ARMC6_HUMAN
ID ARMC6_HUMAN Reviewed; 501 AA.
AC Q6NXE6; B4DI98; O94999; Q9BTH5;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Armadillo repeat-containing protein 6;
GN Name=ARMC6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Cervix, and Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-64, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic kidney;
RX PubMed=17525332; DOI=10.1126/science.1140321;
RA Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E.,
RA Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y.,
RA Gygi S.P., Elledge S.J.;
RT "ATM and ATR substrate analysis reveals extensive protein networks
RT responsive to DNA damage.";
RL Science 316:1160-1166(2007).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [7]
RP METHYLATION AT HIS-263, AND MUTAGENESIS OF HIS-261; ALA-262; HIS-263;
RP ASN-264; HIS-265; ALA-266 AND LYS-267.
RX PubMed=33563959; DOI=10.1038/s41467-020-20670-7;
RA Davydova E., Shimazu T., Schuhmacher M.K., Jakobsson M.E.,
RA Willemen H.L.D.M., Liu T., Moen A., Ho A.Y.Y., Malecki J., Schroer L.,
RA Pinto R., Suzuki T., Groensberg I.A., Sohtome Y., Akakabe M., Weirich S.,
RA Kikuchi M., Olsen J.V., Dohmae N., Umehara T., Sodeoka M., Siino V.,
RA McDonough M.A., Eijkelkamp N., Schofield C.J., Jeltsch A., Shinkai Y.,
RA Falnes P.O.;
RT "The methyltransferase METTL9 mediates pervasive 1-methylhistidine
RT modification in mammalian proteomes.";
RL Nat. Commun. 12:891-891(2021).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6NXE6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6NXE6-2; Sequence=VSP_040103;
CC -!- PTM: Methylated at His-263 by METTL9. {ECO:0000269|PubMed:33563959}.
CC -!- SIMILARITY: Belongs to the ARMC6 family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-26 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD03162.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAH67125.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK295488; BAG58410.1; -; mRNA.
DR EMBL; AC003038; AAD03162.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC004447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC003700; AAH03700.1; -; mRNA.
DR EMBL; BC067125; AAH67125.1; ALT_INIT; mRNA.
DR CCDS; CCDS32965.1; -. [Q6NXE6-2]
DR CCDS; CCDS56089.1; -. [Q6NXE6-1]
DR RefSeq; NP_001186125.1; NM_001199196.1. [Q6NXE6-1]
DR RefSeq; NP_219483.1; NM_033415.3. [Q6NXE6-2]
DR RefSeq; XP_005260214.1; XM_005260157.3. [Q6NXE6-2]
DR RefSeq; XP_016882974.1; XM_017027485.1. [Q6NXE6-2]
DR AlphaFoldDB; Q6NXE6; -.
DR SMR; Q6NXE6; -.
DR BioGRID; 125026; 190.
DR IntAct; Q6NXE6; 65.
DR MINT; Q6NXE6; -.
DR STRING; 9606.ENSP00000444156; -.
DR iPTMnet; Q6NXE6; -.
DR PhosphoSitePlus; Q6NXE6; -.
DR BioMuta; ARMC6; -.
DR DMDM; 109940304; -.
DR EPD; Q6NXE6; -.
DR jPOST; Q6NXE6; -.
DR MassIVE; Q6NXE6; -.
DR MaxQB; Q6NXE6; -.
DR PaxDb; Q6NXE6; -.
DR PeptideAtlas; Q6NXE6; -.
DR PRIDE; Q6NXE6; -.
DR ProteomicsDB; 66751; -. [Q6NXE6-1]
DR ProteomicsDB; 66752; -. [Q6NXE6-2]
DR Antibodypedia; 28329; 112 antibodies from 25 providers.
DR DNASU; 93436; -.
DR Ensembl; ENST00000269932.10; ENSP00000269932.6; ENSG00000105676.14. [Q6NXE6-2]
DR Ensembl; ENST00000392335.6; ENSP00000376147.2; ENSG00000105676.14. [Q6NXE6-2]
DR Ensembl; ENST00000392336.7; ENSP00000376148.3; ENSG00000105676.14. [Q6NXE6-1]
DR Ensembl; ENST00000535612.6; ENSP00000444156.1; ENSG00000105676.14. [Q6NXE6-1]
DR GeneID; 93436; -.
DR KEGG; hsa:93436; -.
DR MANE-Select; ENST00000535612.6; ENSP00000444156.1; NM_001199196.2; NP_001186125.1.
DR UCSC; uc002nlc.4; human. [Q6NXE6-1]
DR CTD; 93436; -.
DR DisGeNET; 93436; -.
DR GeneCards; ARMC6; -.
DR HGNC; HGNC:25049; ARMC6.
DR HPA; ENSG00000105676; Tissue enhanced (liver).
DR neXtProt; NX_Q6NXE6; -.
DR OpenTargets; ENSG00000105676; -.
DR PharmGKB; PA134884604; -.
DR VEuPathDB; HostDB:ENSG00000105676; -.
DR eggNOG; KOG4199; Eukaryota.
DR GeneTree; ENSGT00390000002913; -.
DR HOGENOM; CLU_039447_1_0_1; -.
DR InParanoid; Q6NXE6; -.
DR OMA; QRNGAWA; -.
DR OrthoDB; 605325at2759; -.
DR PhylomeDB; Q6NXE6; -.
DR TreeFam; TF324526; -.
DR PathwayCommons; Q6NXE6; -.
DR SignaLink; Q6NXE6; -.
DR BioGRID-ORCS; 93436; 104 hits in 1075 CRISPR screens.
DR ChiTaRS; ARMC6; human.
DR GeneWiki; ARMC6; -.
DR GenomeRNAi; 93436; -.
DR Pharos; Q6NXE6; Tdark.
DR PRO; PR:Q6NXE6; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6NXE6; protein.
DR Bgee; ENSG00000105676; Expressed in right lobe of liver and 177 other tissues.
DR ExpressionAtlas; Q6NXE6; baseline and differential.
DR Genevisible; Q6NXE6; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR040104; ARMC6.
DR PANTHER; PTHR22895:SF0; PTHR22895:SF0; 1.
DR Pfam; PF00514; Arm; 1.
DR SMART; SM00185; ARM; 6.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Methylation; Phosphoprotein; Reference proteome;
KW Repeat.
FT CHAIN 1..501
FT /note="Armadillo repeat-containing protein 6"
FT /id="PRO_0000242660"
FT REPEAT 220..264
FT /note="ARM 1"
FT REPEAT 274..318
FT /note="ARM 2"
FT REPEAT 319..369
FT /note="ARM 3"
FT REPEAT 370..412
FT /note="ARM 4"
FT MOD_RES 64
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17525332"
FT MOD_RES 263
FT /note="Pros-methylhistidine"
FT /evidence="ECO:0000269|PubMed:33563959"
FT VAR_SEQ 1..25
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_040103"
FT MUTAGEN 261
FT /note="H->R,A: Strongly reduced histidine methylation by
FT METTL9."
FT /evidence="ECO:0000269|PubMed:33563959"
FT MUTAGEN 262
FT /note="A->G: Does not affect histidine methylation by
FT METTL9."
FT /evidence="ECO:0000269|PubMed:33563959"
FT MUTAGEN 263
FT /note="H->R,A: Abolished histidine methylation by METTL9."
FT /evidence="ECO:0000269|PubMed:33563959"
FT MUTAGEN 264
FT /note="N->D: Does not affect histidine methylation by
FT METTL9."
FT /evidence="ECO:0000269|PubMed:33563959"
FT MUTAGEN 265
FT /note="H->A: Does not affect histidine methylation by
FT METTL9."
FT /evidence="ECO:0000269|PubMed:33563959"
FT MUTAGEN 266
FT /note="A->G: Does not affect histidine methylation by
FT METTL9."
FT /evidence="ECO:0000269|PubMed:33563959"
FT MUTAGEN 267
FT /note="K->R: Does not affect histidine methylation by
FT METTL9."
FT /evidence="ECO:0000269|PubMed:33563959"
SQ SEQUENCE 501 AA; 54142 MW; 13813F0B99AF8AFF CRC64;
MSERCCSRYS SGASIGCTPT STQAKMVSKR IAQETFDAAV RENIEEFAMG PEEAVKEAVE
QFESQGVDLS NIVKTAPKVS ADGSQEPTHD ILQMLSDLQE SVASSRPQEV SAYLTRFCDQ
CKQDKACRFL AAQKGAYPII FTAWKLATAG DQGLLLQSLN ALSVLTDGQP DLLDAQGLQL
LVATLTQNAD EADLTCSGIR CVRHACLKHE QNRQDLVKAG VLPLLTGAIT HHGHHTDVVR
EACWALRVMT FDDDIRVPFG HAHNHAKMIV QENKGLKVLI EATKAFLDNP GILSELCGTL
SRLAIRNEFC QEVVDLGGLS ILVSLLADCN DHQMRDQSGV QELVKQVLST LRAIAGNDDV
KDAIVRAGGT ESIVAAMTQH LTSPQVCEQS CAALCFLALR KPDNSRIIVE GGGAVAALQA
MKAHPQKAGV QKQACMLIRN LVAHGQAFSK PILDLGAEAL IMQARSAHRD CEDVAKAALR
DLGCHVELRE LWTGQRGNLA P
