ID   ARMD3_XENLA             Reviewed;         689 AA.
AC   Q6DCT2; Q5HZ90;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-NOV-2008, sequence version 2.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Armadillo-like helical domain-containing protein 3 {ECO:0000250|UniProtKB:Q5T2E6};
GN   Name=armh3 {ECO:0000250|UniProtKB:Q5T2E6};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Egg, and Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in Golgi maintenance and protein secretion.
CC       {ECO:0000250|UniProtKB:Q5T2E6}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q5T2E6}; Single-pass membrane protein
CC       {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q5T2E6}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6DCT2-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6DCT2-2; Sequence=VSP_024555;
CC   -!- SIMILARITY: Belongs to the ARMH3 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH77914.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC077914; AAH77914.1; ALT_INIT; mRNA.
DR   EMBL; BC089132; AAH89132.1; -; mRNA.
DR   RefSeq; NP_001087026.2; NM_001093557.1. [Q6DCT2-1]
DR   AlphaFoldDB; Q6DCT2; -.
DR   MaxQB; Q6DCT2; -.
DR   PRIDE; Q6DCT2; -.
DR   DNASU; 446861; -.
DR   GeneID; 446861; -.
DR   KEGG; xla:446861; -.
DR   CTD; 446861; -.
DR   Xenbase; XB-GENE-5897006; armh3.L.
DR   OMA; GFWTEFF; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 446861; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0000139; C:Golgi membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:1903358; P:regulation of Golgi organization; ISS:UniProtKB.
DR   InterPro; IPR039868; ARMD3-like.
DR   InterPro; IPR013636; ARMH3_C.
DR   PANTHER; PTHR13608; PTHR13608; 1.
DR   Pfam; PF08427; DUF1741; 1.
DR   SMART; SM01158; DUF1741; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cytoplasm; Golgi apparatus; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..689
FT                   /note="Armadillo-like helical domain-containing protein 3"
FT                   /id="PRO_0000284518"
FT   TRANSMEM        520..538
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         1..415
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_024555"
SQ   SEQUENCE   689 AA;  79036 MW;  53E7A203EE0E4946 CRC64;
     MAQIEKKVGL LRKSSASKKP LKEKVVLMYD EIFTKEDPTK SNPRFWDELF LMKVNIEYLE
     SKLESLDGEE LMKLKDNINS LFQHCIHALR AEHQIRVVNS LQTLCALIRG VHQKNKPTSG
     FDIINMLMGF DKAELRMKNL MESLDLLLCG DGSESLKSLC LKLLLCLVTV TDNISQNTIL
     EYVMINSIFE AILQILSNPL SRRQHGYDAV VLLALLVNYR KYESVNPYIV KLSIVDDENT
     LNGMGLVIAR ALFEYNRQYT DKEEENQTGF FSALTNMVGS MFIADADEKI SVQTNEAILL
     ALYEAVHLNR NFITVLAQSH PEMGLVAVPI SPIPTTPTSP LGTTPPSSDV ISPTELPMDA
     DVQTSNLLIT FLKYSSIVMQ DTKDEHRLNS GKLCLIILTC IAEDQYANAF LHDDNMNFRV
     NLHRMPMRHR KKAADKNIPC RPLVCAVLDL MVEFIVTHMM KDFPMDLYTR CIQIVHKVLC
     YQKKCRVRLH YTWRELWLAL INLLKFLMSN ETVLLAKHNI FTLTLMVVNL FNMFITYGDT
     FLPTPSSYDE LYYEIIRMHQ IFDNLYSMVL RLSTNAGQWK EPASKVTHSL VNIRAIINHF
     NPKIESYAAV NHISQLSEEQ VLEVVRSNYD TLTLKLQDGL DQYERYSEQH KEAAFFKELA
     RSISINVRKN VAFNTLSQEI LLKEFSTIS