ARMD3_MOUSE
ID ARMD3_MOUSE Reviewed; 689 AA.
AC Q6PD19; Q3TWB1; Q80V50;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Armadillo-like helical domain-containing protein 3 {ECO:0000250|UniProtKB:Q5T2E6};
GN Name=Armh3 {ECO:0000250|UniProtKB:Q5T2E6};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 217-689 (ISOFORM 1).
RC STRAIN=C57BL/6J, and FVB/N;
RC TISSUE=Brain, Mammary tumor, and Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Involved in GBF1 recruitment, Golgi maintenance and protein
CC secretion. {ECO:0000250|UniProtKB:Q5T2E6}.
CC -!- SUBUNIT: Interacts with PI4KB. Interacts with GBF1.
CC {ECO:0000250|UniProtKB:Q5T2E6}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000250|UniProtKB:Q5T2E6}; Single-pass type I membrane protein
CC {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q5T2E6}. Note=The
CC majority of ARMD3 is cytosolic, with a portion colocalizing with GBF1
CC at juxtanuclear Golgi sites. {ECO:0000250|UniProtKB:Q5T2E6}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q6PD19-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6PD19-2; Sequence=VSP_035671;
CC Name=3;
CC IsoId=Q6PD19-3; Sequence=VSP_035672, VSP_035673;
CC -!- SIMILARITY: Belongs to the ARMH3 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH46389.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
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DR EMBL; AK159765; BAE35355.1; -; mRNA.
DR EMBL; AC131185; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC150685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC046389; AAH46389.1; ALT_SEQ; mRNA.
DR EMBL; BC048392; AAH48392.1; -; mRNA.
DR EMBL; BC058989; AAH58989.1; -; mRNA.
DR CCDS; CCDS50454.1; -. [Q6PD19-1]
DR RefSeq; NP_938038.2; NM_198296.2. [Q6PD19-1]
DR RefSeq; XP_011245647.1; XM_011247345.2. [Q6PD19-1]
DR AlphaFoldDB; Q6PD19; -.
DR BioGRID; 214816; 2.
DR STRING; 10090.ENSMUSP00000048454; -.
DR iPTMnet; Q6PD19; -.
DR PhosphoSitePlus; Q6PD19; -.
DR SwissPalm; Q6PD19; -.
DR EPD; Q6PD19; -.
DR MaxQB; Q6PD19; -.
DR PaxDb; Q6PD19; -.
DR PeptideAtlas; Q6PD19; -.
DR PRIDE; Q6PD19; -.
DR Antibodypedia; 64513; 13 antibodies from 7 providers.
DR DNASU; 71617; -.
DR Ensembl; ENSMUST00000045396; ENSMUSP00000048454; ENSMUSG00000039901. [Q6PD19-1]
DR GeneID; 71617; -.
DR KEGG; mmu:71617; -.
DR UCSC; uc008hrv.1; mouse. [Q6PD19-1]
DR UCSC; uc008hrw.1; mouse. [Q6PD19-3]
DR CTD; 79591; -.
DR MGI; MGI:1918867; Armh3.
DR VEuPathDB; HostDB:ENSMUSG00000039901; -.
DR eggNOG; KOG4654; Eukaryota.
DR GeneTree; ENSGT00390000002554; -.
DR HOGENOM; CLU_029861_2_0_1; -.
DR InParanoid; Q6PD19; -.
DR OMA; GFWTEFF; -.
DR OrthoDB; 1024171at2759; -.
DR PhylomeDB; Q6PD19; -.
DR TreeFam; TF300220; -.
DR BioGRID-ORCS; 71617; 12 hits in 75 CRISPR screens.
DR PRO; PR:Q6PD19; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q6PD19; protein.
DR Bgee; ENSMUSG00000039901; Expressed in interventricular septum and 133 other tissues.
DR Genevisible; Q6PD19; MM.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0000139; C:Golgi membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:1903358; P:regulation of Golgi organization; ISS:UniProtKB.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039868; ARMD3-like.
DR InterPro; IPR013636; ARMH3_C.
DR PANTHER; PTHR13608; PTHR13608; 1.
DR Pfam; PF08427; DUF1741; 1.
DR SMART; SM01158; DUF1741; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Golgi apparatus; Membrane;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..689
FT /note="Armadillo-like helical domain-containing protein 3"
FT /id="PRO_0000284516"
FT TRANSMEM 520..538
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..424
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_035671"
FT VAR_SEQ 499..514
FT /note="ALINLLKFLMSNETVL -> GIILKLSGSAASTYTF (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_035672"
FT VAR_SEQ 515..689
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_035673"
SQ SEQUENCE 689 AA; 78632 MW; B7D19DBA66A99312 CRC64;
MAQVEKRGGL LRKSSASKKP LKEKVVLMYD EIFMTEDPSK CSPRFWEELF LMKVNLEYLE
GKLESLDGEE LMKIKDNINC LFQHCIQALG EEHPIRVVNA LQTLCALIRG VHQKNKSTSG
FDIINMLMGF DKAELCMKNL MESLDSLLCA EGSESLKSLC LKLLLCLVTV TDNISQNTIL
EYVMINSIFE AILQILSHPP SRREHGYDAV VLLALLVNYR KYESVNPYIV KLSIVDDEAT
LNGMGLVITQ ALSEYNRQYK DKEEEHQSGF FSALTNMVGS MFIADAHEKL SVQTNEAILL
ALYEAVHLNR NFITVLAQSH PEMGLVTAPA SPTPTTPATP LGTTPPSSDV ISSVELSLDA
DVQTSNLLIT FLKYSSIVMQ DTKDEHRLHS GKLCLIILTC IAEDQYANAF LHDDNMNFRV
NLHRMPMRHR KKAADKNLPC RPLVCAVLDL MVEFIVTHMM KEFPMDLYLR CVQVVHKLLC
YQKKCRVRLH YTWRELWSAL INLLKFLMSN ETVLLAKHNI FTLALMIVNL FNMFITYGDT
FLPTPSSYDE LYYEIIRMHQ SFDNLYSMVL RLSTNAGQWK EAASKVTHAL VNIRAIINHF
NPKIESYAAV NHISQLSEEQ VLEVVRANYD TLTLKLQDGL DQYERYSEQH KEAAFFKELV
RSISTNVRRN LAFHTLSQEA LLKEFSTIS
