ID   ARMC9_XENLA             Reviewed;         806 AA.
AC   Q5U245;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=LisH domain-containing protein ARMC9;
GN   Name=armc9;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in ciliogenesis. It is required for appropriate
CC       acetylation and polyglutamylation of ciliary microtubules, and
CC       regulation of cilium length (By similarity). Acts as a positive
CC       regulator of hedgehog (Hh)signaling (By similarity).
CC       {ECO:0000250|UniProtKB:E7F187, ECO:0000250|UniProtKB:Q7Z3E5,
CC       ECO:0000250|UniProtKB:Q9D2I5}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250|UniProtKB:Q7Z3E5}. Cell projection, cilium
CC       {ECO:0000250|UniProtKB:Q9D2I5}. Cytoplasm, cytoskeleton, microtubule
CC       organizing center, centrosome, centriole
CC       {ECO:0000250|UniProtKB:Q7Z3E5}. Note=Localized to the proximal region
CC       in cilia. Stimulation of Hh signaling leads to redistribution of ARMC9
CC       toward the ciliary tip within 6 hours, follow by a gradual return to
CC       its original proximal location (By similarity). Localizes to the
CC       daughter centriole of the primary cilium in RPE1 cells (By similarity).
CC       {ECO:0000250|UniProtKB:Q7Z3E5, ECO:0000250|UniProtKB:Q9D2I5}.
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DR   EMBL; BC086285; AAH86285.1; -; mRNA.
DR   RefSeq; NP_001088639.1; NM_001095170.1.
DR   AlphaFoldDB; Q5U245; -.
DR   SMR; Q5U245; -.
DR   PRIDE; Q5U245; -.
DR   GeneID; 495691; -.
DR   KEGG; xla:495691; -.
DR   CTD; 495691; -.
DR   Xenbase; XB-GENE-990027; armc9.L.
DR   OrthoDB; 1327587at2759; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 495691; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0097542; C:ciliary tip; ISS:UniProtKB.
DR   GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0045880; P:positive regulation of smoothened signaling pathway; ISS:UniProtKB.
DR   Gene3D; 1.25.10.10; -; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR040369; ARMC9.
DR   InterPro; IPR006594; LisH.
DR   PANTHER; PTHR14881; PTHR14881; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS50896; LISH; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium biogenesis/degradation; Coiled coil; Cytoplasm;
KW   Cytoskeleton; Reference proteome.
FT   CHAIN           1..806
FT                   /note="LisH domain-containing protein ARMC9"
FT                   /id="PRO_0000280599"
FT   DOMAIN          7..39
FT                   /note="LisH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT   REGION          576..604
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          650..736
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          748..806
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          194..230
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        577..601
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        651..728
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   806 AA;  91493 MW;  7D187975C7AE78B7 CRC64;
     MGDILAYEAD LLGLVKEFLN FGEFQETLEC FSKECKIKGK LLPRTSGSSL RESKTLLIQK
     DLITAFEDGD IKEFFALWQE HIPVETQNTN PVAQKLEFYL QIHFAIFPLK QSQGRIDRVD
     CEERISHFKT YLETSGAALS QTTEFLPFYA LPFVPNPAAH PSFKEIFQES WEAELKMRLE
     KFLSVILKAA STPKLITLYK ESLHNNQEQL QQLQQQLMET EHKARTYKKC FNKMQSDYHN
     LIGVTADLVD SLEATINGKL ITPEYLQSVC TRLFSAQMKQ SSAQSIDFTR PGTASSMLRA
     SIAPLKQQEV PLFPSLDYEK LKKDLVFGND RLKAFILQAL RWRLTRSQPG EQRNTVLQAY
     ISNDLLDCQH NEQKNVLILL RSPSEVVRQY TALLIDVCAS LGYGRVYLSQ NPRLLHSLVE
     AWKAEEKESI ARETVLGILQ KLSLRRSMQS AMIKDDLIFW LVRELEDPDH LSDYALQYTI
     ALFMNLCLRT AGRKLCSRDA DHVLKVLSDL LGHENHEIRS YVNGALYSIL AVPSIREEAR
     SMGMEEILRW YIREGNPDMN CHIEFIIRQL NSEDKFDESV ESDDEEEEKD DEEDEDALEA
     DLDKDEIIHA QSGELSGEKL LTTDYLGIMT NSFKVKKRMF AGILQSADEP LQRPVTPSSH
     RAMNTVRKNS NSPSPLTNTF KSSQANKMSL SSSRPPTRSG SRASSSDSID SEASRLFSPN
     SLTDHRGAMS PTSPRILDLG MEKNIVQNSS KAWLPRSPEV QNATSRKTRT PTIAPQFSQS
     GPQQTSYSSS AGSSTRSRQS TQSYRK