ID   ARMC8_DANRE             Reviewed;         673 AA.
AC   Q05AL1;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Armadillo repeat-containing protein 8;
GN   Name=armc8; ORFNames=zgc:153683;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the CTLH E3 ubiquitin-protein ligase complex
CC       that mediates ubiquitination and subsequent proteasomal degradation of
CC       target proteins. {ECO:0000250|UniProtKB:Q8IUR7}.
CC   -!- SUBUNIT: Identified in the CTLH complex that contains at least MAEA,
CC       RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9
CC       and/or RANBP10; ARMC8 has an ancillary role in the complex.
CC       {ECO:0000250|UniProtKB:Q8IUR7}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8IUR7}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8IUR7}.
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DR   EMBL; BC124424; AAI24425.1; -; mRNA.
DR   RefSeq; NP_001073151.1; NM_001079683.1.
DR   AlphaFoldDB; Q05AL1; -.
DR   SMR; Q05AL1; -.
DR   STRING; 7955.ENSDARP00000115627; -.
DR   PaxDb; Q05AL1; -.
DR   GeneID; 571528; -.
DR   KEGG; dre:571528; -.
DR   CTD; 25852; -.
DR   ZFIN; ZDB-GENE-061027-88; armc8.
DR   eggNOG; KOG1293; Eukaryota.
DR   InParanoid; Q05AL1; -.
DR   OrthoDB; 1353793at2759; -.
DR   PhylomeDB; Q05AL1; -.
DR   Reactome; R-DRE-6798695; Neutrophil degranulation.
DR   PRO; PR:Q05AL1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0034657; C:GID complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR038739; ARMC8/Vid28.
DR   PANTHER; PTHR15651; PTHR15651; 1.
DR   SMART; SM00185; ARM; 9.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..673
FT                   /note="Armadillo repeat-containing protein 8"
FT                   /id="PRO_0000284412"
FT   REPEAT          51..92
FT                   /note="ARM 1"
FT   REPEAT          95..134
FT                   /note="ARM 2"
FT   REPEAT          138..176
FT                   /note="ARM 3"
FT   REPEAT          178..217
FT                   /note="ARM 4"
FT   REPEAT          225..265
FT                   /note="ARM 5"
FT   REPEAT          269..309
FT                   /note="ARM 6"
FT   REPEAT          313..352
FT                   /note="ARM 7"
FT   REPEAT          374..413
FT                   /note="ARM 8"
FT   REPEAT          416..455
FT                   /note="ARM 9"
FT   REPEAT          458..497
FT                   /note="ARM 10"
FT   REPEAT          501..540
FT                   /note="ARM 11"
FT   REPEAT          543..585
FT                   /note="ARM 12"
FT   REPEAT          588..627
FT                   /note="ARM 13"
FT   REPEAT          634..673
FT                   /note="ARM 14"
SQ   SEQUENCE   673 AA;  75451 MW;  650C64D9E2AA2E78 CRC64;
     MACLLEAPLR ISVLSEVTAT SRHYVDRLFD PDPQNVLQGV IDMKNAVIGN NKQKANLIVL
     GAVPRLLYLL QQSSSTLELR TECAVVLGSL SMGTENNIKS LVDCHIIPAL LQGLLCSDLI
     FIEACLRCLR TVFISPVTPV QLLYTDPTVI PHLMSLLSRS QHTQEYITQI FAHCCKTPEH
     QTVLFNHGAI QNIAPLLISP SYKVRMQALK CFSVLAYENA QVSMTLVNVL VDGEQLSQVF
     VRMMQRDKPI EMQLTAAKCL TYMCRAGAIR TEDNCIVLKT LPCLVRMCSK ERLLEERVEG
     AETLAYLMEP DIELQRIASV TDHLVSMLAD YFKYPSSVSA ITDIKRLDHD LKHAHELRQA
     AFKLYASLGS NDEDIRKKIT ETENMMDRIV SGLSESSIKV RLAAVRCLHS LSRSVQQLRT
     SFHDHAVWKP LMKLLQNAPD EVLVMASSTL CNLLLEFSPS KEPILESGVI ELLCSLTQSD
     SSALRVNGIW ALMNMAFQAD QKVKVEIVRA LGTEQLFRLL SDPDTNVLMK TLGLLRNLLS
     TRPHIDQIMS SHGKQIMQAV TLILEGEHSI EVKEQTLCIL ANIADGNTAK ELIMTDDDML
     QKIKYYMGHS NVKLQLAATF CISNLIWNEE DGSQERQDKL REMGFVDILH KLTQASDPDL
     CDRAKTAMQQ YLA