ARMC8_HUMAN
ID ARMC8_HUMAN Reviewed; 673 AA.
AC Q8IUR7; A8K0L2; B7Z441; B7Z453; D3DNE6; F5GWK4; Q6PIL2; Q96D19; Q96HZ5;
AC Q9NV02; Q9NV94; Q9Y4R9;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Armadillo repeat-containing protein 8;
GN Name=ARMC8; ORFNames=S863-2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6).
RC TISSUE=Aorta;
RA Liu B., Zhao B., Wang X.Y., Xu Y.Y., Liu Y.Q., Song L., Ye J., Sheng H.,
RA Gao Y., Zhang C.L., Wei Y.J., Zhang J., Song L., Jiang Y.X., Zhao Z.W.,
RA Ding J.F., Liu L.S., Gao R.L., Wu Q.Y., Qiang B.Q., Yuan J.G., Liew C.C.,
RA Zhao M.S., Hui R.T.;
RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 6; 7 AND 8), AND
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 243-673 (ISOFORMS 1/2/3).
RC TISSUE=Cerebellum, Placenta, Teratocarcinoma, and Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 6).
RC TISSUE=Brain, Lung, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PROTEIN SEQUENCE OF 2-22; 36-44; 55-65; 247-258; 364-376; 379-399; 510-530;
RP 591-602 AND 642-651, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT
RP ALA-2, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Ovarian carcinoma;
RA Bienvenut W.V., Lempens A., Norman J.C.;
RL Submitted (OCT-2009) to UniProtKB.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 432-673 (ISOFORMS 1/2/3).
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [8]
RP IDENTIFICATION IN THE CTLH COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY,
RP AND SUBCELLULAR LOCATION.
RX PubMed=17467196; DOI=10.1016/j.gene.2007.02.032;
RA Kobayashi N., Yang J., Ueda A., Suzuki T., Tomaru K., Takeno M., Okuda K.,
RA Ishigatsubo Y.;
RT "RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins
RT ARMC8alpha and ARMC8beta are components of the CTLH complex.";
RL Gene 396:236-247(2007).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-337 AND SER-512, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [11]
RP FUNCTION, IDENTIFICATION IN THE CTLH COMPLEX, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=29911972; DOI=10.7554/elife.35528;
RA Lampert F., Stafa D., Goga A., Soste M.V., Gilberto S., Olieric N.,
RA Picotti P., Stoffel M., Peter M.;
RT "The multi-subunit GID/CTLH E3 ligase promotes proliferation and targets
RT the transcription factor Hbp1 for degradation.";
RL Elife 7:0-0(2018).
CC -!- FUNCTION: Component of the CTLH E3 ubiquitin-protein ligase complex
CC that selectively accepts ubiquitin from UBE2H and mediates
CC ubiquitination and subsequent proteasomal degradation of the
CC transcription factor HBP1. {ECO:0000269|PubMed:29911972}.
CC -!- SUBUNIT: Identified in the CTLH complex that contains GID4, RANBP9
CC and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog
CC RMND5B), GID8, ARMC8, WDR26 and YPEL5 (PubMed:17467196,
CC PubMed:29911972). Within this complex, MAEA, RMND5A (or alternatively
CC its paralog RMND5B), GID8, WDR26, and RANBP9 and/or RANBP10 form the
CC catalytic core, while GID4, MKLN1, ARMC8 and YPEL5 have ancillary roles
CC (PubMed:29911972). {ECO:0000269|PubMed:17467196,
CC ECO:0000269|PubMed:29911972}.
CC -!- INTERACTION:
CC Q8IUR7; Q99081: TCF12; NbExp=3; IntAct=EBI-1049469, EBI-722877;
CC Q8IUR7-6; Q96Q77: CIB3; NbExp=3; IntAct=EBI-11942961, EBI-10292696;
CC Q8IUR7-6; Q9NWU2: GID8; NbExp=4; IntAct=EBI-11942961, EBI-1051077;
CC Q8IUR7-6; O43752: STX6; NbExp=3; IntAct=EBI-11942961, EBI-2695795;
CC Q8IUR7-6; Q9H0C1: ZMYND12; NbExp=3; IntAct=EBI-11942961, EBI-12030590;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17467196}. Cytoplasm
CC {ECO:0000269|PubMed:17467196}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q8IUR7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IUR7-2; Sequence=VSP_024509;
CC Name=3;
CC IsoId=Q8IUR7-3; Sequence=VSP_024512;
CC Name=6;
CC IsoId=Q8IUR7-6; Sequence=VSP_024509, VSP_024513, VSP_024514;
CC Name=7;
CC IsoId=Q8IUR7-7; Sequence=VSP_044774;
CC Name=8;
CC IsoId=Q8IUR7-8; Sequence=VSP_045137;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA91861.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAA91959.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC Sequence=CAB46423.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF109184; AAQ13493.1; -; mRNA.
DR EMBL; AK001721; BAA91861.1; ALT_FRAME; mRNA.
DR EMBL; AK001882; BAA91959.1; ALT_SEQ; mRNA.
DR EMBL; AK289577; BAF82266.1; -; mRNA.
DR EMBL; AK296757; BAH12427.1; -; mRNA.
DR EMBL; AK296837; BAH12439.1; -; mRNA.
DR EMBL; AC022337; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC068777; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471052; EAW79076.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW79075.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW79079.1; -; Genomic_DNA.
DR EMBL; BC013424; AAH13424.1; -; mRNA.
DR EMBL; BC032661; AAH32661.1; -; mRNA.
DR EMBL; BC041699; AAH41699.1; -; mRNA.
DR EMBL; AL096748; CAB46423.1; ALT_SEQ; mRNA.
DR CCDS; CCDS3098.1; -. [Q8IUR7-6]
DR CCDS; CCDS54646.1; -. [Q8IUR7-2]
DR CCDS; CCDS58853.1; -. [Q8IUR7-8]
DR CCDS; CCDS58854.1; -. [Q8IUR7-7]
DR CCDS; CCDS87139.1; -. [Q8IUR7-1]
DR CCDS; CCDS87140.1; -. [Q8IUR7-3]
DR PIR; T12513; T12513.
DR RefSeq; NP_001253970.1; NM_001267041.2. [Q8IUR7-7]
DR RefSeq; NP_001253971.1; NM_001267042.2. [Q8IUR7-8]
DR RefSeq; NP_001269271.1; NM_001282342.1.
DR RefSeq; NP_054873.2; NM_014154.4. [Q8IUR7-6]
DR RefSeq; NP_056211.2; NM_015396.5. [Q8IUR7-2]
DR RefSeq; NP_998819.1; NM_213654.3. [Q8IUR7-6]
DR RefSeq; XP_006713627.1; XM_006713564.3.
DR RefSeq; XP_006713628.1; XM_006713565.2. [Q8IUR7-2]
DR RefSeq; XP_006713629.1; XM_006713566.3. [Q8IUR7-3]
DR RefSeq; XP_011510934.1; XM_011512632.1. [Q8IUR7-3]
DR RefSeq; XP_011510935.1; XM_011512633.1.
DR PDB; 7NSC; EM; 3.30 A; E=16-673.
DR PDBsum; 7NSC; -.
DR AlphaFoldDB; Q8IUR7; -.
DR SMR; Q8IUR7; -.
DR BioGRID; 117376; 243.
DR CORUM; Q8IUR7; -.
DR IntAct; Q8IUR7; 73.
DR MINT; Q8IUR7; -.
DR STRING; 9606.ENSP00000420333; -.
DR GlyGen; Q8IUR7; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8IUR7; -.
DR PhosphoSitePlus; Q8IUR7; -.
DR BioMuta; ARMC8; -.
DR DMDM; 145558852; -.
DR EPD; Q8IUR7; -.
DR jPOST; Q8IUR7; -.
DR MassIVE; Q8IUR7; -.
DR MaxQB; Q8IUR7; -.
DR PaxDb; Q8IUR7; -.
DR PeptideAtlas; Q8IUR7; -.
DR PRIDE; Q8IUR7; -.
DR ProteomicsDB; 24142; -.
DR ProteomicsDB; 6568; -.
DR ProteomicsDB; 70607; -. [Q8IUR7-1]
DR ProteomicsDB; 70608; -. [Q8IUR7-2]
DR ProteomicsDB; 70609; -. [Q8IUR7-3]
DR ProteomicsDB; 70610; -. [Q8IUR7-6]
DR Antibodypedia; 33425; 148 antibodies from 21 providers.
DR DNASU; 25852; -.
DR Ensembl; ENST00000358441.6; ENSP00000351221.2; ENSG00000114098.18. [Q8IUR7-6]
DR Ensembl; ENST00000461822.5; ENSP00000420706.1; ENSG00000114098.18. [Q8IUR7-8]
DR Ensembl; ENST00000469044.6; ENSP00000419413.1; ENSG00000114098.18. [Q8IUR7-1]
DR Ensembl; ENST00000471453.5; ENSP00000420440.1; ENSG00000114098.18. [Q8IUR7-6]
DR Ensembl; ENST00000481646.5; ENSP00000420333.1; ENSG00000114098.18. [Q8IUR7-2]
DR Ensembl; ENST00000491704.5; ENSP00000417304.1; ENSG00000114098.18. [Q8IUR7-3]
DR Ensembl; ENST00000538260.5; ENSP00000441592.1; ENSG00000114098.18. [Q8IUR7-7]
DR GeneID; 25852; -.
DR KEGG; hsa:25852; -.
DR MANE-Select; ENST00000469044.6; ENSP00000419413.1; NM_001363941.2; NP_001350870.1.
DR UCSC; uc003erw.6; human. [Q8IUR7-1]
DR CTD; 25852; -.
DR DisGeNET; 25852; -.
DR GeneCards; ARMC8; -.
DR HGNC; HGNC:24999; ARMC8.
DR HPA; ENSG00000114098; Low tissue specificity.
DR MIM; 618521; gene.
DR neXtProt; NX_Q8IUR7; -.
DR OpenTargets; ENSG00000114098; -.
DR PharmGKB; PA134984953; -.
DR VEuPathDB; HostDB:ENSG00000114098; -.
DR eggNOG; KOG1293; Eukaryota.
DR GeneTree; ENSGT00390000003033; -.
DR HOGENOM; CLU_776045_0_0_1; -.
DR InParanoid; Q8IUR7; -.
DR OMA; AKGTDQH; -.
DR OrthoDB; 1353793at2759; -.
DR PhylomeDB; Q8IUR7; -.
DR TreeFam; TF324806; -.
DR PathwayCommons; Q8IUR7; -.
DR Reactome; R-HSA-6798695; Neutrophil degranulation.
DR SignaLink; Q8IUR7; -.
DR BioGRID-ORCS; 25852; 10 hits in 1078 CRISPR screens.
DR ChiTaRS; ARMC8; human.
DR GenomeRNAi; 25852; -.
DR Pharos; Q8IUR7; Tbio.
DR PRO; PR:Q8IUR7; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q8IUR7; protein.
DR Bgee; ENSG00000114098; Expressed in oocyte and 196 other tissues.
DR ExpressionAtlas; Q8IUR7; baseline and differential.
DR Genevisible; Q8IUR7; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0034657; C:GID complex; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0035580; C:specific granule lumen; TAS:Reactome.
DR GO; GO:1904724; C:tertiary granule lumen; TAS:Reactome.
DR GO; GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR038739; ARMC8/Vid28.
DR PANTHER; PTHR15651; PTHR15651; 1.
DR Pfam; PF00514; Arm; 1.
DR SMART; SM00185; ARM; 9.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Alternative splicing; Cytoplasm;
KW Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|Ref.6"
FT CHAIN 2..673
FT /note="Armadillo repeat-containing protein 8"
FT /id="PRO_0000284408"
FT REPEAT 51..92
FT /note="ARM 1"
FT REPEAT 95..134
FT /note="ARM 2"
FT REPEAT 138..176
FT /note="ARM 3"
FT REPEAT 178..217
FT /note="ARM 4"
FT REPEAT 224..265
FT /note="ARM 5"
FT REPEAT 269..309
FT /note="ARM 6"
FT REPEAT 313..352
FT /note="ARM 7"
FT REPEAT 374..413
FT /note="ARM 8"
FT REPEAT 416..455
FT /note="ARM 9"
FT REPEAT 458..497
FT /note="ARM 10"
FT REPEAT 501..540
FT /note="ARM 11"
FT REPEAT 543..585
FT /note="ARM 12"
FT REPEAT 588..627
FT /note="ARM 13"
FT REPEAT 634..673
FT /note="ARM 14"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000269|Ref.6"
FT MOD_RES 337
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 512
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..42
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_024512"
FT VAR_SEQ 2..15
FT /note="Missing (in isoform 2 and isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT /id="VSP_024509"
FT VAR_SEQ 146..176
FT /note="Missing (in isoform 7)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044774"
FT VAR_SEQ 280..346
FT /note="Missing (in isoform 8)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045137"
FT VAR_SEQ 379..399
FT /note="IIETENMMDRIVTGLSESSVK -> VSLGEGRPPVLTASRQGVTST (in
FT isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT /id="VSP_024513"
FT VAR_SEQ 400..673
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334, ECO:0000303|Ref.1"
FT /id="VSP_024514"
FT CONFLICT 78
FT /note="E -> G (in Ref. 2; BAA91861)"
FT /evidence="ECO:0000305"
FT CONFLICT 128
FT /note="C -> R (in Ref. 2; BAH12439)"
FT /evidence="ECO:0000305"
FT CONFLICT 231
FT /note="V -> A (in Ref. 5; AAH32661)"
FT /evidence="ECO:0000305"
FT CONFLICT 327
FT /note="M -> V (in Ref. 2; BAA91861)"
FT /evidence="ECO:0000305"
FT CONFLICT 397
FT /note="S -> N (in Ref. 2; BAA91959)"
FT /evidence="ECO:0000305"
FT CONFLICT 462
FT /note="E -> G (in Ref. 2; BAH12439)"
FT /evidence="ECO:0000305"
FT CONFLICT 495
FT /note="M -> I (in Ref. 2; BAH12439)"
FT /evidence="ECO:0000305"
FT CONFLICT 537
FT /note="N -> S (in Ref. 2; BAA91959)"
FT /evidence="ECO:0000305"
FT HELIX 35..47
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 51..56
FT /evidence="ECO:0007829|PDB:7NSC"
FT STRAND 73..75
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 77..91
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 96..102
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 107..113
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 119..134
FT /evidence="ECO:0007829|PDB:7NSC"
FT STRAND 135..138
FT /evidence="ECO:0007829|PDB:7NSC"
FT STRAND 140..146
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 149..157
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 161..174
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 178..186
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 189..193
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 202..215
FT /evidence="ECO:0007829|PDB:7NSC"
FT STRAND 216..218
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 220..226
FT /evidence="ECO:0007829|PDB:7NSC"
FT STRAND 231..234
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 236..242
FT /evidence="ECO:0007829|PDB:7NSC"
FT STRAND 245..248
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 250..266
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 274..277
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 280..287
FT /evidence="ECO:0007829|PDB:7NSC"
FT STRAND 288..292
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 294..307
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 313..320
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 324..329
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 348..352
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 354..368
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 374..381
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 386..393
FT /evidence="ECO:0007829|PDB:7NSC"
FT STRAND 394..396
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 398..411
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 415..424
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 428..436
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 440..453
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 462..465
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 469..475
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 482..495
FT /evidence="ECO:0007829|PDB:7NSC"
FT TURN 496..498
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 501..510
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 513..520
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 525..537
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 542..549
FT /evidence="ECO:0007829|PDB:7NSC"
FT TURN 553..555
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 556..565
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 570..584
FT /evidence="ECO:0007829|PDB:7NSC"
FT STRAND 586..588
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 589..594
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 597..606
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 612..625
FT /evidence="ECO:0007829|PDB:7NSC"
FT STRAND 628..631
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 633..641
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 646..653
FT /evidence="ECO:0007829|PDB:7NSC"
FT HELIX 658..669
FT /evidence="ECO:0007829|PDB:7NSC"
SQ SEQUENCE 673 AA; 75509 MW; 726BAC0A373485E8 CRC64;
MACLLETPIR MSVLSEVTAS SRHYVDRLFD PDPQKVLQGV IDMKNAVIGN NKQKANLIVL
GAVPRLLYLL QQETSSTELK TECAVVLGSL AMGTENNVKS LLDCHIIPAL LQGLLSPDLK
FIEACLRCLR TIFTSPVTPE ELLYTDATVI PHLMALLSRS RYTQEYICQI FSHCCKGPDH
QTILFNHGAV QNIAHLLTSL SYKVRMQALK CFSVLAFENP QVSMTLVNVL VDGELLPQIF
VKMLQRDKPI EMQLTSAKCL TYMCRAGAIR TDDNCIVLKT LPCLVRMCSK ERLLEERVEG
AETLAYLIEP DVELQRIASI TDHLIAMLAD YFKYPSSVSA ITDIKRLDHD LKHAHELRQA
AFKLYASLGA NDEDIRKKII ETENMMDRIV TGLSESSVKV RLAAVRCLHS LSRSVQQLRT
SFQDHAVWKP LMKVLQNAPD EILVVASSML CNLLLEFSPS KEPILESGAV ELLCGLTQSE
NPALRVNGIW ALMNMAFQAE QKIKADILRS LSTEQLFRLL SDSDLNVLMK TLGLLRNLLS
TRPHIDKIMS THGKQIMQAV TLILEGEHNI EVKEQTLCIL ANIADGTTAK DLIMTNDDIL
QKIKYYMGHS HVKLQLAAMF CISNLIWNEE EGSQERQDKL RDMGIVDILH KLSQSPDSNL
CDKAKMALQQ YLA
