCRGC GAALGPIPPP GQPLLGSKAE EALEAAGRFL
     LPALEEELEE AVGRIHLSPQ GGPESVGEVF RLGRPRLAAH CARWTLEPGQ CPRKRALALT
     GLVEAAGEEA GPLTEALLAV VMGVES