ID   ARMC8_XENLA             Reviewed;         720 AA.
AC   Q68FK4;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Armadillo repeat-containing protein 8;
GN   Name=armc8;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the CTLH E3 ubiquitin-protein ligase complex
CC       that mediates ubiquitination and subsequent proteasomal degradation of
CC       target proteins. {ECO:0000250|UniProtKB:Q8IUR7}.
CC   -!- SUBUNIT: Identified in the CTLH complex that contains at least MAEA,
CC       RMND5A (or alternatively its paralog RMND5B), GID8, WDR26, and RANBP9
CC       and/or RANBP10; ARMC8 has an ancillary role in the complex.
CC       {ECO:0000250|UniProtKB:Q8IUR7}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8IUR7}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q8IUR7}.
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DR   EMBL; BC079724; AAH79724.1; -; mRNA.
DR   RefSeq; NP_001090243.1; NM_001096774.1.
DR   AlphaFoldDB; Q68FK4; -.
DR   SMR; Q68FK4; -.
DR   MaxQB; Q68FK4; -.
DR   DNASU; 779148; -.
DR   GeneID; 779148; -.
DR   CTD; 779148; -.
DR   Xenbase; XB-GENE-866242; armc8.L.
DR   Proteomes; UP000186698; Genome assembly.
DR   Bgee; 779148; Expressed in muscle tissue and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
DR   Gene3D; 1.25.10.10; -; 3.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR038739; ARMC8/Vid28.
DR   PANTHER; PTHR15651; PTHR15651; 1.
DR   Pfam; PF00514; Arm; 1.
DR   SMART; SM00185; ARM; 8.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50176; ARM_REPEAT; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..720
FT                   /note="Armadillo repeat-containing protein 8"
FT                   /id="PRO_0000284413"
FT   REPEAT          51..92
FT                   /note="ARM 1"
FT   REPEAT          95..134
FT                   /note="ARM 2"
FT   REPEAT          138..176
FT                   /note="ARM 3"
FT   REPEAT          178..217
FT                   /note="ARM 4"
FT   REPEAT          224..265
FT                   /note="ARM 5"
FT   REPEAT          269..309
FT                   /note="ARM 6"
FT   REPEAT          313..352
FT                   /note="ARM 7"
FT   REPEAT          421..460
FT                   /note="ARM 8"
FT   REPEAT          463..502
FT                   /note="ARM 9"
FT   REPEAT          505..544
FT                   /note="ARM 10"
FT   REPEAT          548..587
FT                   /note="ARM 11"
FT   REPEAT          590..632
FT                   /note="ARM 12"
FT   REPEAT          635..674
FT                   /note="ARM 13"
FT   REPEAT          681..720
FT                   /note="ARM 14"
SQ   SEQUENCE   720 AA;  80400 MW;  862BFB444D148FE1 CRC64;
     MACVLEPPLR MSVLSEVTAS SRHYVDRLFD PDPQKVLQGV IDMKNAVIGN NKQKANLIVL
     GAVPRLLYLL QQETSSTELK TECAVVLGSL SMGTENNVKS LLDCNIIPAL LQGLLSSDLQ
     FIEACLRCLR TVFTSPVTPV ELLYTDASVI PHLMLLLSRS IYAQEYICQI YAHCCKGPDH
     QTILFNHGVV QNIAHLLTSV SYKVRMQALK CFSVLAFDNP QVSMTLANVL VDGELLPQIF
     AKMLQRDKPI EMQLTAAKCL TYMCRAGSIR TDDNCIVLKT LPCLVRMCSK ERLLEVRVEG
     AETLAYLIEP DVELQRIASI TDHLISMLAD YFKYPSSVSA ITDIKRHQET GQPCIDPEEA
     EPRGTRDESQ CTALSISHPV SQIQHDCLLT SEELDHDLKH AHELRQAAFK LYASLGANDE
     DIRKKIIEAE HMMDRIVNGL SETSVKVRLA AVRCLHSLSR SVQQLRTSFQ DHAVWKPLMK
     VLQNAPDDIL VVASSTLCNL LLEFSPSKEP ILESGAVELL CSLTLSENPA LRVNGIWALM
     NMAFQADQKI KSDILRGLST EQLFQLLSDS DVNVLMKTLG LLRNLLSTRP HIDQIMSTHG
     KQIMQAVTFI LEGEHNIEVK EQTLCILANI ADGTTAKDLI MTNDDILQKI KYYVGHSNLK
     LQLAAMFCIA NLTWNEEEGS QERQDKLREI GIVDILHKLS QSTDPNLCDK AKTALQQYFA