ARMC8_MOUSE
ID ARMC8_MOUSE Reviewed; 673 AA.
AC Q9DBR3; Q8BGV2; Q8BUP3;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Armadillo repeat-containing protein 8;
GN Name=Armc8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=C57BL/6J; TISSUE=Hippocampus, Lung, and Olfactory bulb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, Kidney, Liver, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Component of the CTLH E3 ubiquitin-protein ligase complex
CC that selectively accepts ubiquitin from UBE2H and mediates
CC ubiquitination and subsequent proteasomal degradation of the
CC transcription factor HBP1. {ECO:0000250|UniProtKB:Q8IUR7}.
CC -!- SUBUNIT: Identified in the CTLH complex that contains GID4, RANBP9
CC and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog
CC RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA,
CC RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9
CC and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and
CC YPEL5 have ancillary roles. {ECO:0000250|UniProtKB:Q8IUR7}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8IUR7}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q8IUR7}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9DBR3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9DBR3-2; Sequence=VSP_024516, VSP_024517;
CC Name=3;
CC IsoId=Q9DBR3-3; Sequence=VSP_024515, VSP_024516, VSP_024517;
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DR EMBL; AK004793; BAB23569.2; -; mRNA.
DR EMBL; AK078280; BAC37201.1; -; mRNA.
DR EMBL; AK083094; BAC38759.1; -; mRNA.
DR EMBL; BC038866; AAH38866.1; -; mRNA.
DR CCDS; CCDS23434.1; -. [Q9DBR3-1]
DR CCDS; CCDS81059.1; -. [Q9DBR3-2]
DR RefSeq; NP_001159610.1; NM_001166138.1. [Q9DBR3-2]
DR RefSeq; NP_083044.2; NM_028768.3.
DR AlphaFoldDB; Q9DBR3; -.
DR SMR; Q9DBR3; -.
DR BioGRID; 216510; 9.
DR IntAct; Q9DBR3; 2.
DR STRING; 10090.ENSMUSP00000035043; -.
DR iPTMnet; Q9DBR3; -.
DR PhosphoSitePlus; Q9DBR3; -.
DR EPD; Q9DBR3; -.
DR MaxQB; Q9DBR3; -.
DR PaxDb; Q9DBR3; -.
DR PeptideAtlas; Q9DBR3; -.
DR PRIDE; Q9DBR3; -.
DR ProteomicsDB; 283226; -. [Q9DBR3-1]
DR ProteomicsDB; 283227; -. [Q9DBR3-2]
DR ProteomicsDB; 283228; -. [Q9DBR3-3]
DR Antibodypedia; 33425; 148 antibodies from 21 providers.
DR Ensembl; ENSMUST00000185524; ENSMUSP00000139973; ENSMUSG00000032468. [Q9DBR3-2]
DR Ensembl; ENSMUST00000186049; ENSMUSP00000140426; ENSMUSG00000032468. [Q9DBR3-3]
DR GeneID; 74125; -.
DR KEGG; mmu:74125; -.
DR UCSC; uc009reg.1; mouse. [Q9DBR3-2]
DR UCSC; uc009reh.1; mouse. [Q9DBR3-3]
DR CTD; 25852; -.
DR MGI; MGI:1921375; Armc8.
DR VEuPathDB; HostDB:ENSMUSG00000032468; -.
DR eggNOG; KOG1293; Eukaryota.
DR GeneTree; ENSGT00390000003033; -.
DR HOGENOM; CLU_776045_0_0_1; -.
DR InParanoid; Q9DBR3; -.
DR OrthoDB; 1353793at2759; -.
DR PhylomeDB; Q9DBR3; -.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 74125; 4 hits in 74 CRISPR screens.
DR ChiTaRS; Armc8; mouse.
DR PRO; PR:Q9DBR3; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q9DBR3; protein.
DR Bgee; ENSMUSG00000032468; Expressed in ciliary body and 217 other tissues.
DR ExpressionAtlas; Q9DBR3; baseline and differential.
DR Genevisible; Q9DBR3; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0034657; C:GID complex; IBA:GO_Central.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR038739; ARMC8/Vid28.
DR PANTHER; PTHR15651; PTHR15651; 1.
DR Pfam; PF00514; Arm; 1.
DR SMART; SM00185; ARM; 9.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Cytoplasm; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q8IUR7"
FT CHAIN 2..673
FT /note="Armadillo repeat-containing protein 8"
FT /id="PRO_0000284410"
FT REPEAT 51..92
FT /note="ARM 1"
FT REPEAT 95..134
FT /note="ARM 2"
FT REPEAT 138..176
FT /note="ARM 3"
FT REPEAT 178..217
FT /note="ARM 4"
FT REPEAT 224..265
FT /note="ARM 5"
FT REPEAT 269..309
FT /note="ARM 6"
FT REPEAT 313..352
FT /note="ARM 7"
FT REPEAT 374..413
FT /note="ARM 8"
FT REPEAT 416..455
FT /note="ARM 9"
FT REPEAT 458..497
FT /note="ARM 10"
FT REPEAT 501..540
FT /note="ARM 11"
FT REPEAT 543..585
FT /note="ARM 12"
FT REPEAT 588..627
FT /note="ARM 13"
FT REPEAT 634..673
FT /note="ARM 14"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q8IUR7"
FT MOD_RES 337
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IUR7"
FT MOD_RES 512
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IUR7"
FT VAR_SEQ 1..42
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_024515"
FT VAR_SEQ 379..399
FT /note="IIETETMMDRIVTGSSESSVK -> VSLGEGRPPVLTASRQGVTST (in
FT isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_024516"
FT VAR_SEQ 400..673
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_024517"
SQ SEQUENCE 673 AA; 75364 MW; D27B076B7444ACB1 CRC64;
MACLLETPIR MSVLSEVTAS SRHYVDRLFD PDPQKVLQGV IDMKNAVIGN NKQKANLIVL
GAVPRLLYLL QQETSSTELK TECAVVLGSL AMGTENNVKS LLDCHIIPAL LQGLLSPDLK
FIEACLRCLR TIFTSPVTPE ELLYTDATVI PHLMALLSRS RYTQEYICQI FSHCCKGPDH
QTILFNHGAV QNIAHLLTSP SYKVRMQALK CFSVLAFENP QVSMTLVNVL VDGELLPQIF
VKMLQRDKPI EMQLTSAKCL TYMCRAGAIR TDDSCIVLKT LPCLVRMCSK ERLLEERVEG
AETLAYLIEP DVELQRIASI TDHLIAMLAD YFKYPSSVSA ITDIKRLDHD LKHAHELRQA
AFKLYASLGA NDEDIRKKII ETETMMDRIV TGSSESSVKV RLAAVRCLHS LSRSVQQLRT
SFQDHAVWKP LMKVLQNAPD EILVVASSML CNLLLEFSPS KEPILESGAV ELLCGLTQSE
NPALRVNGIW ALMNMAFQAE QKIKADILRS LSTEQLFRLL SDSDMNVLMK TLGLLRNLLS
TRPHIDKIMS THGKQIMQAV TLILEGEHSI EVKEQTLCIL ANIADGTTAK ELIMTNDDIL
QKIKYYMGHS HVKLQLAAMF CISNLTWNEE EGSQERQDKL RDMGIVDILH KLSQSADSNL
CDKAKTALQQ YLA
