ARMC6_DROME
ID ARMC6_DROME Reviewed; 464 AA.
AC Q7K486;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Armadillo repeat-containing protein 6 homolog;
GN ORFNames=CG5721;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-9, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- SIMILARITY: Belongs to the ARMC6 family. {ECO:0000305}.
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DR EMBL; AE013599; AAF57729.1; -; Genomic_DNA.
DR EMBL; AY052110; AAK93534.1; -; mRNA.
DR RefSeq; NP_611306.1; NM_137462.4.
DR AlphaFoldDB; Q7K486; -.
DR SMR; Q7K486; -.
DR BioGRID; 62765; 5.
DR IntAct; Q7K486; 1.
DR STRING; 7227.FBpp0085950; -.
DR iPTMnet; Q7K486; -.
DR PaxDb; Q7K486; -.
DR PRIDE; Q7K486; -.
DR EnsemblMetazoa; FBtr0086771; FBpp0085950; FBgn0034315.
DR GeneID; 37084; -.
DR KEGG; dme:Dmel_CG5721; -.
DR UCSC; CG5721-RA; d. melanogaster.
DR FlyBase; FBgn0034315; CG5721.
DR VEuPathDB; VectorBase:FBgn0034315; -.
DR eggNOG; KOG4199; Eukaryota.
DR GeneTree; ENSGT00390000002913; -.
DR HOGENOM; CLU_039447_1_0_1; -.
DR InParanoid; Q7K486; -.
DR OMA; QRNGAWA; -.
DR OrthoDB; 605325at2759; -.
DR PhylomeDB; Q7K486; -.
DR BioGRID-ORCS; 37084; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 37084; -.
DR PRO; PR:Q7K486; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0034315; Expressed in saliva-secreting gland and 23 other tissues.
DR Genevisible; Q7K486; DM.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR040104; ARMC6.
DR PANTHER; PTHR22895:SF0; PTHR22895:SF0; 1.
DR SMART; SM00185; ARM; 4.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..464
FT /note="Armadillo repeat-containing protein 6 homolog"
FT /id="PRO_0000355638"
FT REPEAT 235..275
FT /note="ARM 1"
FT REPEAT 287..331
FT /note="ARM 2"
FT REPEAT 332..374
FT /note="ARM 3"
FT REPEAT 375..418
FT /note="ARM 4"
FT MOD_RES 9
FT /note="Phosphothreonine"
FT /evidence="ECO:0000269|PubMed:18327897"
SQ SEQUENCE 464 AA; 51378 MW; DCE84B246D3D8B4D CRC64;
MAKVISQDTF DDVVKENVVE FSMTPSEAKE ETIKQFEAQG INLANIIKDL SVNPQTGQPV
INETVDKIKE HIGQKLEETT ELLEQLATLD AECKKSLAHR VLAGKNGAHD ALITLLEETL
SAESPNESVL KKSLEAINSL THKQPDLFDA EAMAVVLKLL ALKVESEEVT LLTLQWLQKA
CIMHEMNRQN IMNTSALKLM KPLLGKGKDR LVRELTAVFR FLVLDDDIRV EFGCAHEHAR
QIAGEVLITL VELLPAYQDP NVLADLLLTI GTLAVRQELC TAIDEAGGLK SVFEIMSSNL
DEVRLNREAL KLLRALAGQD SVKSHIVQQG VAPIIKQLLE THQSNENIVA AALACVTTLT
LRVQEHSAAF FDTGIAEVIV EALRAHPKHK IVQRNGAWAI RNMVSRSRNQ CETWISFGVE
DLLNMAMKEH PSVEQDIKAA LRDLGCSVHL REEWTGTAEK KIAA
