ARMC7_HUMAN
ID ARMC7_HUMAN Reviewed; 198 AA.
AC Q9H6L4; B4DVA4;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Armadillo repeat-containing protein 7;
GN Name=ARMC7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-169, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
CC -!- INTERACTION:
CC Q9H6L4; Q9NYB9: ABI2; NbExp=4; IntAct=EBI-742909, EBI-743598;
CC Q9H6L4; Q9P2A4: ABI3; NbExp=3; IntAct=EBI-742909, EBI-742038;
CC Q9H6L4; Q9H5F2: C11orf1; NbExp=3; IntAct=EBI-742909, EBI-718615;
CC Q9H6L4; Q8NA61: CBY2; NbExp=3; IntAct=EBI-742909, EBI-741724;
CC Q9H6L4; Q9BUN5-3: CCDC28B; NbExp=3; IntAct=EBI-742909, EBI-12920646;
CC Q9H6L4; Q00587-2: CDC42EP1; NbExp=3; IntAct=EBI-742909, EBI-11027409;
CC Q9H6L4; Q9NX63: CHCHD3; NbExp=3; IntAct=EBI-742909, EBI-743375;
CC Q9H6L4; Q16630: CPSF6; NbExp=4; IntAct=EBI-742909, EBI-358410;
CC Q9H6L4; Q16630-2: CPSF6; NbExp=3; IntAct=EBI-742909, EBI-11088043;
CC Q9H6L4; Q8N684: CPSF7; NbExp=3; IntAct=EBI-742909, EBI-746909;
CC Q9H6L4; Q8N684-3: CPSF7; NbExp=3; IntAct=EBI-742909, EBI-11523759;
CC Q9H6L4; Q9NRI5-2: DISC1; NbExp=3; IntAct=EBI-742909, EBI-11988027;
CC Q9H6L4; A0A0U1RQF7: DPEP2NB; NbExp=3; IntAct=EBI-742909, EBI-18398199;
CC Q9H6L4; Q86UW9: DTX2; NbExp=3; IntAct=EBI-742909, EBI-740376;
CC Q9H6L4; Q5JST6: EFHC2; NbExp=3; IntAct=EBI-742909, EBI-2349927;
CC Q9H6L4; Q96DF8: ESS2; NbExp=3; IntAct=EBI-742909, EBI-3928124;
CC Q9H6L4; P15976-2: GATA1; NbExp=3; IntAct=EBI-742909, EBI-9090198;
CC Q9H6L4; O75420: GIGYF1; NbExp=3; IntAct=EBI-742909, EBI-947774;
CC Q9H6L4; O14964: HGS; NbExp=3; IntAct=EBI-742909, EBI-740220;
CC Q9H6L4; P49639: HOXA1; NbExp=3; IntAct=EBI-742909, EBI-740785;
CC Q9H6L4; Q13422: IKZF1; NbExp=3; IntAct=EBI-742909, EBI-745305;
CC Q9H6L4; Q9UKT9: IKZF3; NbExp=9; IntAct=EBI-742909, EBI-747204;
CC Q9H6L4; Q0VD86: INCA1; NbExp=3; IntAct=EBI-742909, EBI-6509505;
CC Q9H6L4; Q8WZ19: KCTD13; NbExp=4; IntAct=EBI-742909, EBI-742916;
CC Q9H6L4; Q15323: KRT31; NbExp=6; IntAct=EBI-742909, EBI-948001;
CC Q9H6L4; O76011: KRT34; NbExp=3; IntAct=EBI-742909, EBI-1047093;
CC Q9H6L4; Q6A163: KRT39; NbExp=3; IntAct=EBI-742909, EBI-11958242;
CC Q9H6L4; Q6A162: KRT40; NbExp=6; IntAct=EBI-742909, EBI-10171697;
CC Q9H6L4; O95678: KRT75; NbExp=3; IntAct=EBI-742909, EBI-2949715;
CC Q9H6L4; Q3SYF9: KRTAP19-7; NbExp=3; IntAct=EBI-742909, EBI-10241353;
CC Q9H6L4; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-742909, EBI-741037;
CC Q9H6L4; Q99750: MDFI; NbExp=3; IntAct=EBI-742909, EBI-724076;
CC Q9H6L4; O00746: NME4; NbExp=3; IntAct=EBI-742909, EBI-744871;
CC Q9H6L4; Q9P286: PAK5; NbExp=3; IntAct=EBI-742909, EBI-741896;
CC Q9H6L4; Q9BSJ6: PIMREG; NbExp=3; IntAct=EBI-742909, EBI-2568609;
CC Q9H6L4; Q58EX7: PLEKHG4; NbExp=3; IntAct=EBI-742909, EBI-949255;
CC Q9H6L4; P0CW24: PNMA6A; NbExp=3; IntAct=EBI-742909, EBI-721270;
CC Q9H6L4; Q5RL73: RBM48; NbExp=5; IntAct=EBI-742909, EBI-473821;
CC Q9H6L4; Q04864-2: REL; NbExp=3; IntAct=EBI-742909, EBI-10829018;
CC Q9H6L4; Q9Y3A4: RRP7A; NbExp=3; IntAct=EBI-742909, EBI-7223720;
CC Q9H6L4; Q59EK9: RUNDC3A; NbExp=3; IntAct=EBI-742909, EBI-747225;
CC Q9H6L4; Q59EK9-3: RUNDC3A; NbExp=3; IntAct=EBI-742909, EBI-11957366;
CC Q9H6L4; Q8IYX7: SAXO1; NbExp=3; IntAct=EBI-742909, EBI-3957636;
CC Q9H6L4; Q6ZU15: SEPTIN14; NbExp=3; IntAct=EBI-742909, EBI-2009297;
CC Q9H6L4; Q6ZSJ9: SHISA6; NbExp=3; IntAct=EBI-742909, EBI-12037847;
CC Q9H6L4; Q8ND83: SLAIN1; NbExp=3; IntAct=EBI-742909, EBI-10269374;
CC Q9H6L4; Q9H0A9: SPATC1L; NbExp=3; IntAct=EBI-742909, EBI-372911;
CC Q9H6L4; Q9H0A9-2: SPATC1L; NbExp=3; IntAct=EBI-742909, EBI-11995806;
CC Q9H6L4; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-742909, EBI-742688;
CC Q9H6L4; O95926: SYF2; NbExp=3; IntAct=EBI-742909, EBI-2557644;
CC Q9H6L4; Q5VWN6: TASOR2; NbExp=3; IntAct=EBI-742909, EBI-745958;
CC Q9H6L4; P15884: TCF4; NbExp=3; IntAct=EBI-742909, EBI-533224;
CC Q9H6L4; Q8NA69: TEX45; NbExp=3; IntAct=EBI-742909, EBI-12021638;
CC Q9H6L4; Q13829: TNFAIP1; NbExp=6; IntAct=EBI-742909, EBI-2505861;
CC Q9H6L4; P19237: TNNI1; NbExp=3; IntAct=EBI-742909, EBI-746692;
CC Q9H6L4; Q96RU7: TRIB3; NbExp=3; IntAct=EBI-742909, EBI-492476;
CC Q9H6L4; P14373: TRIM27; NbExp=6; IntAct=EBI-742909, EBI-719493;
CC Q9H6L4; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-742909, EBI-5235829;
CC Q9H6L4; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-742909, EBI-2130429;
CC Q9H6L4; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-742909, EBI-11975223;
CC Q9H6L4; P08670: VIM; NbExp=3; IntAct=EBI-742909, EBI-353844;
CC Q9H6L4; Q86XT2: VPS37D; NbExp=3; IntAct=EBI-742909, EBI-7604353;
CC Q9H6L4; Q96BR9: ZBTB8A; NbExp=3; IntAct=EBI-742909, EBI-742740;
CC Q9H6L4; Q53FD0-2: ZC2HC1C; NbExp=3; IntAct=EBI-742909, EBI-14104088;
CC Q9H6L4; Q9UDW3: ZMAT5; NbExp=3; IntAct=EBI-742909, EBI-7850213;
CC Q9H6L4; P52738: ZNF140; NbExp=3; IntAct=EBI-742909, EBI-12069140;
CC Q9H6L4; Q9BUY5: ZNF426; NbExp=3; IntAct=EBI-742909, EBI-743265;
CC Q9H6L4; Q96BR6: ZNF669; NbExp=3; IntAct=EBI-742909, EBI-12006574;
CC Q9H6L4; Q96H86: ZNF764; NbExp=3; IntAct=EBI-742909, EBI-745775;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9H6L4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9H6L4-2; Sequence=VSP_056936, VSP_056937;
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DR EMBL; AK025813; BAB15242.1; -; mRNA.
DR EMBL; AK300997; BAG62616.1; -; mRNA.
DR EMBL; AC022211; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC111186; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC011728; AAH11728.1; -; mRNA.
DR CCDS; CCDS11714.1; -. [Q9H6L4-1]
DR CCDS; CCDS77107.1; -. [Q9H6L4-2]
DR RefSeq; NP_001291200.1; NM_001304271.1. [Q9H6L4-2]
DR RefSeq; NP_001291201.1; NM_001304272.1.
DR RefSeq; NP_001291202.1; NM_001304273.1.
DR RefSeq; NP_078861.1; NM_024585.3. [Q9H6L4-1]
DR PDB; 7DVQ; EM; 2.89 A; K=1-198.
DR PDBsum; 7DVQ; -.
DR AlphaFoldDB; Q9H6L4; -.
DR SMR; Q9H6L4; -.
DR BioGRID; 122766; 81.
DR IntAct; Q9H6L4; 104.
DR STRING; 9606.ENSP00000245543; -.
DR iPTMnet; Q9H6L4; -.
DR PhosphoSitePlus; Q9H6L4; -.
DR BioMuta; ARMC7; -.
DR DMDM; 74733612; -.
DR EPD; Q9H6L4; -.
DR jPOST; Q9H6L4; -.
DR MassIVE; Q9H6L4; -.
DR MaxQB; Q9H6L4; -.
DR PaxDb; Q9H6L4; -.
DR PeptideAtlas; Q9H6L4; -.
DR PRIDE; Q9H6L4; -.
DR ProteomicsDB; 81001; -. [Q9H6L4-1]
DR TopDownProteomics; Q9H6L4-1; -. [Q9H6L4-1]
DR Antibodypedia; 19498; 77 antibodies from 20 providers.
DR DNASU; 79637; -.
DR Ensembl; ENST00000245543.6; ENSP00000245543.1; ENSG00000125449.7. [Q9H6L4-1]
DR Ensembl; ENST00000581078.1; ENSP00000462962.1; ENSG00000125449.7. [Q9H6L4-2]
DR GeneID; 79637; -.
DR KEGG; hsa:79637; -.
DR MANE-Select; ENST00000245543.6; ENSP00000245543.1; NM_024585.4; NP_078861.1.
DR UCSC; uc002jmw.1; human. [Q9H6L4-1]
DR CTD; 79637; -.
DR GeneCards; ARMC7; -.
DR HGNC; HGNC:26168; ARMC7.
DR HPA; ENSG00000125449; Low tissue specificity.
DR neXtProt; NX_Q9H6L4; -.
DR OpenTargets; ENSG00000125449; -.
DR PharmGKB; PA134901380; -.
DR VEuPathDB; HostDB:ENSG00000125449; -.
DR eggNOG; KOG4646; Eukaryota.
DR GeneTree; ENSGT00940000162633; -.
DR HOGENOM; CLU_2262837_0_0_1; -.
DR InParanoid; Q9H6L4; -.
DR OMA; GMGGLCN; -.
DR OrthoDB; 1566260at2759; -.
DR PhylomeDB; Q9H6L4; -.
DR TreeFam; TF354322; -.
DR PathwayCommons; Q9H6L4; -.
DR SignaLink; Q9H6L4; -.
DR BioGRID-ORCS; 79637; 725 hits in 1087 CRISPR screens.
DR ChiTaRS; ARMC7; human.
DR GenomeRNAi; 79637; -.
DR Pharos; Q9H6L4; Tdark.
DR PRO; PR:Q9H6L4; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q9H6L4; protein.
DR Bgee; ENSG00000125449; Expressed in triceps brachii and 201 other tissues.
DR ExpressionAtlas; Q9H6L4; baseline and differential.
DR Genevisible; Q9H6L4; HS.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR042462; ARMC7.
DR PANTHER; PTHR46263; PTHR46263; 1.
DR Pfam; PF00514; Arm; 1.
DR SMART; SM00185; ARM; 2.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Phosphoprotein; Reference proteome;
KW Repeat.
FT CHAIN 1..198
FT /note="Armadillo repeat-containing protein 7"
FT /id="PRO_0000242666"
FT REPEAT 57..99
FT /note="ARM 1"
FT REPEAT 100..140
FT /note="ARM 2"
FT MOD_RES 169
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT VAR_SEQ 58..103
FT /note="VLDLFLDSLSEENETLVEFAIGGLCNLCPDRANKEHILHAGGVPLI -> EA
FT CATCAQTGPTRSTSCTQEVSHSSSTAYPAPMRRRCCLPSPRSCT (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056936"
FT VAR_SEQ 104..198
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056937"
FT HELIX 13..26
FT /evidence="ECO:0007829|PDB:7DVQ"
FT HELIX 30..43
FT /evidence="ECO:0007829|PDB:7DVQ"
FT HELIX 49..54
FT /evidence="ECO:0007829|PDB:7DVQ"
FT TURN 55..57
FT /evidence="ECO:0007829|PDB:7DVQ"
FT HELIX 58..67
FT /evidence="ECO:0007829|PDB:7DVQ"
FT HELIX 71..84
FT /evidence="ECO:0007829|PDB:7DVQ"
FT HELIX 88..97
FT /evidence="ECO:0007829|PDB:7DVQ"
FT HELIX 100..104
FT /evidence="ECO:0007829|PDB:7DVQ"
FT HELIX 105..108
FT /evidence="ECO:0007829|PDB:7DVQ"
FT HELIX 112..124
FT /evidence="ECO:0007829|PDB:7DVQ"
FT TURN 128..131
FT /evidence="ECO:0007829|PDB:7DVQ"
FT HELIX 133..138
FT /evidence="ECO:0007829|PDB:7DVQ"
FT HELIX 141..149
FT /evidence="ECO:0007829|PDB:7DVQ"
FT HELIX 154..167
FT /evidence="ECO:0007829|PDB:7DVQ"
FT HELIX 170..185
FT /evidence="ECO:0007829|PDB:7DVQ"
SQ SEQUENCE 198 AA; 21924 MW; B637A76677FE645E CRC64;
MAQKPKVDPH VGRLGYLQAL VTEFQETQSQ DAKEQVLANL ANFAYDPSNY EYLRQLQVLD
LFLDSLSEEN ETLVEFAIGG LCNLCPDRAN KEHILHAGGV PLIINCLSSP NEETVLSAIT
TLMHLSPPGR SFLPELTATP VVQCMLRFSL SASARLRNLA QIFLEDFCSP RQVAEARSRQ
AHSALGIPLP RSVAPRQR
