ID   ARMC9_PONAB             Reviewed;         665 AA.
AC   Q5R629;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=LisH domain-containing protein ARMC9;
GN   Name=ARMC9;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in ciliogenesis. It is required for appropriate
CC       acetylation and polyglutamylation of ciliary microtubules, and
CC       regulation of cilium length (By similarity). Acts as a positive
CC       regulator of hedgehog (Hh)signaling (By similarity). May participate in
CC       the trafficking and/or retention of GLI2 and GLI3 proteins at the
CC       ciliary tip (By similarity). {ECO:0000250|UniProtKB:E7F187,
CC       ECO:0000250|UniProtKB:Q7Z3E5, ECO:0000250|UniProtKB:Q9D2I5}.
CC   -!- SUBUNIT: Interacts with TOGARAM1, CCDC66, CEP104, CSPP1 and CEP290.
CC       {ECO:0000250|UniProtKB:Q7Z3E5}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250|UniProtKB:Q7Z3E5}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q9D2I5}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome, centriole
CC       {ECO:0000250|UniProtKB:Q7Z3E5}. Note=Localized to the proximal region
CC       in cilia. Stimulation of Hh signaling leads to redistribution of ARMC9
CC       toward the ciliary tip within 6 hours, follow by a gradual return to
CC       its original proximal location (By similarity). Localizes to the
CC       daughter centriole of the primary cilium in RPE1 cells (By similarity).
CC       {ECO:0000250|UniProtKB:Q7Z3E5, ECO:0000250|UniProtKB:Q9D2I5}.
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DR   EMBL; CR860670; CAH92787.1; -; mRNA.
DR   RefSeq; NP_001126627.1; NM_001133155.1.
DR   AlphaFoldDB; Q5R629; -.
DR   SMR; Q5R629; -.
DR   STRING; 9601.ENSPPYP00000014826; -.
DR   GeneID; 100173624; -.
DR   KEGG; pon:100173624; -.
DR   CTD; 80210; -.
DR   eggNOG; ENOG502QQ9W; Eukaryota.
DR   InParanoid; Q5R629; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0097542; C:ciliary tip; ISS:UniProtKB.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0045880; P:positive regulation of smoothened signaling pathway; ISS:UniProtKB.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR040369; ARMC9.
DR   InterPro; IPR006594; LisH.
DR   PANTHER; PTHR14881; PTHR14881; 1.
DR   SMART; SM00667; LisH; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50896; LISH; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium biogenesis/degradation; Coiled coil; Cytoplasm;
KW   Cytoskeleton; Phosphoprotein; Reference proteome.
FT   CHAIN           1..665
FT                   /note="LisH domain-containing protein ARMC9"
FT                   /id="PRO_0000280597"
FT   DOMAIN          7..39
FT                   /note="LisH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT   REGION          642..665
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          201..235
FT                   /evidence="ECO:0000255"
FT   MOD_RES         582
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z3E5"
SQ   SEQUENCE   665 AA;  75834 MW;  2F0229997B23E8C3 CRC64;
     MGDILAHESE LLGLVKEYLD FAEFEDTLKT FSKECKIKGK PLCKTVGGSF RDSKSLTIQK
     DLVTAFDNGD QKVFFNLWEE HIPSSVRDGD SFAQRLEFYL HIHFAIYLLK YSVGRPDKEE
     LDEKISYFKT YLETKGAALS QTTEFLPFYA LPFVPNPMVH PSFKELFQDS WTPELKMKLE
     KFLALIFKAS NTPKLLTIYK ENGQSNKEML QQLHQQLVEA ERRSMTYLKR YNKIQADYHN
     LIGVTAELVD SLEATVSGKM ITPEYLQSVC VRLFSNQMRQ SLAHSVDFTR PGTASTMLRA
     SLAPVKLKDV PLLPSLDYEK LKKDLILGSD RLKAFLLQAL RWRLTTSHPG EQRETVLQAY
     ISNDLLDCYS HNQRSVLQLL HSKSDVVRQY MARLINAFAS LAEGRLYLAQ NTKVLRMLEG
     RLKEEDKDII TRENVLGALQ KFSLRRPLQT AMIQDGLIFW LVDVLKDPDC LSDYTLEYSV
     ALLMNLCLRS TGKNMCAKVA GLVLKVLSDL LGHENHEIQP YVSGALYSIL SVPSIREEAR
     AMGMEDILRC FIKEGNAEMI RQIEFIIKQL NSEELPDGVL ESDDDEDEDD EEDHDIMEAD
     LDKDELIQPQ LGELSGEKLL TTEYLGIMTN TGKMRRKGLA NVQWSGDEPL QRPVTPGGHR
     NGYPV