ID   ARMC8_PONAB             Reviewed;         673 AA.
AC   Q5R6S3;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Armadillo repeat-containing protein 8;
GN   Name=ARMC8;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the CTLH E3 ubiquitin-protein ligase complex
CC       that selectively accepts ubiquitin from UBE2H and mediates
CC       ubiquitination and subsequent proteasomal degradation of the
CC       transcription factor HBP1. {ECO:0000250|UniProtKB:Q8IUR7}.
CC   -!- SUBUNIT: Identified in the CTLH complex that contains GID4, RANBP9
CC       and/or RANBP10, MKLN1, MAEA, RMND5A (or alternatively its paralog
CC       RMND5B), GID8, ARMC8, WDR26 and YPEL5. Within this complex, MAEA,
CC       RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9
CC       and/or RANBP10 form the catalytic core, while GID4, MKLN1, ARMC8 and
CC       YPEL5 have ancillary roles. {ECO:0000250|UniProtKB:Q8IUR7}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8IUR7}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8IUR7}.
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DR   EMBL; CR860412; CAH92537.1; -; mRNA.
DR   RefSeq; NP_001126485.1; NM_001133013.1.
DR   AlphaFoldDB; Q5R6S3; -.
DR   SMR; Q5R6S3; -.
DR   STRING; 9601.ENSPPYP00000015819; -.
DR   GeneID; 100173472; -.
DR   KEGG; pon:100173472; -.
DR   CTD; 25852; -.
DR   eggNOG; KOG1293; Eukaryota.
DR   InParanoid; Q5R6S3; -.
DR   OrthoDB; 1353793at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR038739; ARMC8/Vid28.
DR   PANTHER; PTHR15651; PTHR15651; 1.
DR   Pfam; PF00514; Arm; 1.
DR   SMART; SM00185; ARM; 9.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome;
KW   Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IUR7"
FT   CHAIN           2..673
FT                   /note="Armadillo repeat-containing protein 8"
FT                   /id="PRO_0000284411"
FT   REPEAT          51..92
FT                   /note="ARM 1"
FT   REPEAT          95..134
FT                   /note="ARM 2"
FT   REPEAT          138..176
FT                   /note="ARM 3"
FT   REPEAT          178..217
FT                   /note="ARM 4"
FT   REPEAT          224..265
FT                   /note="ARM 5"
FT   REPEAT          269..309
FT                   /note="ARM 6"
FT   REPEAT          313..352
FT                   /note="ARM 7"
FT   REPEAT          374..413
FT                   /note="ARM 8"
FT   REPEAT          416..455
FT                   /note="ARM 9"
FT   REPEAT          458..497
FT                   /note="ARM 10"
FT   REPEAT          501..540
FT                   /note="ARM 11"
FT   REPEAT          543..585
FT                   /note="ARM 12"
FT   REPEAT          588..627
FT                   /note="ARM 13"
FT   REPEAT          634..673
FT                   /note="ARM 14"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IUR7"
FT   MOD_RES         337
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IUR7"
FT   MOD_RES         512
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IUR7"
SQ   SEQUENCE   673 AA;  75463 MW;  F5A09F77C738DA20 CRC64;
     MACLLETPIR MSVLSEVTAS SRHYVDRLFD PDPQKVLQGV IDMKNAVIGN NKQKANLIVL
     GAVPRLLYLL QQETSSTELK TECAVVLGSL AMGTENNVKS LLDCHIIPAL LQGLLSPDLK
     FIEACLRCPR TIFTSPVTPE ELLYTDATVI PHLMALLSRS RYTQEYICQI FSHCCKGPDH
     QTILFNHGAV QNIAHLLTSL SYKVRMQALK CFSVLAFENP QVSMTLVNVL VDGELLPQIF
     VKMLQRDKPI EMQLTSAKCL TYMCRAGAIR TDDNCIVLKT LPCLVRMCSK ERLLEERVEG
     AETLAYLIEP DVELQRIASI TDHLIAMLAD YFKYPSSVSA ITDIKRLDHD LKHAHELRQA
     AFKLYASLGA NDEDIRKKII ETENMMDRIV TGLSESSVKV RLAAVRCLHS LSRSVQQLRT
     SFQDHAVWKP LMKVLQNAPD EILVVASSML CNLLLEFSPS KEPILESGAV ELLCGLTQSE
     NPALRVNGIW ALMNTAFQAE QKIKADILRS LSTEQLFRLL SDSDLNVLMK TLGLLRNLLS
     TRPHIDKIMS THGKQIMQAV TLILEGEHNI EVKEQTLCIL ANIADGTTAK DLIMTNDDIL
     QKIKYYMGHS HVKLQLAAMF CISNLIWNEE EGSQERQDKL RDMGIVDILH KLSQSPDSNL
     CDKAKMALQQ YLA