ID   ARMC9_RAT               Reviewed;         730 AA.
AC   A1A5P5;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=LisH domain-containing protein ARMC9;
GN   Name=Armc9;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Involved in ciliogenesis. It is required for appropriate
CC       acetylation and polyglutamylation of ciliary microtubules, and
CC       regulation of cilium length (By similarity). Acts as a positive
CC       regulator of hedgehog (Hh)signaling (By similarity). May participate in
CC       the trafficking and/or retention of GLI2 and GLI3 proteins at the
CC       ciliary tip (By similarity). {ECO:0000250|UniProtKB:E7F187,
CC       ECO:0000250|UniProtKB:Q7Z3E5, ECO:0000250|UniProtKB:Q9D2I5}.
CC   -!- SUBUNIT: Interacts with TOGARAM1, CCDC66, CEP104, CSPP1 and CEP290.
CC       {ECO:0000250|UniProtKB:Q7Z3E5}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250|UniProtKB:Q7Z3E5}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q9D2I5}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome, centriole
CC       {ECO:0000250|UniProtKB:Q7Z3E5}. Note=Localized to the proximal region
CC       in cilia. Stimulation of Hh signaling leads to redistribution of ARMC9
CC       toward the ciliary tip within 6 hours, follow by a gradual return to
CC       its original proximal location (By similarity). Localizes to the
CC       daughter centriole of the primary cilium in RPE1 cells (By similarity).
CC       {ECO:0000250|UniProtKB:Q7Z3E5, ECO:0000250|UniProtKB:Q9D2I5}.
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DR   EMBL; BC128749; AAI28750.1; -; mRNA.
DR   AlphaFoldDB; A1A5P5; -.
DR   SMR; A1A5P5; -.
DR   STRING; 10116.ENSRNOP00000059344; -.
DR   PaxDb; A1A5P5; -.
DR   PRIDE; A1A5P5; -.
DR   UCSC; RGD:1305615; rat.
DR   RGD; 1305615; Armc9.
DR   eggNOG; ENOG502QQ9W; Eukaryota.
DR   InParanoid; A1A5P5; -.
DR   PhylomeDB; A1A5P5; -.
DR   PRO; PR:A1A5P5; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0097542; C:ciliary tip; ISS:UniProtKB.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0045880; P:positive regulation of smoothened signaling pathway; ISS:UniProtKB.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR040369; ARMC9.
DR   InterPro; IPR006594; LisH.
DR   PANTHER; PTHR14881; PTHR14881; 1.
DR   SMART; SM00667; LisH; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50896; LISH; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium biogenesis/degradation; Coiled coil; Cytoplasm;
KW   Cytoskeleton; Phosphoprotein; Reference proteome.
FT   CHAIN           1..730
FT                   /note="LisH domain-containing protein ARMC9"
FT                   /id="PRO_0000280598"
FT   DOMAIN          7..39
FT                   /note="LisH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT   REGION          675..730
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          205..242
FT                   /evidence="ECO:0000255"
FT   MOD_RES         583
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z3E5"
SQ   SEQUENCE   730 AA;  82337 MW;  33701F3EF3F021B1 CRC64;
     MGDVLAHESE LLGLVKEYLD FAEFEDTLKT FSKECKVKGK PLCKTVGGSL KKDSNSLMIQ
     KDLVAAFDSG DQKLFFDLWE GHIPSSIRDT DSLAQKLEFY LHIHFAIYLL KYSGGRPDRQ
     ELDERISYFK TYLETKGASL SQTTEFLPFY ALPFVPNPMV HPSFKELFQD SWTPELKLKL
     EKFLALIFKA SNTPKLLTIY KENGSNNKEM LQQLHQQLLE AERRAMAYLK RYNKMQADYH
     SLIGVTAELV DSLEATVSGK MITPEYLQSV CVRLFSNQMR QSLAHSVDFT RPGTASTMLR
     ASLAPEKLKD VPLLPSLDYE KLKKDLIWGS DRLKAFLLQA LRWRLTTSHP GEQRETVLQA
     YISNDLLDCH SHNQRSVLQL LHSKSEAVRQ YMARLVNALA SLAEGRLYLA QNTKVLRMLE
     GRLKEEDKDV ITRENVLGAL QKFSLRRPLQ TAMIRDGLIF WLIDLLKEPD CLSDYTLEYS
     VALLMNLCLR SAGKNMCAKV AGLMLKVLSD LLGHENHEIQ PYVNGALYSI LSIPSIREEA
     RAMGMEDILR CFIKEGNAEM IRQIEFIIKQ LNSEDLLDGV LESDDDEDED DEEDHDIMEA
     DLDKDELIQP QLGELSGEKL LTTEYLGIMT NTGKARRKGL ASVQWSGDEP LRRPVTPGGH
     RTGCPVVGDH LISSQNAQQA RNGCPRPIPV AQPDDYKEGK RGVAGRATPS SCKSAECAEP
     VLSSGAQKPK